Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 1290
Aptamer sequence: GGCCACCAAACCACACCGTCGCAACCGCGAGAACCGAAGTAGTGATCATGTCCCTGCGTG
Target unique ID: 5353447
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_1228 BT 10 Molecule Brevetoxin 2 92 nM 50 mM Tris, pH 7.5, and 10 mM MgCl2 25725463
Structure information of aptamer
Aptamer Sequence: GGCCACCAAACCACACCGTCGCAACCGCGAGAACCGAAGTAGTGATCATGTCCCTGCGTG
The optimal secondary structure in dot-bracket notation: ...(((((....(((..(((((.((..((.....))..)).)))))..)))...)).)))
The centroid secondary structure in dot-bracket notation: .................(((((.((..((.....))..)).)))))..............
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_1228 Description BT 10
Aptamer chemistry DNA Length 60 nt
GC content 60.0% Molecular weight 18,393.80 Da
Molarity of 1 μg/μl solution 54.37 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Aptasensor
Sequence GGCCACCAAACCACACCGTCGCAACCGCGAGAACCGAAGTAGTGATCATGTCCCTGCGTG
Applications Detection of BTX-2 in food samples
Target information
Type Detail Type Detail
PubChem ID 5353447 Molecular name Brevetoxin 2
Molecular formula C50H70O14 Molecular weight 895.1
IUPAC name 2-[[(21Z)-12-hydroxy-1,3,11,24,31,41,44-heptamethyl-39-oxo-2,6,10,15,19,25,29,34,38,43,47-undecaoxaundecacyclo[26.22.0.03,26.05,24.07,20.09,18.011,16.030,48.033,46.035,44.037,42]pentaconta-21,40-dien-14-yl]methyl]prop-2-enal InChIKey LYTCVQQGCSNFJU-KTKRTIGZSA-N
LogP 5.472 Topological polar surface area 155.9
Hydrogen bond acceptor 14 Hydrogen bond donor 1

Synonym(s):
Brevetoxin 2; brevetoxin pbtx-2; 79580-28-2; Brevetoxin T 34; 2-[[(21Z)-12-hydroxy-1,3,11,24,31,41,44-heptamethyl-39-oxo-2,6,10,15,19,25,29,34,38,43,47-undecaoxaundecacyclo[26.22.0.03,26.05,24.07,20.09,18.011,16.030,48.033,46.035,44.037,42]pentaconta-21,40-dien-14-yl]methyl]prop-2-enal; Brevetoxin PbTx 2; GB 2 toxin; T-34 toxin; GB 2 (Gymnodinium); Toxin T-34; T 4-7 toxin; Ptychodiscus brevis toxin 2; GB 2; T 4-7

Activity data

No relevant experimental diagram

 Interaction ID 1290
Target type Molecule
Target unique ID 5353447
Activity 92 nM
Binding Conditions/Buffer

50 mM Tris, pH 7.5, and 10 mM MgCl2
Assay

N/A
PubMed ID 25725463
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_686 DNA GGTCACCAACAACAGGGAGCGCTACGCGAAGGGTCAATGTGACGTCATGCGGATGTGTGG 60.00%
Apta_777 DNA GAGCCCTATCTCACACCGCACCCGCAAACTATCATCCTACATG 56.67%
Apta_335 DNA ACCGGGCGTACACCGTCGCGGCACATGTCTGAATGCGTTTAGTCTCTGTG 55.00%
Apta_688 DNA GCCATGACAACCAGAGGTACCCCCGCCCACCAGCCCCGAAGTCTGTCAGCCTAGTTGTTG 55.00%
Apta_730 DNA ACCAAACACAGATGCAACCTGACTTCTAACGTCATTTGGTG 55.00%
Apta_1227 DNA CACACCAAACACACAAGTGGACCCTGACGCATGGATAGGGTGACGGTATACGCGGGCATG 55.00%
Apta_1232 DNA GGCCACACAAACAACATGACAACACGTCTCACATAACGCCCACGTGCTGCCGCCTCATCG 55.00%
Apta_417 DNA GGCAGGAAGACAAACACCAGGTGAGGGAGACGACGCGAGTGTTAGATGGTAGCTGTTGGTCTGTGGTGCTGT 54.17%
Apta_425 RNA UGCCGCCAUAUCACACGGAUUUAAUCGCCGUAGAAAAGCAUGUCAAAGCCG 53.33%
Apta_663 DNA CACGCACAGAAGACACCTACAGGGCCAGATCACAATCGGTTAGTGAACTCGTACGGCGCG 53.33%
Apta_685 DNA GGGGCAACAAACACGGAAGAAAATGAATCTACATACGTGGACATATATCCTGCCGCGTG 53.33%
Apta_728 DNA CGACCCGGCACAAACCCAGAACCATATACACGATCATTAGTCTCCTGGGCCG 53.33%
Apta_875 DNA GCCGCGACCATACAACGCAAACAACACGCCTGTACGCTTG 53.33%
Apta_969 DNA TAACCACCCCACCTCGCTCCCGTGACACTAATGCTAATTCCAA 53.33%
Apta_1068 DNA CGGGACAAGACAACGAACGAACAGGAAGAGAACCGGAATGCAGACGTCAGGG 53.33%
Apta_1213 DNA GGACTTGAAGAAAAGGGCGACACGCGAAGTCGATGTCGCGTCTGCCTGAAGTCA 53.33%
Apta_1264 DNA CAACGATCGTACCACAGTACCCACCCACCAGCCCCAACATCATGCCCATGCGTCGGTGTG 53.33%
Apta_1265 DNA CACGCACACAACAGCCAATAATGTATAACGCTGTCCACTGTGTGGTGTCCCCCGCGTCG 53.33%
Apta_418 DNA TGGCAGGAAGACAAACACATCGTCGCGGCCTTAGGAGGGGCGGACGGGGGGGGGCGTGGTCTGTGGTGCTGT 52.78%
Apta_103 DNA AGCAGCACAGAGGTCAGATGCATCGCATTATTCGCGGCCGGCCAACGAGAGTATGTTTCTCCTATGCGTGCTACCGTGAA 52.50%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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