Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 719
Aptamer sequence: TCGACCTCGCGCGAGGAGGGTGGAGGGTCGTAGAGCGCGTA
Target unique ID: 46783781
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_666 C2 Molecule Flavophospholipol 350 nM 20 mM HEPES (pH 7.4), 150 mM NaCl, and 5 mM MgCl2 11557343
Structure information of aptamer
Aptamer Sequence: TCGACCTCGCGCGAGGAGGGTGGAGGGTCGTAGAGCGCGTA
The optimal secondary structure in dot-bracket notation: .((((((..(((.......)))..))))))...........
The centroid secondary structure in dot-bracket notation: .((((((..(((.......)))..))))))...........
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_666 Description C2
Aptamer chemistry DNA Length 41 nt
GC content 68.3% Molecular weight 12,813.19 Da
Molarity of 1 μg/μl solution 78.04 μM Number of G-quadruplexes 2
G-Score 20 Function Target recognition
Sequence TCGACCTCGCGCGAGGAGGGTGGAGGGTCGTAGAGCGCGTA
Applications Recognition of a disaccharide analogue of moenomycin
Target information
Type Detail Type Detail
PubChem ID 46783781 Molecular name Flavophospholipol
Molecular formula C69H107N4O35P Molecular weight 1583.6
IUPAC name (2S,3S,4R,5R,6R)-5-[(2S,3R,4R,5S,6R)-3-acetamido-5-[(2S,3R,4R,5S)-3-acetamido-4-hydroxy-6-methyl-5-[(2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-[(2-hydroxy-5-oxocyclopenten-1-yl)carbamoyl]oxan-2-yl]oxyoxan-2-yl]oxy-4-hydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-4-carbamoyloxy-6-[[(2R)-2-carboxy-2-[(2E,6E,13E)-3,8,8,14,18-pentamethyl-11-methylidenenonadeca-2,6,13,17-tetraenoxy]ethoxy]-hydroxyphosphoryl]oxy-3-hydroxy-3-methyloxane-2-carboxylic acid InChIKey PERZMHJGZKHNGU-XIGAONJHSA-N
LogP -1.428 Topological polar surface area 601.88
Hydrogen bond acceptor 32 Hydrogen bond donor 18

Synonym(s):
Flavomycin; 11015-37-5; Flavophospholipol; MFCD01742468; C69H107N4O35P; (2S,3S,4R,5R,6R)-5-(((2S,3R,4R,5S,6R)-3-Acetamido-5-(((2S,3R,4R,5S)-3-acetamido-4-hydroxy-6-methyl-5-(((2R,3R,4S,5R,6S)-3,4,5-trihydroxy-6-((2-hydroxy-5-oxocyc; AKOS016339637; KS-5173; I020; 015F375

Activity data
Interaction ID 719
Target type Molecule
Target unique ID 46783781
Activity 350 nM
Binding Conditions/Buffer

20 mM HEPES (pH 7.4), 150 mM NaCl, and 5 mM MgCl2
Assay

Effect of aptamers on the antibiotic activity of moenomycin A
PubMed ID 11557343
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_488 DNA CGACCAGGGTGGGAGGGGGACGGGCTGGCGGCGCGCGGTAATG 60.47%
Apta_47 DNA GACCTAGCAGTGGACATGTGGCAGGGTGAAGTGGCATCGTC 58.54%
Apta_831 DNA CCGCCCAGCGGGGGTAGGGCCGGACGTAGGAGGAGCTGCG 58.54%
Apta_745 DNA GGTTGCATGCCGTGGGGAGGGGGGTGGGTTTTATAGCGTACTCAG 57.78%
Apta_1035 DNA ATGCGGATCCCGCGCGGGTCTGAGGAGTGCGCGGTGCCAGTGAGTGCGCGAAGCTTGCGC 56.67%
Apta_46 DNA CGGGTGGGAGTTGTGGGGGGGGGTGGGAGGGTT 56.10%
Apta_63 DNA GACCCGTGGTAGGGTAGGATGGGGTGGTC 56.10%
Apta_218 RNA AGCCGCGAGGGGAGGGAUAGGGUAGGGCGCGGCU 56.10%
Apta_691 DNA CGACGCGCGTTGGTGGTGGATGGTGTGTTACACGTGTTGT 56.10%
Apta_255 DNA TAGCGATACTGCGTGGGTTGGGGCGGGTAGGGCCAGCAGTCTCGT 55.56%
Apta_819 DNA GCGCCCTCTCACGTGGCACTCAGAGTGCCGGAAGTTCTGCGTTAT 55.56%
Apta_1080 DNA CTTACGACCCAGGGGGGTGGACAGGCGGGGGTTAGGGGGGTCGTAAG 55.32%
Apta_1034 DNA ATGCGGATCCCGCGCGCGACCGTGTCAGCGGGGACTAGCGGTGTAGCGCGAAGCTTGCGC 55.00%
Apta_782 DNA AGGTGTGACTCGATCTGTGGGGGTTGGGGGGTGGTTTTTCGGAA 54.55%
Apta_1071 DNA TTGAAGTGACTCCGCACTGGGTGGGTGGGAGGGTCGTGCGGCTGGTCATAGCAGGGT 54.39%
Apta_618 DNA GCGGCAAATCAGCATACGAGTGTACAGGGACGGGACGGGTGGGTAAAAGGTGTCGCCTCAG 54.10%
Apta_940 DNA TGTGCGGGGGAGGGGAGTGGCGCTGTTGGTGCGGGTATAGCGCGTGGTGT 54.00%
Apta_1041 DNA TTGGCCCCGCGTGATCATTGAGGGGAGGAGCCGAGGCGGGTCCAAGATTG 54.00%
Apta_1043 DNA TTCAAGGCGGCGAGATTTAGTGGTTGGGAGGCTGTACGCCCTACGTGAAC 54.00%
Apta_1044 DNA TTTAACGTAACCTGCAAGGCGGGGAGGTGCGAGCCCCGTGTGTGGCTTGC 54.00%

ABOUT

AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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