ProForma 2.0
validated simple linear
RRRRRRRRRRRRRRRRRR
Back to Primary literature
Primary-literature peptidehigh evidence PepDiana evidence grade for a literature-derived identity; Medium indicates retained review flags, while High has no unresolved review flag.
PEPDIA-PLP-002564
R18D
Aliases: R18D
Normalized sequence
RRRRRRRRRRRRRRRRRR
18 amino acids
Release PepDiana-V1-20260620
27
Activity records
1
Source papers
27
Positive
0
Negative / threshold
Versioned scientific descriptors
Physicochemical properties and standard representations
Reported properties
No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.
Computed properties
physchem-20260620Molecular weight
2829.3579 Da
Molecular formula
C108H218N72O19
Theoretical pI
12
Net charge at pH 7
17.7599
GRAVY
-4.5
Instability index
550.4222
Aromaticity
0
Topological polar surface area
1672.22 Ų
cLogP
-22.6212
Hydrogen-bond donors
73
Hydrogen-bond acceptors
37
Rotatable bonds
107
Method: PepDiana sequence/structure descriptor pipeline
Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6
Calculated: 2026-06-20T11:01:38.358971+00:00
Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200
Sequence representations
HELM 2.0
validated simple linear
PEPTIDE1{R.R.R.R.R.R.R.R.R.R.R.R.R.R.R.R.R.R}$$$$V2.0
Canonical SMILES
validated
N=C(N)NCCCC(N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)O
Isomeric SMILES
validated
N=C(N)NCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)O
Paper-level observations
Experimental evidence grouped by activity
Other 18 records
PMC13239245
18 observationsOtherPositive observation
Record detail Table 3: R18D 325 nmol/kg Cmax 5,328 ng/mL. Table footnote: Cmax observed 15 min after start of infusion for 325 nmol/kg dose.
- Measure
- other
- Value
- 5,328 ng/mL
- Target
- Rattus norvegicus
- Assay
- Not reported by source
OtherPositive observation
Record detail Table 3: R18D 650 nmol/kg Cmax 11,977 ng/mL. Table footnote: Cmax observed 10 min after start of infusion for 650 and 1100 nmol/kg doses.
- Measure
- other
- Value
- 11,977 ng/mL
- Target
- Rattus norvegicus
- Assay
- Not reported by source
OtherPositive observation
Record detail Table 3: R18D 1100 nmol/kg Cmax 17,313 ng/mL. Table footnote: Cmax observed 10 min after start of infusion for 650 and 1100 nmol/kg doses.
- Measure
- other
- Value
- 17,313 ng/mL
- Target
- Rattus norvegicus
- Assay
- Not reported by source
OtherPositive observation
Record detail Table 3: R18D 325 nmol/kg T1/2 = 1.3 h / 78 min.
- Measure
- other
- Value
- 1.3 h / 78 min
- Target
- Rattus norvegicus
- Assay
- Not reported by source
OtherPositive observation
Record detail Table 3: R18D 650 nmol/kg T1/2 = 1.2 h / 72 min.
- Measure
- other
- Value
- 1.2 h / 72 min
- Target
- Rattus norvegicus
- Assay
- Not reported by source
OtherPositive observation
Record detail Table 3: R18D 1100 nmol/kg T1/2 = 1.2 h / 72 min.
- Measure
- other
- Value
- 1.2 h / 72 min
- Target
- Rattus norvegicus
- Assay
- Not reported by source
OtherPositive observation
Record detail Table 3: R18D 325 nmol/kg AUClast = 6,890 h*ng/mL.
- Measure
- other
- Value
- 6,890 h*ng/mL
- Target
- Rattus norvegicus
- Assay
- Not reported by source
OtherPositive observation
Record detail Table 3: R18D 650 nmol/kg AUClast = 16,500 h*ng/mL.
- Measure
- other
- Value
- 16,500 h*ng/mL
- Target
- Rattus norvegicus
- Assay
- Not reported by source
OtherPositive observation
Record detail Table 3: R18D 1100 nmol/kg AUClast = 26,200 h*ng/mL.
- Measure
- other
- Value
- 26,200 h*ng/mL
- Target
- Rattus norvegicus
- Assay
- Not reported by source
OtherPositive observation
Record detail Table 3: R18D 325 nmol/kg AUCinf = 7,000 h*ng/mL.
- Measure
- other
- Value
- 7,000 h*ng/mL
- Target
- Rattus norvegicus
- Assay
- Not reported by source
OtherPositive observation
Record detail Table 3: R18D 650 nmol/kg AUCinf = 16,700 h*ng/mL.
- Measure
- other
- Value
- 16,700 h*ng/mL
- Target
- Rattus norvegicus
- Assay
- Not reported by source
OtherPositive observation
Record detail Table 3: R18D 1100 nmol/kg AUCinf = 26,400 h*ng/mL.
- Measure
- other
- Value
- 26,400 h*ng/mL
- Target
- Rattus norvegicus
- Assay
- Not reported by source
OtherPositive observation
Record detail Table 3: R18D 325 nmol/kg CL = 2.19 mL/min/kg.
