Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 599
Aptamer sequence: GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGCCCUGCGAUGCAGAAAGGUGCUGACGACACAUCGAAACGGUAGCGAGAGCUC
Target unique ID: 135445730
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_566 AR2 Molecule Cyclic gmp N/A 50 mM Tris-HCl, pH 7.5, 20 mM MgCl2 11283591
Structure information of aptamer
Aptamer Sequence: GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGCCCUGCGAUGCAGAAAGGUGCUGACGACACAUCGAAACGGUAGCGAGAGCUC
The optimal secondary structure in dot-bracket notation: ........(((((.((((((....)))))).(((((((((((...........))).))).......)))))..)))))(((....))).
The centroid secondary structure in dot-bracket notation: ........(((((.((((((....))))))......((((((...........))).)))..............)))))(((....))).
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_566 Description AR2
Aptamer chemistry RNA Length 90 nt
GC content 55.6% Molecular weight 29,203.48 Da
Molarity of 1 μg/μl solution 34.24 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Aptasensor
Sequence GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGCCCUGCGAUGCAGAAAGGUGCUGACGACACAUCGAAACGGUAGCGAGAGCUC
Applications Recognition of cAMP
Target information
Type Detail Type Detail
PubChem ID 135445730 Molecular name Cyclic gmp
Molecular formula C10H11N5NaO7P Molecular weight 367.19
IUPAC name sodium;9-[(4aR,6R,7R,7aS)-7-hydroxy-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-1H-purin-6-one InChIKey KMPIYXNEROUNOG-GWTDSMLYSA-M
LogP -5.152 Topological polar surface area 177.64
Hydrogen bond acceptor 11 Hydrogen bond donor 3

Synonym(s):
40732-48-7; Monosodium-GMP; Guanosine 3',5'-cyclic monophosphate sodium salt; cyclic gmp; UNII-6WYT1TNR45; Sodium guanosine cyclic monophosphate; Guanosine Monophosphate Monosodium Salt; Cyclic gmp sodium salt; 6WYT1TNR45; GUANOSINE3:5-CYCLICMONOPHOSPHATESODIUMSALT; MFCD00038424; sodium;9-[(4aR,6R,7R,7aS)-7-hydroxy-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-amino-3H-purin-6-one; Guanosine-3':5'-cyclic monophosphate monosodium salt; cGMP sodium salt; EINECS 255-056-0; Cyclic 3',5'-Guanosine Monophosphate Monosodium Salt; 3',5'-cGMP-Na; C10H11N5O7P.Na; DTXSID30860018; Guanosine, cyclic 3',5'-(hydrogen phosphate), monosodium salt; 3',5'-Cyclic GMP monosodium salt; 7032AH; AKOS037646872; AS-71285; Guanosine 3',5'-cyclophosphate monosodium salt; Guanosine 3:5-cyclic monophosphate sodium salt; guanosine 3',5'-cyclic-monophosphate sodium salt; GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD; Q27265640; Guanosine 3',5'-cyclic monophosphate sodium salt, >=99.0% (HPLC); Guanosine 3',5'-cyclic monophosphate sodium salt, >=99% (HPLC), powder; Guanosine 3',5'-cyclic Monophosphate, Sodium Salt - CAS 40732-48-7; sodium (4aR,6R,7R,7aS)-6-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-7-hydroxy-2-oxo-hexahydro-2??-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate

Activity data

No relevant experimental diagram

 Interaction ID 599
Target type Molecule
Target unique ID 135445730
Activity N/A
Binding Conditions/Buffer

