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Paper-scoped peptide mentionSequence reported

M104

PMC12936117::PEP000001

Source publication

Enhanced meropenem activity by a microbiome derived peptide targeting oxacillinase 48 carbapenemase in carbapenem resistant Klebsiella pneumoniae isolates.

Scientific Reports · 2026

DOI 10.1038/s41598-026-37644-2 PMC12936117 PMID 41651947

Sequence status: reported
Standardization: Sequence ready
Source location: unknown
Activity records: 85

Sequence evidence

Reported molecular identity

MEAFIVSAFKHQAEGFKLHYK

MEAFIVSAFKHQAEGFKLHYK

Resolved peptide links

PEPDIA-PLP-001978

Experimental observations

Records linked to this mention

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp6, MIC of meropenem (µg/mL) in the presence of 0 µg/mL peptide = 4.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 4 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp6, MIC of meropenem (µg/mL) in the presence of 7 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp6, MIC of meropenem (µg/mL) in the presence of 15 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp6, MIC of meropenem (µg/mL) in the presence of 31 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp6, MIC of meropenem (µg/mL) in the presence of 62 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp6, MIC of meropenem (µg/mL) in the presence of 125 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp3, MIC of meropenem (µg/mL) in the presence of 0 µg/mL peptide = 8.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 8 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp3, MIC of meropenem (µg/mL) in the presence of 7 µg/mL peptide = 8.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 8 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp3, MIC of meropenem (µg/mL) in the presence of 15 µg/mL peptide = 8.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 8 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp3, MIC of meropenem (µg/mL) in the presence of 31 µg/mL peptide = 8.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 8 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp3, MIC of meropenem (µg/mL) in the presence of 62 µg/mL peptide = 8.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 8 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp3, MIC of meropenem (µg/mL) in the presence of 125 µg/mL peptide = 4.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 4 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp7, MIC of meropenem (µg/mL) in the presence of 0 µg/mL peptide = 8.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 8 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp7, MIC of meropenem (µg/mL) in the presence of 7 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp7, MIC of meropenem (µg/mL) in the presence of 15 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp7, MIC of meropenem (µg/mL) in the presence of 31 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp7, MIC of meropenem (µg/mL) in the presence of 62 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp7, MIC of meropenem (µg/mL) in the presence of 125 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp19, MIC of meropenem (µg/mL) in the presence of 0 µg/mL peptide = 8.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 8 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp19, MIC of meropenem (µg/mL) in the presence of 7 µg/mL peptide = 4.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 4 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp19, MIC of meropenem (µg/mL) in the presence of 15 µg/mL peptide = 4.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 4 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp19, MIC of meropenem (µg/mL) in the presence of 31 µg/mL peptide = 4.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 4 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp19, MIC of meropenem (µg/mL) in the presence of 62 µg/mL peptide = 4.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 4 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp19, MIC of meropenem (µg/mL) in the presence of 125 µg/mL peptide = 4.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 4 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp23, MIC of meropenem (µg/mL) in the presence of 0 µg/mL peptide = 8.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 8 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp23, MIC of meropenem (µg/mL) in the presence of 7 µg/mL peptide = 8.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 8 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp23, MIC of meropenem (µg/mL) in the presence of 15 µg/mL peptide = 8.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 8 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp23, MIC of meropenem (µg/mL) in the presence of 31 µg/mL peptide = 8.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 8 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp23, MIC of meropenem (µg/mL) in the presence of 62 µg/mL peptide = 4.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 4 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp23, MIC of meropenem (µg/mL) in the presence of 125 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp31, MIC of meropenem (µg/mL) in the presence of 0 µg/mL peptide = 8.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 8 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp31, MIC of meropenem (µg/mL) in the presence of 7 µg/mL peptide = 4.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 4 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp31, MIC of meropenem (µg/mL) in the presence of 15 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp31, MIC of meropenem (µg/mL) in the presence of 31 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp31, MIC of meropenem (µg/mL) in the presence of 62 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp31, MIC of meropenem (µg/mL) in the presence of 125 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp33, MIC of meropenem (µg/mL) in the presence of 0 µg/mL peptide = 8.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 8 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp33, MIC of meropenem (µg/mL) in the presence of 7 µg/mL peptide = 4.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 4 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp33, MIC of meropenem (µg/mL) in the presence of 15 µg/mL peptide = 4.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 4 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp33, MIC of meropenem (µg/mL) in the presence of 31 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp33, MIC of meropenem (µg/mL) in the presence of 62 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp33, MIC of meropenem (µg/mL) in the presence of 125 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp5, MIC of meropenem (µg/mL) in the presence of 0 µg/mL peptide = 16.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 16 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp5, MIC of meropenem (µg/mL) in the presence of 7 µg/mL peptide = 16.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 16 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp5, MIC of meropenem (µg/mL) in the presence of 15 µg/mL peptide = 16.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 16 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp5, MIC of meropenem (µg/mL) in the presence of 31 µg/mL peptide = 16.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 16 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp5, MIC of meropenem (µg/mL) in the presence of 62 µg/mL peptide = 16.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 16 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp5, MIC of meropenem (µg/mL) in the presence of 125 µg/mL peptide = 8.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 8 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp112, MIC of meropenem (µg/mL) in the presence of 0 µg/mL peptide = 16.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 16 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp112, MIC of meropenem (µg/mL) in the presence of 7 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp112, MIC of meropenem (µg/mL) in the presence of 15 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp112, MIC of meropenem (µg/mL) in the presence of 31 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp112, MIC of meropenem (µg/mL) in the presence of 62 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp112, MIC of meropenem (µg/mL) in the presence of 125 µg/mL peptide = 2.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 2 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp121, MIC of meropenem (µg/mL) in the presence of 0 µg/mL peptide = 128.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 128 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp121, MIC of meropenem (µg/mL) in the presence of 7 µg/mL peptide = 16.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 16 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp121, MIC of meropenem (µg/mL) in the presence of 15 µg/mL peptide = 16.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 16 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp121, MIC of meropenem (µg/mL) in the presence of 31 µg/mL peptide = 8.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 8 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp121, MIC of meropenem (µg/mL) in the presence of 62 µg/mL peptide = 8.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 8 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Positive observation

