Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 1180
Aptamer sequence: GGGCGAAUUCGGGUUGGAUAGUAGGCGCAUAUGGCAUCUUCGUGGUUGUGUAUUGCCCUUUAGUGAGGGUUAAUU
Target unique ID: P04637
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_1124 2′-O-methyl modified RNA aptamer Protein P53_HUMAN N/A 0.15 mM Hepes [pH 7.4], 0.3 mM KCl, 6 μM dithiothreitol [DTT], 6 μM MgCl2, 1.1 μM ethylenediaminetetraacetic acid 23816877
Structure information of aptamer
Aptamer Sequence: GGGCGAAUUCGGGUUGGAUAGUAGGCGCAUAUGGCAUCUUCGUGGUUGUGUAUUGCCCUUUAGUGAGGGUUAAUU
The optimal secondary structure in dot-bracket notation: ..((..((((.....)))).))..(((((.((.((......)).)))))))...((((((....)))))).....
The centroid secondary structure in dot-bracket notation: ......((((.....)))).....(((((.((.((......)).)))))))...((((((....)))))).....
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_1124 Description 2′-O-methyl modified RNA aptamer
Aptamer chemistry RNA Length 75 nt
GC content 48.0% Molecular weight 24,205.19 Da
Molarity of 1 μg/μl solution 41.31 μM Number of G-quadruplexes 2
G-Score 19 Function Target detection
Sequence GGGCGAAUUCGGGUUGGAUAGUAGGCGCAUAUGGCAUCUUCGUGGUUGUGUAUUGCCCUUUAGUGAGGGUUAAUU
Applications Detection of p53
Target information
Type Detail Type Detail
Uniprot ID P04637 Protein name Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene name(s) TP53 P53 Organism Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Status reviewed in uniprot database Length 393
Mass 43,653 Activity regulation N/A
Involvement in disease TP53 is found in increased amounts in a wide variety of transformed cells Catalytic activity N/A
PDB ID(s)
1A1U;1AIE;1C26;1DT7;1GZH;1H26;1HS5;1JSP;1KZY;1MA3;1OLG;1OLH;1PES;1PET;1SAE;1SAF;1SAK;1SAL;1TSR;1TUP;1UOL;1XQH;1YC5;1YCQ;1YCR;1YCS;2AC0;2ADY;2AHI;2ATA;2B3G;2BIM;2BIN;2BIO;2BIP;2BIQ;2F1X;2FEJ;2FOJ;2FOO;2GS0;2H1L;2H2D;2H2F;2H4F;2H4H;2H4J;2H59;2J0Z;2J10;2J11;2J1W;2J1X;2J1Y;2J1Z;2J20;2J21;2K8F;2L14;2LY4;2MEJ;2MWO;2MWP;2MWY;2MZD;2OCJ;2PCX;2RUK;2VUK;2WGX;2X0U;2X0V;2X0W;2XWR;2YBG;2YDR;2Z5S;2Z5T;3D05;3D06;3D07;3D08;3D09;3D0A;3DAB;3DAC;3IGK;3IGL;3KMD;3KZ8;3LW1;3OQ5;3PDH;3Q01;3Q05;3Q06;3SAK;3TG5;3TS8;3ZME;4AGL;4AGM;4AGN;4AGO;4AGP;4AGQ;4BUZ;4BV2;4HFZ;4HJE;4IBQ;4IBS;4IBT;4IBU;4IBV;4IBW;4IBY;4IBZ;4IJT;4KVP;4LO9;4LOE;4LOF;4MZI;4MZR;4QO1;4RP6;4RP7;4X34;4XR8;4ZZJ;5A7B;5AB9;5ABA;5AOI;5AOJ;5AOK;5AOL;5AOM;5BUA;5ECG;5G4M;5G4N;5G4O;5HOU;5HP0;5HPD;5LAP;5LGY;5MCT;5MCU;5MCV;5MCW;5MF7;5MG7;5MHC;5MOC;5O1A;5O1B;5O1C;5O1D;5O1E;5O1F;5O1G;5O1H;5O1I;5OL0;5UN8;5XZC;6FF9;6FJ5;6GGA;6GGB;6GGC;6GGD;6GGE;6GGF;6LHD;6R5L;6RJZ;6RK8;6RKI;6RKK;6RKM;6RL3;6RL4;6RL6;6RM5;6RM7;6RWH;6RWI;6RWS;6RWU;6RX2;6RZ3;6S39;6S3C;6S40;6S9Q;6SHZ;6SI0;6SI1;6SI2;6SI3;6SI4;6SIN;6SIO;6SIP;6SIQ;6SL6;6SLV;6T58;6V4F;6V4H;6VQO;6VR1;6VR5;6VRM;6VRN;6W51;6XRE;6ZNC;7B46;7B47;7B48;7B49;7B4A;7B4B;7B4C;7B4D;7B4E;7B4F;7B4G;7B4H;7B4N;7BWN;7DHY;7DHZ;7DVD;7EAX;7EL4;7NMI;7RM4;
Function Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type.
Activity data

No relevant experimental diagram

 Interaction ID 1180
Target type Protein
Target unique ID P04637
Activity N/A
Binding Conditions/Buffer

