CNS Neuroscience & Therapeutics · 2026
Sequence evidence
RRRRRRRRRRRRRRRRRR
Section 2.1: R18D peptide, also known as ARG‐007 (H‐rrrrrrrrrrrrrrrrrr‐OH; lower case letters represent D‐arginine) was synthesized by Auspep.
Experimental observations
Table 1: R18D 325 nmol/kg reduced infarct volume by 47.2% (p=0.0003). Total infarct volume 149.4 ± 70.05 mm3 vs Vehicle Saline 283.09 ± 50.28 mm3.
Table 1: R18D 650 nmol/kg reduced infarct volume by 28.4% (p=0.008). Total infarct volume 202.6 ± 64.94 mm3 vs Vehicle Saline 283.09 ± 50.28 mm3.
Table 1: R18D 1100 nmol/kg reduced infarct volume by 27.9% (p=0.003). Total infarct volume 204.1 ± 48.26 mm3 vs Vehicle Saline 283.09 ± 50.28 mm3.
Table 1 and text: R18D 325 nmol/kg reduced hemisphere swelling by 5.6% (p=0.15). Hemisphere swelling 108.29 ± 10.53% vs Vehicle Saline 114.76 ± 7.36%.
Table 1 and text: R18D 650 nmol/kg reduced hemisphere swelling by 8.3% (p=0.01). Hemisphere swelling 105.26 ± 7.23% vs Vehicle Saline 114.76 ± 7.36%.
Table 1 and text: R18D 1100 nmol/kg reduced hemisphere swelling by 4.5% (p=0.14). Hemisphere swelling 109.56 ± 7.25% vs Vehicle Saline 114.76 ± 7.36%.
Table 2: R18D 325 nmol/kg group had 7.35% body weight loss from baseline (Day 0 to Day 1). Vehicle Saline group had 9.35% loss.
Table 2: R18D 650 nmol/kg group had 10.62% body weight loss from baseline (Day 0 to Day 1). Vehicle Saline group had 9.35% loss.
Table 2: R18D 1100 nmol/kg group had 9.97% body weight loss from baseline (Day 0 to Day 1). Vehicle Saline group had 9.35% loss.
Table 3: R18D 325 nmol/kg Cmax 5,328 ng/mL. Table footnote: Cmax observed 15 min after start of infusion for 325 nmol/kg dose.
Table 3: R18D 650 nmol/kg Cmax 11,977 ng/mL. Table footnote: Cmax observed 10 min after start of infusion for 650 and 1100 nmol/kg doses.
Table 3: R18D 1100 nmol/kg Cmax 17,313 ng/mL. Table footnote: Cmax observed 10 min after start of infusion for 650 and 1100 nmol/kg doses.
Table 3: R18D 325 nmol/kg T1/2 = 1.3 h / 78 min.
Table 3: R18D 650 nmol/kg T1/2 = 1.2 h / 72 min.
Table 3: R18D 1100 nmol/kg T1/2 = 1.2 h / 72 min.
Table 3: R18D 325 nmol/kg AUClast = 6,890 h*ng/mL.
Table 3: R18D 650 nmol/kg AUClast = 16,500 h*ng/mL.
Table 3: R18D 1100 nmol/kg AUClast = 26,200 h*ng/mL.
Table 3: R18D 325 nmol/kg AUCinf = 7,000 h*ng/mL.
Table 3: R18D 650 nmol/kg AUCinf = 16,700 h*ng/mL.
Table 3: R18D 1100 nmol/kg AUCinf = 26,400 h*ng/mL.
Table 3: R18D 325 nmol/kg CL = 2.19 mL/min/kg.
Table 3: R18D 650 nmol/kg CL = 1.83 mL/min/kg.
Table 3: R18D 1100 nmol/kg CL = 1.97 mL/min/kg.
Table 3: R18D 325 nmol/kg λz = 0.53 1/h.
Table 3: R18D 650 nmol/kg λz = 0.57 1/h.
Table 3: R18D 1100 nmol/kg λz = 0.58 1/h.
Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.
