Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 452
Aptamer sequence: ACGCUCAACGAGCCAGGAACAUCGACGUCAGCAAACGCGAGCGCAACCAGUAACACC
Target unique ID: Q14242
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_447 PF377 Protein SELPL_HUMAN N/A Washed with PBS and 0.9 mM CaCl2, 0.5 mM MgCl2, 2.67 mM KCl, 1.47 mM KH2PO4, 135 mM NaCl 21793788
Structure information of aptamer
Aptamer Sequence: ACGCUCAACGAGCCAGGAACAUCGACGUCAGCAAACGCGAGCGCAACCAGUAACACC
The optimal secondary structure in dot-bracket notation: .(((((..(((..........)))......((....)))))))..............
The centroid secondary structure in dot-bracket notation: .(((((................................)))))..............
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_447 Description PF377
Aptamer chemistry RNA Length 57 nt
GC content 57.9% Molecular weight 18,338.12 Da
Molarity of 1 μg/μl solution 54.53 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Targeted therapy
Sequence ACGCUCAACGAGCCAGGAACAUCGACGUCAGCAAACGCGAGCGCAACCAGUAACACC
Applications Potential utility of aptamers to block endothelial adhesion molecules to prevent or treat vaso-occlusion in SCD
Target information
Type Detail Type Detail
Uniprot ID Q14242 Protein name P-selectin glycoprotein ligand 1 (PSGL-1) (Selectin P ligand) (CD antigen CD162)
Gene name(s) SELPLG Organism P-selectin glycoprotein ligand 1 (PSGL-1) (Selectin P ligand) (CD antigen CD162)
Status reviewed in uniprot database Length 412
Mass 43,201 Activity regulation N/A
Involvement in disease N/A Catalytic activity N/A
PDB ID(s)
1G1S;
Function A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation.
Activity data

No relevant experimental diagram

 Interaction ID 452
Target type Protein
Target unique ID Q14242
Activity N/A
Binding Conditions/Buffer

Washed with PBS and 0.9 mM CaCl2, 0.5 mM MgCl2, 2.67 mM KCl, 1.47 mM KH2PO4, 135 mM NaCl
Assay

N/A
PubMed ID 21793788
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_269 RNA AACGCUCAACGUCAGAAGGCAACGUAUAGGCAAGCACACUUCGACAUGAGGC 56.14%
Apta_496 RNA GGGCUAGCUGAUCGUACCCAGUAGCGUGGCAUGGGGUGCCUAGUCGGGCGAUACUAACAGCUAACACCC 55.07%
Apta_453 RNA GGGCUAGCUGAUCGUACCAGUAGCGUGGCCUGGGGGGCCUAGUCGUGCGAUACUAACAGCUAACACCC 54.41%
Apta_612 RNA GGGCGACCCUGAUGAGCCUUAGGAUAUGCUUCGGCAGAAGGACGUCGAAACGGUGAAAGCCGUAGGUUGCCC 54.17%
Apta_1113 DNA CCGCCCAAATCCCTAAGAGCACAAACACCAAACACAACCACCCCAACCAGACACACTACACACGCA 53.03%
Apta_574 RNA AUGAAAAGGGCUGGCGAGACAUAUCCGCUGGGCAAUCAGAUUCGGAGCCGCACCACCCUCGAAGUAGACA 52.86%
Apta_153 RNA CCACAGUUCAGAGGCACCGCGAACAAAACGCAAGACAGAGUGCCGACAAGAAC 52.63%
Apta_292 RNA CUACGAACUCAUGACACAAGGAUGCAAUCUCAUCCCGCCAGCCCACCGU 52.63%
Apta_366 RNA GGUUAGAGGCGACGUCCCGGAAUCCGCGCCCAUUGCCCCC 52.63%
Apta_1122 RNA ACAACCCGGAACAACGUCUAACAGUGUACCAUAACCCGGCAUUCA 52.63%
Apta_1166 RNA GAUGUAACUGAAUGAAAUGGUGAAGGACGGGUCCAGUAGGCUGC 52.63%
Apta_316 DNA CCGCCCAAATCCCTAAGAGAAGACTGTAATGACATCAAACCAGACACACTACACACGCA 52.54%
Apta_599 RNA GUCUCUGUGUGCGCCAGAGAACACUGGGGCAGAUAUGGGCCAGCACAGAAUGAGGCCC 51.72%
Apta_599 RNA GUCUCUGUGUGCGCCAGAGAACACUGGGGCAGAUAUGGGCCAGCACAGAAUGAGGCCC 51.72%
Apta_1232 DNA GGCCACACAAACAACATGACAACACGTCTCACATAACGCCCACGTGCTGCCGCCTCATCG 51.67%
Apta_766 RNA GGUUACCAGCCUUCACUGCGGACGGACAGAGAGUGCAACCUGCCGUGCCGCACCACGGUCGGUCACAC 51.47%
Apta_296 RNA AUACCAGCUUAUUCAAUUGCCUGAAAACCUGGUCUCUCUGUCAGCAAAGACUAUGTUGAGAUAGUAAGUGCAAUCU 51.32%
Apta_3 DNA CCTGCCTTTGGCAGCCGGGCGAAGGCAACCCGACACCGACAGC 50.88%
Apta_4 DNA CCTGCCTTTGGAACCGACCGCCAGGCCGAGGAAAGGCACCGACAGC 50.88%
Apta_142 DNA CGCACATCAGTTTAGCAGCGCCAAAGGCGGAAGCGCA 50.88%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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