- Measure
- other
- Value
- 2.19 mL/min/kg
- Target
- Rattus norvegicus
- Assay
- Not reported by source
OtherPositive observation
Record detail Table 3: R18D 650 nmol/kg CL = 1.83 mL/min/kg.
- Measure
- other
- Value
- 1.83 mL/min/kg
- Target
- Rattus norvegicus
- Assay
- Not reported by source
OtherPositive observation
Record detail Table 3: R18D 1100 nmol/kg CL = 1.97 mL/min/kg.
- Measure
- other
- Value
- 1.97 mL/min/kg
- Target
- Rattus norvegicus
- Assay
- Not reported by source
OtherPositive observation
Record detail Table 3: R18D 325 nmol/kg λz = 0.53 1/h.
- Measure
- other
- Value
- 0.53 1/h
- Target
- Rattus norvegicus
- Assay
- Not reported by source
OtherPositive observation
Record detail Table 3: R18D 650 nmol/kg λz = 0.57 1/h.
- Measure
- other
- Value
- 0.57 1/h
- Target
- Rattus norvegicus
- Assay
- Not reported by source
OtherPositive observation
Record detail Table 3: R18D 1100 nmol/kg λz = 0.58 1/h.
- Measure
- other
- Value
- 0.58 1/h
- Target
- Rattus norvegicus
- Assay
- Not reported by source
Metabolic/Cardiovascular 6 records
PMC13239245
6 observationsMetabolic/CardiovascularAntibacterialPositive observation
Record detail Table 1: R18D 325 nmol/kg reduced infarct volume by 47.2% (p=0.0003). Total infarct volume 149.4 ± 70.05 mm3 vs Vehicle Saline 283.09 ± 50.28 mm3.
- Measure
- percent_inhibition
- Value
- 47.2%
- Target
- Rattus norvegicus
- Assay
- Not reported by source
Metabolic/CardiovascularAntibacterialPositive observation
Record detail Table 1: R18D 650 nmol/kg reduced infarct volume by 28.4% (p=0.008). Total infarct volume 202.6 ± 64.94 mm3 vs Vehicle Saline 283.09 ± 50.28 mm3.
- Measure
- percent_inhibition
- Value
- 28.4%
- Target
- Rattus norvegicus
- Assay
- Not reported by source
Metabolic/CardiovascularAntibacterialPositive observation
Record detail Table 1: R18D 1100 nmol/kg reduced infarct volume by 27.9% (p=0.003). Total infarct volume 204.1 ± 48.26 mm3 vs Vehicle Saline 283.09 ± 50.28 mm3.
- Measure
- percent_inhibition
- Value
- 27.9%
- Target
- Rattus norvegicus
- Assay
- Not reported by source
Metabolic/CardiovascularAntibacterialPositive observation
Record detail Table 1 and text: R18D 325 nmol/kg reduced hemisphere swelling by 5.6% (p=0.15). Hemisphere swelling 108.29 ± 10.53% vs Vehicle Saline 114.76 ± 7.36%.
- Measure
- percent_inhibition
- Value
- 5.6%
- Target
- Rattus norvegicus
- Assay
- Not reported by source
Metabolic/CardiovascularAntibacterialPositive observation
Record detail Table 1 and text: R18D 650 nmol/kg reduced hemisphere swelling by 8.3% (p=0.01). Hemisphere swelling 105.26 ± 7.23% vs Vehicle Saline 114.76 ± 7.36%.
- Measure
- percent_inhibition
- Value
- 8.3%
- Target
- Rattus norvegicus
- Assay
- Not reported by source
Metabolic/CardiovascularAntibacterialPositive observation
Record detail Table 1 and text: R18D 1100 nmol/kg reduced hemisphere swelling by 4.5% (p=0.14). Hemisphere swelling 109.56 ± 7.25% vs Vehicle Saline 114.76 ± 7.36%.
- Measure
- percent_inhibition
- Value
- 4.5%
- Target
- Rattus norvegicus
- Assay
- Not reported by source
Toxicity 3 records
PMC13239245
3 observationsToxicityGeneral ToxicPositive observation
Record detail Table 2: R18D 325 nmol/kg group had 7.35% body weight loss from baseline (Day 0 to Day 1). Vehicle Saline group had 9.35% loss.
- Measure
- percent_inhibition
- Value
- 7.35%
- Target
- Rattus norvegicus
- Assay
- Not reported by source
ToxicityGeneral ToxicPositive observation
Record detail Table 2: R18D 650 nmol/kg group had 10.62% body weight loss from baseline (Day 0 to Day 1). Vehicle Saline group had 9.35% loss.
- Measure
- percent_inhibition
- Value
- 10.62%
- Target
- Rattus norvegicus
- Assay
- Not reported by source
ToxicityGeneral ToxicPositive observation
Record detail Table 2: R18D 1100 nmol/kg group had 9.97% body weight loss from baseline (Day 0 to Day 1). Vehicle Saline group had 9.35% loss.
- Measure
- percent_inhibition
- Value
- 9.97%
- Target
- Rattus norvegicus
- Assay
- Not reported by source
Citation and release provenance
Cite this identity as PepDiana record PEPDIA-PLP-002564, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.
Record updated: 2026-06-22T07:14:26.229247+00:00