AptaDB: Result

Interaction ID: 447

Aptamer sequence: TGAATCTCGCGCTCGTTGGTACCCTTAAAATAAAGGCATA

Target unique ID: Q13651

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_441	454	Protein	I10R1_HUMAN	8 nM	100 mM NaCl Selection Buffer (20 mM, HEPES, 2 mM CaCl2, 0.1 mg/mL BSA)	26007661

Aptamer Sequence:	TGAATCTCGCGCTCGTTGGTACCCTTAAAATAAAGGCATA
The optimal secondary structure in dot-bracket notation:	......................((((......))))....
The centroid secondary structure in dot-bracket notation:	......................((((......))))....

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_441	Description	454
Aptamer chemistry	DNA	Length	40 nt
GC content	42.5%	Molecular weight	12,278.93 Da
Molarity of 1 μg/μl solution	81.44 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted binding
Sequence	TGAATCTCGCGCTCGTTGGTACCCTTAAAATAAAGGCATA
Applications	Bind human receptors and cross-react with their murine orthologs

Type	Detail	Type	Detail
Uniprot ID	Q13651	Protein name	Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)
Gene name(s)	IL10RA IL10R	Organism	Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)
Status	reviewed in uniprot database	Length	578
Mass	63,003	Activity regulation	N/A
Involvement in disease	Inflammatory bowel disease 28, autosomal recessive (IBD28)	Catalytic activity	N/A
PDB ID(s)	1J7V;1LQS;1Y6K;1Y6M;1Y6N;5IXI;6X93;
Function	Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.

No relevant experimental diagram	Interaction ID	447
	Target type	Protein
	Target unique ID	Q13651
	Activity	8 nM
	Binding Conditions/Buffer	100 mM NaCl Selection Buffer (20 mM, HEPES, 2 mM CaCl2, 0.1 mg/mL BSA)
	Assay	N/A
	PubMed ID	26007661

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_510	DNA	TGTAATTTGTCTGCAGCGGTTCTTGATCGCTGACACCATATTATGAAGA	55.10%
Apta_845	DNA	CCAAACGCGCTGGTTTGGAATGCTTAGAGTTTGATCGATGCCTAA	53.33%
Apta_846	DNA	GTGCAGACAGCTAGTAGTGGTGACTTTCTGTCCAAATCAAGATAA	53.33%
Apta_930	DNA	TTGCACTATGTTTTAGCTAGGGTTCCCTCCGGAGATAGTAAGTGCAA	53.19%
Apta_597	DNA	TACTGGGCTGGGCTTGGATTAGATCACAGTGGAACATACAGGACACACG	53.06%
Apta_273	DNA	ATAAGCTGAGCATCTTAGATCCCCGTCAAGGGCAGCGTAA	52.50%
Apta_973	DNA	TATGTAATGTTGACGTAATTTATCTCTGTGAGAATAAGCAGGTGGTATCC	52.00%
Apta_969	DNA	TAACCACCCCACCTCGCTCCCGTGACACTAATGCTAATTCCAA	51.16%
Apta_642	DNA	ATCCAATACCTCAGAACTCAGTTCGAGTCGTAAAGGGGAATCGCA	51.11%
Apta_49	DNA	CTTCCATGTTGAGGCGTTTATACCAGTTATCATCGGACTA	50.00%
Apta_144	DNA	GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCGATAGAGGTAG	50.00%
Apta_183	DNA	TAGCACTGTGCGGCGCGTATTGTTCTAATCTGATTACATT	50.00%
Apta_285	DNA	GCCACTCCGTCACTTTAGTGGTTTTTTTTATAAATGCTTC	50.00%
Apta_436	DNA	CCCCCGCATCACGCCGTGGTGCGATTGACACAATTGCAAT	50.00%
Apta_440	DNA	AAAGACCGTTTTTTAAAACGCTCAATATACACGACATAAA	50.00%
Apta_473	DNA	CCCTGCACTCGCAATGGCCCCTCTACACCACAAACGGACA	50.00%
Apta_1191	DNA	TAATACTACCAACTTCTTTGCCTGGCGTAAGTAACAGTCA	50.00%
Apta_1272	DNA	TCCGTGTATAGGTCGGGTCTCTTGCCAACTGATTCGTTGAAAAGTATAGCCCCGCAGGG	49.15%
Apta_143	DNA	GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCGATAGAGGTAGTTTCG	48.98%
Apta_644	DNA	TCAATCTAACCATGCATGCAGTTTAGGCAGGATTCGTTATCGCAA	48.89%

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