50 mM Tris-HCl, pH 7.5, 20 mM MgCl2
Assay

N/A
PubMed ID 11283591
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_562 RNA GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGCCUUUAGGGCCAAGUGUGGUGAAAGACACACUCGAAACGGUAGCGAGAGCUC
85.56%
Apta_561 RNA GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGCCUGUGGAAACAGACGUGGCACAUGACUACGUCGAAACGGUAGCGAGAGCUC
84.44%
Apta_613 RNA GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGCCUUAGGAUAUGCAUGAUGCAGAAGGACGUCGAAACGGUAGCGAGAGCUC
84.44%
Apta_710 RNA GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGUCUGGAUACCAUGCAUGAUGCACCUUGGCAGUCUUACGAAACGGUAGCGAGAGCUC 79.79%
Apta_563 RNA GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGAAAGCCAAAGCCGUAGCGCAGAUGAUCUCGCCAUCAGUACCGAAACGGUAGCGAGAGCUC 77.55%
Apta_874 RNA GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGCCUUAGGAUAUGUCUGGAUACCAUGCAUGAUGCACCUUGGCAGUCUUACAGAAGGACGUCGAAACGGUAGCGAGAGCUC 71.79%
Apta_551 RNA GGAUGUCCAGUCGCUUGCAAUGCCCUUUUAGACCCUGAUGAGCGGUGCUAGUUAGUUGCAGUUUCGGUUGUUACGCGAAACGGUGAAAGCCGUAGGUCU 56.57%
Apta_305 RNA GGGAGGACGAUGCGGAUCGCCCUGAACCGGCCCAGCAGACUGCUGACGGCACGAUCCGCAUCGUCCUCCC 55.56%
Apta_559 RNA GGAUGUCCAGUCGCUUGCAAUGCCCUUUUAGACCCUGAUGAGGAUCAUCGGACUUUGUCCUGUGGAGUAAGAUCGCGAAACGGUGAAAGCCGUAGGUCU 55.56%
Apta_38 RNA GGUAGAUACGAUGGAUACCCCCUGUGGCCCGUCAACACAGGGGAAGUGGCAUGACGCGCAGCCA 54.44%
Apta_766 RNA GGUUACCAGCCUUCACUGCGGACGGACAGAGAGUGCAACCUGCCGUGCCGCACCACGGUCGGUCACAC 54.44%
Apta_301 RNA AUACCAGCUUAUUCAAUUGCCUGAAAAGUUGAACUCCAAAUACGCGCUGAGAUAGUAAGUGCAAUCU 53.33%
Apta_416 RNA GGACCUCGGCGAAAGCCGGUAACGCCACAAGUCGGAGGGUAAGAUCUGACAGGAACUGGGUGACGGAGGUUAGGUGC 53.33%
Apta_612 RNA GGGCGACCCUGAUGAGCCUUAGGAUAUGCUUCGGCAGAAGGACGUCGAAACGGUGAAAGCCGUAGGUUGCCC 53.33%
Apta_280 RNA GAUAAUACGACUCACUAUAGGGUUCACUGCAGACUUGACGAAGCUUGCAGAAAAGGGGGAAGAAGAGGGUGAUUCAGGCGAGAGAAUGGAUCCACAUCUACGAAUUC 53.27%
Apta_39 RNA GGUAGAUACGAUGGACUACCGCCACCCCGGGUCCGGGUGACGUUAAUUGAGGGCCCAUGACGCGCAGCCA 52.22%
Apta_314 RNA GGUUACCAGCCUUCACUGCUCCCGGACGCGUCUGUAUCCGCUACCCGCCGCACCACGGUCGGUCACAC 52.22%
Apta_522 RNA GGGCGACCCUGAUGAGCACACGAGGGGGAAACCCCGGACAAUCAGACACGGUGUUCGAAACGGUGAAAGCCGUAGGUUGCCCUUU 52.22%
Apta_574 RNA AUGAAAAGGGCUGGCGAGACAUAUCCGCUGGGCAAUCAGAUUCGGAGCCGCACCACCCUCGAAGUAGACA 52.22%
Apta_599 RNA GUCUCUGUGUGCGCCAGAGAACACUGGGGCAGAUAUGGGCCAGCACAGAAUGAGGCCC 52.22%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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