AptaDB: Result

Interaction ID: 1183

Aptamer sequence: TCGGGCGAGTCGTCTGCGAGGCAACAAGCTCGTAATCCGCATCGTCCTCCC

Target unique ID: PCS-100-042

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_1127	Aptamer NSC	Cell	Vascular Smooth Muscle Cell Growth Kit	N/A	100 nmol/l NaCl, 10 mmol/l Tris HCl pH 8.0, 0.5% SDS	26732878

Aptamer Sequence:	TCGGGCGAGTCGTCTGCGAGGCAACAAGCTCGTAATCCGCATCGTCCTCCC
The optimal secondary structure in dot-bracket notation:	..((((((..((..((((((........))))))...))..))))))....
The centroid secondary structure in dot-bracket notation:	..((((((..((..((((((........))))))...))..))))))....

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_1127	Description	Aptamer NSC
Aptamer chemistry	DNA	Length	51 nt
GC content	62.7%	Molecular weight	15,612.99 Da
Molarity of 1 μg/μl solution	64.05 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted therapy
Sequence	TCGGGCGAGTCGTCTGCGAGGCAACAAGCTCGTAATCCGCATCGTCCTCCC
Applications	Inhibition of vascular smooth muscle cell (VSMC) proliferation

Type	Detail	Type	Detail
ATCC ID	PCS-100-042	Cell name	Vascular Smooth Muscle Cell Growth Kit
Category	Reagents	Organism	N/A
Product type	N/A	Cell type	N/A
Morphology	N/A	Tissue	N/A
Disease	N/A	Product format	Frozen
Antigen expression	N/A	Genes expressed	N/A
Cell description	Vascular Smooth Muscle Cell Growth Kit contains components that when added to Vascular Cell Basal Medium create a complete ATCC Primary Cell Solution culture environment for smooth muscle cells derived from large vessels.
Application(s)	Cell growth and viability

	Interaction ID	1183
	Target type	Cell
	Target unique ID	PCS-100-042
	Activity	N/A
	Binding Conditions/Buffer	100 nmol/l NaCl, 10 mmol/l Tris HCl pH 8.0, 0.5% SDS
	Assay	Binding of selected RNA aptamers to vascular smooth muscle cells in culture
	PubMed ID	26732878

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_1126	DNA	TCGGGCGAGTCGTCTGCGGGCGGATAGACTACGACACCGCATCGTCCTCCC	80.39%
Apta_1125	DNA	TCGGGCGAGTCGTCTGGGGAGGTCAGAACGAAAGGCCCGCATCGTCCTCCC	76.47%
Apta_509	DNA	TCGCGCGAGTCGTCTGGGGGACTAGAGGACTTGTGCGGCCCCGCATCGTCCTCCC	72.73%
Apta_335	DNA	ACCGGGCGTACACCGTCGCGGCACATGTCTGAATGCGTTTAGTCTCTGTG	56.86%
Apta_697	DNA	CTCTCGGGACGACGGACGCTAATCTTACAAGGGCGTAGTGTATGTCGTCCC	56.86%
Apta_788	DNA	TACCAGTGCGATGCTCAGTAACTTTGAAGGAAAGGCTACAAACTCTTCCTGACGCATTCGGTTGAC	56.06%
Apta_369	DNA	GGCTGTTGTGAGCCTCCTCCCAGAGGGAAGACTTTAGGTTCGGTTCACGTCCCGCTTATTCTTACTCCC	55.07%
Apta_160	DNA	CGGTGCAGTGGATACATGCCAGCCGTAGCCATCGTGGATA	54.90%
Apta_486	DNA	GGGAGGGATTGGGTGGGCACAGCTCGCTGATAGGTCCTGGTCTCAC	54.90%
Apta_733	DNA	TAGGCAGTGGTTTGACGTCCGCATGTTGGGAATAGCCACGCCT	54.90%
Apta_847	DNA	CACTAGGATCTAGGGAAAAATCTCGTAAATACTATACTCCTGAGC	54.90%
Apta_877	DNA	GTGCGAAGCGCCTCCACTGTACATCCACTCCTTCTGCC	54.90%
Apta_980	DNA	AACGAGCACGCTTTGTGTACAGCCACTAAATAAGGTATGTAGTCAGCACCCTCGTAAC	53.45%
Apta_981	DNA	TATGGAGAGTCAATGAGTACAGTCTCGTCTCAATAACGGAGCCTCGTCCGTGCCCCCG	53.45%
Apta_32	DNA	CGGTAAACTGCGTCCGAAGGGGCTGCAGTGACCCGAATGGGTCCG	52.94%
Apta_393	DNA	AGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCT	52.94%
Apta_439	DNA	TAACACTCGATTCTCCTAGCCCGCTAGAAATTCCCCTCCC	52.94%
Apta_487	DNA	CGGGGAGTTGGGAGGGGGGGCAAAGCCTGTGTATTTATCTTCTGT	52.94%
Apta_585	DNA	GATCGAGGGCAGCGATAGCTGGGCTAATAAGGTTAGCCCCATCGGTC	52.94%
Apta_635	DNA	TAGCCGGATCGCGCTGGCCAGATGATATAAAGGGTCAACCCCCCA	52.94%

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