AptaDB: Result

Interaction ID: 142

Aptamer sequence: GCCUGUAAGGUGGUCGGUGUGGCGAGUGUGUUAGGAGAGAUUGC

Target unique ID: P02741

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_402	cy3-RNA	Protein	CRP_HUMAN	125 nM	HEPES at pH 6.5 with 0.005% Tween 20	18066708

Aptamer Sequence:	GCCUGUAAGGUGGUCGGUGUGGCGAGUGUGUUAGGAGAGAUUGC
The optimal secondary structure in dot-bracket notation:	.((((....(((.(((......))).)))..)))).........
The centroid secondary structure in dot-bracket notation:	.(((.......(.(((......))).).....))).........

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_402	Description	cy3-RNA
Aptamer chemistry	RNA	Length	44 nt
GC content	56.8%	Molecular weight	14,346.49 Da
Molarity of 1 μg/μl solution	69.70 μM	Number of G-quadruplexes	2
G-Score	19	Function	Aptasensor
Sequence	GCCUGUAAGGUGGUCGGUGUGGCGAGUGUGUUAGGAGAGAUUGC
Applications	Aptasensor for C-reactive protein

Type	Detail	Type	Detail
Uniprot ID	P02741	Protein name	C-reactive protein [Cleaved into: C-reactive protein(1-205)]
Gene name(s)	CRP PTX1	Organism	C-reactive protein [Cleaved into: C-reactive protein(1-205)]
Status	reviewed in uniprot database	Length	224
Mass	25,039	Activity regulation	N/A
Involvement in disease	N/A	Catalytic activity	N/A
PDB ID(s)	1B09;1GNH;1LJ7;3L2Y;3PVN;3PVO;7PK9;7PKB;7PKD;7PKE;7PKF;7PKG;7PKH;
Function	Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine.

No relevant experimental diagram	Interaction ID	142
	Target type	Protein
	Target unique ID	P02741
	Activity	125 nM
	Binding Conditions/Buffer	HEPES at pH 6.5 with 0.005% Tween 20
	Assay	N/A
	PubMed ID	18066708

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_51	RNA	GCCUUAGUAACGUGCUUUGAUGUCGAUUCGACAGGAGGC	56.82%
Apta_241	RNA	GCUUGACGGAGAUCAAGGGCGAGUCUCAUACCAAGUUGAUGGGG	54.55%
Apta_243	RNA	GCUUGAAGCUAGCAGUAAGACUAGCGCUACGGAUGGGUGUGCG	54.55%
Apta_606	RNA	CGGUUGGAUGGGUGUUGGUGGUUUGUUGAGUCCAGGCGGC	54.55%
Apta_634	RNA	GGUCUUACGUCGUUCGCGACUAUUGGGAGACC	54.55%
Apta_703	RNA	GGGCGGAUGAGACGCUUGGCGUGUGCUGUGGAGAGUCAUCCG	54.55%
Apta_925	RNA	GCUCGGCCAGGUCGCGGGUGGAUGUGAGGG	54.55%
Apta_98	RNA	CGAUGCGGUCUCAUGCGUCGAGUGUGAGUUUACCUUCG	52.27%
Apta_230	RNA	GGGAGGACGAUGCGGGCGUGAAUGGUGUUGUGAGG	52.27%
Apta_632	RNA	GACGAGAAGGAGUGCUGGUUAUACUAGCGGUUAGGUCACUCGUC	52.27%
Apta_1168	RNA	GCGACUACGGUGAGGGUCGGGUCCAGUAGCUUCGGCUACUGUUGAGUAGAGUGUGGGCUCCGUAGUCGC	52.17%
Apta_599	RNA	GUCUCUGUGUGCGCCAGAGAACACUGGGGCAGAUAUGGGCCAGCACAGAAUGAGGCCC	51.72%
Apta_599	RNA	GUCUCUGUGUGCGCCAGAGAACACUGGGGCAGAUAUGGGCCAGCACAGAAUGAGGCCC	51.72%
Apta_81	RNA	GCAAUGGUACGGUACUUCCAAGUGCGGGGGGGAGGUGGUGGUUCCAAAAGUGCACGCUACUUUGCUAA	51.47%
Apta_718	RNA	GGGUUGUGAGCUCCCGGCUCGCAUUGUGAGGUGGAGGGGGACGUGCUGCAGGUCGACGCAUGCGCCG	50.75%
Apta_96	RNA	UCGCUAAUUAUAGGCGGAGUGCGACGUUAUAAAUA	50.00%
Apta_218	RNA	AGCCGCGAGGGGAGGGAUAGGGUAGGGCGCGGCU	50.00%
Apta_594	RNA	GGGCUAUUGCUGGAGGGGCGCCACAUGAAAGUGGUGGUUGGGUGCGGUCGGCGAUAGCUC	50.00%
Apta_633	RNA	GGCAUCGGAAAGUGGGUUGAUGUAAGUAACAGGCGAUGCC	50.00%
Apta_713	RNA	GGCGGUGCUGGCCGAAAGGCGCUUGGAAACGUC	50.00%

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