0.15 mM Hepes [pH 7.4], 0.3 mM KCl, 6 μM dithiothreitol [DTT], 6 μM MgCl2, 1.1 μM ethylenediaminetetraacetic acid
Assay

N/A
PubMed ID 23816877
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_719 RNA GGAAUGGAUCCACAUCUACGAAGGCUUUGAAGGUGAGACCGUGCAAAUGAGGAUGGUGUGGAUGAUUAGGGUUGUCGGUUUUCACUGCAGACUUGACGAAGCUU 53.85%
Apta_594 RNA GGGCUAUUGCUGGAGGGGCGCCACAUGAAAGUGGUGGUUGGGUGCGGUCGGCGAUAGCUC 53.33%
Apta_720 RNA GGGAGAAUUCCGACCAGAAGCUUAGUAUAGCGAGGUUUAGCUACACUCGUGCUGAUCGUUUGGUACGGGACCUGCGUGUAGCCCAUAUGUGCGUCUACAUGGAUCCUCA 53.21%
Apta_413 RNA GUGAGACCAGCCGAGUGGUGUCUGGCUAUUCACUGGAGCGUGGGUGGAACCCCUGCGCACUCGUUUGGCUGUCCGGGCCUUCGGGCCGGGAUUAUCUCU 52.53%
Apta_893 RNA ACCGAGUCCAGAAGCUUGUAGUACUUAUGUCCCAUCGAACGCAGUGUAUCUUGCACCGACUCUCUGCCUAGAUGGAGUUGAAUUCUCCCUAUAGUGAGUCGUAUUAC 51.40%
Apta_414 RNA GGGAGGACGAUGCGGCCGAUUAGAACUGGGCUGAGGCGUUCUGCAUUUCGGUGAUCAGACGACUCGCUGAGGAUCCGAGA 51.25%
Apta_816 RNA GGGUUCACUGCAGACUUGACGAAGCUUGAGAGAUGCCCCCUGAUGUGCAUUCUUGUUGUGUUGCGGCAAUGGAUCCACAUCUACGAAUUC 51.11%
Apta_2 RNA GGGCUUCUCUGGUUAGACCAGAUUUGAGCCUGGGAGCUCUCUGGCUAACUAGGGAACCC 50.67%
Apta_696 RNA GAGUGCGCCCAUUGAUAAGAGCGUAGGUUCAACGGAGUCGUAGUCGUUCUCAAGUUGACGGUGCAUUAGAGUCCU 50.67%
Apta_695 RNA AUUGGAUCGGUAGUAUAGGUGAGACACUUCAUGCCUUUGUUGCAGGCUGGGGUGAAGGCGCUACAUGGCGUCUGAAA 50.65%
Apta_1290 RNA GCGCGAGAAACGGUCACUAGAAUAGUGGGCCGUCAUGCUAACGCCUCUUUCGGUGUUGGGGAAUAUUGGCCAAUCGAGU 50.63%
Apta_895 RNA ACCGAGUCCAGAAGCUUGUAGUACUACCGCAACGUUGGCGUUCGGCGUUGGCCGCGUCAUCGCUAGCCUAGAUGGAGUUGAAUUCUCCCUAUAGUGAGUCGUAUUAC 50.47%
Apta_169 RNA GGGAGACAAGACUAGACGCUCAAUGUGGGCCACGCCCGAUUUUACGCUUUUACCCGCACGCGAUUGGUUUGUUUUCGACAUGAGACUCACAACAGUUCCCUUUAGUGAGGGUUAAUU 50.43%
Apta_500 RNA GGGAGAAAGGGAAGCUUGAGGUGCUAUGGAGUGGAGGAGUUGAAGGUGUCGGGGUUGGCAGAAGAAGGCGAGCGUACGGAUCCAUC 50.00%
Apta_710 RNA GGAUAAUAGCCGUAGGUUGCGAAAGCGACCCUGAUGAGUCUGGAUACCAUGCAUGAUGCACCUUGGCAGUCUUACGAAACGGUAGCGAGAGCUC 50.00%
Apta_909 RNA GGGAAUUCGAGCUCGGUACCUUUACCGUAAGGCCUGUCUUCGUUUGACAGCGGCUUGUUGACCCUCCACUUUGUACCUGCUGCCAACUGCAGGCAUGCAAGCUUGG 50.00%
Apta_1223 RNA GGAGGCGCCAACUGAAUGAAAGGUUACGCUUCAACGCCGUGCAGCUGCUUCGGCAGGCUUGUGAGUACAUGGCCCAUUGAUCCGUAACUAGUCGCGUCAC 50.00%
Apta_410 RNA GGGAGAGCGGAAGCGUGCUGGGCCUGUCGUUCGCUGUGUCUUGCUACGUUACGUUACACGGUUGGCAUAACCCAGAGGUCGAUGG 49.41%
Apta_224 RNA GGGGCCACCAACGACAUUGAACCACGUAGGCUCGUUUCUGAGCCGAUCUCGAUGUUGAUAUAAAUAGUGCCCAUGGAUC 49.37%
Apta_548 RNA GGGAGAAGGCGGCGCGUAGGCGAGCUUUACCAGUUUUAUUUGUUUUAUUGUUAUAUGCUUAUUCGUGGACGAUGCGCAC 49.37%

ABOUT

AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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