Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 243
Aptamer sequence: CACACATTCCCGTCCTCGATACGTCTAGGCTTAGTGCCACTTGCTTAATC
Target unique ID: P06756
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_238 | αV-1 | Protein | ITAV_HUMAN | 2.7 nM | PBS supplemented with 0.05% Tween-20 and 0.1% BSA | 22624874 |
Structure information of aptamer
| Aptamer Sequence: | CACACATTCCCGTCCTCGATACGTCTAGGCTTAGTGCCACTTGCTTAATC |
| The optimal secondary structure in dot-bracket notation: | ...........................(((.....)))............ |
| The centroid secondary structure in dot-bracket notation: | ...........................(((.....)))............ |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_238 | Description | αV-1 |
| Aptamer chemistry | DNA | Length | 50 nt |
| GC content | 50.0% | Molecular weight | 15,422.68 Da |
| Molarity of 1 μg/μl solution | 64.84 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Target recognition |
| Sequence | CACACATTCCCGTCCTCGATACGTCTAGGCTTAGTGCCACTTGCTTAATC | ||
| Applications | Recognize the αV and β3 subunits | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Uniprot ID | P06756 | Protein name | Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain] |
| Gene name(s) | ITGAV MSK8 VNRA VTNR | Organism | Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain] |
| Status | reviewed in uniprot database | Length | 1048 |
| Mass | 116,038 | Activity regulation | N/A |
| Involvement in disease | N/A | Catalytic activity | N/A |
| PDB ID(s) | 1JV2;1L5G;1M1X;1U8C;3IJE;4G1E;4G1M;4MMX;4MMY;4MMZ;4O02;4UM8;4UM9;5FFG;5FFO;5NEM;5NER;5NET;5NEU;6AVQ;6AVR;6AVU;6DJP;6MK0;6MSL;6MSU;6NAJ;6OM1;6OM2;6UJA;6UJB;6UJC; |
 |
Function | The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. |
Activity data
 |
Interaction ID | 243 |
| Target type | Protein | |
| Target unique ID | P06756 | |
| Activity | 2.7 nM | |
| Binding Conditions/Buffer | PBS supplemented with 0.05% Tween-20 and 0.1% BSA |
|
| Assay | Affiinity measurement of aptamers αV-1 and β3-1 |
|
| PubMed ID | 22624874 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_444 | DNA | AGCCATTACGATGTCGTTACGTAGATGCAGAGACTCCTAA | |
| Apta_913 | DNA | GGCACTTGTTTGCTCGAACGATGGTTTGTGCTTTTGTGTT | |
| Apta_1278 | DNA | CCATGATTCAACTTTACTGGTCTTGTCTTGGCTAGTCGTGTGTCATTCCCTAAGG | |
| Apta_357 | DNA | ACAATGTCGCTCTCCGCCGCAGGAGCATTGTCTGTCTTTATGCTTCTCTTTTTTGTTGC | |
| Apta_570 | DNA | GGCAAGATGTGCCCAGAACAGTTGCTTGTATGGTGGGGAGCGTCCATATTGGCTTAAAC | |
| Apta_438 | DNA | AGCCATGACGATGTCGTTACGTAGATGCAGAGACTCCTAA | |
| Apta_438 | DNA | AGCCATGACGATGTCGTTACGTAGATGCAGAGACTCCTAA | |
| Apta_443 | DNA | GGCCATGACGATGTCGTTACGTAGATGCAGAGACTCCTAA | |
| Apta_445 | DNA | AGCCATGACGATGTCGTTACGTAGATGTAGAGACTCCTAA | |
| Apta_446 | DNA | AGCCATGACGATGTCGTTACGTAGATGCATAGACTCCTAA | |
| Apta_821 | DNA | CACAGTCACTCAGACGGCCGCTATTGTTGCCAGATTGCCTTTGGC | |
| Apta_969 | DNA | TAACCACCCCACCTCGCTCCCGTGACACTAATGCTAATTCCAA | |
| Apta_654 | DNA | GCACACCGATGGCGGTCCTGTTTTACGGTAGCTTATATGCAGGGGGTGTGCGTG | |
| Apta_614 | DNA | AATCGCATTACCTTATACCAGCTTATTCAATTACGTCTGCACATACCAGCTTATTCAATT | |
| Apta_1000 | DNA | ATAGGAGTCGACCGACCAGAACCGTTCCCATACTTCTCCAGCGATACTTAGTGCGTCTACATCTAGACTC | |
| Apta_7 | DNA | CCAGTCTCCCGTTTACCGCGCCTACACATGTCTGAATGCC | |
| Apta_58 | DNA | GCACCTTGATGACATGATAGTCGTTGTGTATGCAGTTGGC | |
| Apta_182 | DNA | AAAAAAGCCCCCCCTTCGACCGTATACCAGGGTACGGAATG | |
| Apta_348 | DNA | ACTTGCTCTGATGCGACAACCTTTTGCCCAGATAGTAAGT | |
| Apta_387 | DNA | CTTTAATGCCCTTCACTAGGTCTAAGCTACTACTTACCCG |
DEV TOOL
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