AptaDB: Result

Interaction ID: 242

Aptamer sequence: UUCAACGCUGUGAAGGGCUUAUACGAGCGGAUUACCC

Target unique ID: P06756

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_237	Clone 17.16	Protein	ITAV_HUMAN	N/A	PBS and 0.9 mM CaCl2, 0.5 mM MgCl2, 2.67 mM KCl, 1.47 mM KH2PO4, 135 mM NaCl	21793788

Aptamer Sequence:	UUCAACGCUGUGAAGGGCUUAUACGAGCGGAUUACCC
The optimal secondary structure in dot-bracket notation:	.........((((...((((....))))...))))..
The centroid secondary structure in dot-bracket notation:	.....(((..................)))........

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_237	Description	Clone 17.16
Aptamer chemistry	RNA	Length	37 nt
GC content	51.4%	Molecular weight	12,095.01 Da
Molarity of 1 μg/μl solution	82.68 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted therapy
Sequence	UUCAACGCUGUGAAGGGCUUAUACGAGCGGAUUACCC
Applications	Block endothelial adhesion molecules to prevent or treat vaso-occlusion in SCD

Type	Detail	Type	Detail
Uniprot ID	P06756	Protein name	Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]
Gene name(s)	ITGAV MSK8 VNRA VTNR	Organism	Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]
Status	reviewed in uniprot database	Length	1048
Mass	116,038	Activity regulation	N/A
Involvement in disease	N/A	Catalytic activity	N/A
PDB ID(s)	1JV2;1L5G;1M1X;1U8C;3IJE;4G1E;4G1M;4MMX;4MMY;4MMZ;4O02;4UM8;4UM9;5FFG;5FFO;5NEM;5NER;5NET;5NEU;6AVQ;6AVR;6AVU;6DJP;6MK0;6MSL;6MSU;6NAJ;6OM1;6OM2;6UJA;6UJB;6UJC;
Function	The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF.

No relevant experimental diagram	Interaction ID	242
	Target type	Protein
	Target unique ID	P06756
	Activity	N/A
	Binding Conditions/Buffer	PBS and 0.9 mM CaCl2, 0.5 mM MgCl2, 2.67 mM KCl, 1.47 mM KH2PO4, 135 mM NaCl
	Assay	N/A
	PubMed ID	21793788

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_93	RNA	CUCCGCUAUCUAACGUAUGAUAGAAUGGAUGACUA	56.76%
Apta_632	RNA	GACGAGAAGGAGUGCUGGUUAUACUAGCGGUUAGGUCACUCGUC	54.55%
Apta_268	RNA	CUUAUAGGGGAGGCUGUGGUGAGGGAAUAUUAAGAGAAUUAACGGUCUAGUUCACCUCGA	51.67%
Apta_377	RNA	CUUCGGGAUUUGAGGGUAGAAUGGGACUA	51.35%
Apta_378	RNA	UGCUCUUAGAAUGGGACUAAGACACGGGAC	51.35%
Apta_1121	RNA	GACAGCGUGCCUAGAAGUCCAAGCUUAAAUAACCACGCUCGACAAGC	51.06%
Apta_241	RNA	GCUUGACGGAGAUCAAGGGCGAGUCUCAUACCAAGUUGAUGGGG	50.00%
Apta_269	RNA	AACGCUCAACGUCAGAAGGCAACGUAUAGGCAAGCACACUUCGACAUGAGGC	50.00%
Apta_367	RNA	CGAGCGUAGAAUGUCUUCCCACUAGACGUCGUUCGGCCCC	50.00%
Apta_271	RNA	CUGUCGAGCAUGCUCAGGGUAACGUAUAGUCAAGACACCUCAAGUGUAACU	49.02%
Apta_1142	RNA	ACGAGUCACACGUUGAUGACUGGAUGGUAGUUAAAGAGGGUGGGGCAACAA	49.02%
Apta_292	RNA	CUACGAACUCAUGACACAAGGAUGCAAUCUCAUCCCGCCAGCCCACCGU	48.98%
Apta_668	RNA	GGAACCCAACUAGGCGUUUGAGGGGAUUCGGCCACGGUAACAACCCCUC	48.98%
Apta_381	RNA	AUUCUGUUGGCGAACUGUACGCAAGUACUGGAUGACAGCCUAUCUAU	48.94%
Apta_92	RNA	ACAACUUAAUGCGACGUUGGUAAAGCAUAUCAAAC	48.65%
Apta_152	RNA	UUACCACGCGCUCUUAACUGCUAGCGCCAUGGC	48.65%
Apta_212	RNA	AGGAAGGCUUUAGGUCUGAGAUCUCGGAAU	48.65%
Apta_379	RNA	UACGACACGAUUGGGACGUGUCUAUGGGAC	48.65%
Apta_855	RNA	UCACUGUUAUCCGAUAGCAGCGCGGGAUGA	48.65%
Apta_1167	RNA	GGCGCGAGGAAGGAGGUCUGAGGAGGUCACUGCGCC	48.65%

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