Table 1: Isolate Kp121, MIC of meropenem (µg/mL) in the presence of 125 µg/mL peptide = 8.

Mention PMC12936117::PEP000001PMC12936117table

Measure: MIC
Value: 8 µg/mL
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 2: Isolate Kp5, Meropenem MBIC (µg/mL) = 256.

Mention PMC12936117::PEP000001PMC12936117table

Measure: other
Value: 256 (MBIC)
Target: Klebsiella pneumoniae
Assay: Crystal violet staining (biofilm inhibition assay)

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 2: Isolate Kp5, Meropenem+Peptide MBIC (µg/mL) = 128, [Peptide] (µg/mL) = 50, 100, and 200.

Mention PMC12936117::PEP000001PMC12936117table

Measure: other
Value: 128 (MBIC)
Target: Klebsiella pneumoniae
Assay: Crystal violet staining (biofilm inhibition assay)

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 2: Isolate Kp6, Meropenem MBIC (µg/mL) = 256.

Mention PMC12936117::PEP000001PMC12936117table

Measure: other
Value: 256 (MBIC)
Target: Klebsiella pneumoniae
Assay: Crystal violet staining (biofilm inhibition assay)

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 2: Isolate Kp6, Meropenem+Peptide MBIC (µg/mL) = 128, [Peptide] (µg/mL) = 200.

Mention PMC12936117::PEP000001PMC12936117table

Measure: other
Value: 128 (MBIC)
Target: Klebsiella pneumoniae
Assay: Crystal violet staining (biofilm inhibition assay)

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 2: Isolate Kp33, Meropenem MBIC (µg/mL) = 256.

Mention PMC12936117::PEP000001PMC12936117table

Measure: other
Value: 256 (MBIC)
Target: Klebsiella pneumoniae
Assay: Crystal violet staining (biofilm inhibition assay)

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 2: Isolate Kp33, Meropenem+Peptide MBIC (µg/mL) = 128, [Peptide] (µg/mL) = 100.

Mention PMC12936117::PEP000001PMC12936117table

Measure: other
Value: 128 (MBIC)
Target: Klebsiella pneumoniae
Assay: Crystal violet staining (biofilm inhibition assay)

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 2: Isolate Kp112, Meropenem MBIC (µg/mL) = 512.

Mention PMC12936117::PEP000001PMC12936117table

Measure: other
Value: 512 (MBIC)
Target: Klebsiella pneumoniae
Assay: Crystal violet staining (biofilm inhibition assay)

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 2: Isolate Kp112, Meropenem+Peptide MBIC (µg/mL) = 256, [Peptide] (µg/mL) = 200.

Mention PMC12936117::PEP000001PMC12936117table

Measure: other
Value: 256 (MBIC)
Target: Klebsiella pneumoniae
Assay: Crystal violet staining (biofilm inhibition assay)

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 2: Isolate Kp121, Meropenem MBIC (µg/mL) = 512.

Mention PMC12936117::PEP000001PMC12936117table

Measure: other
Value: 512 (MBIC)
Target: Klebsiella pneumoniae
Assay: Crystal violet staining (biofilm inhibition assay)

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 2: Isolate Kp121, Meropenem+Peptide MBIC (µg/mL) = 256, [Peptide] (µg/mL) = 200.

Mention PMC12936117::PEP000001PMC12936117table

Measure: other
Value: 256 (MBIC)
Target: Klebsiella pneumoniae
Assay: Crystal violet staining (biofilm inhibition assay)

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: Isolate Kp5, Meropenem MBEC (µg/mL) = 2048.

Mention PMC12936117::PEP000001PMC12936117table

Measure: other
Value: 2048 (MBEC)
Target: Klebsiella pneumoniae
Assay: MTT assay (biofilm eradication assay)

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: Isolate Kp5, Meropenem+Peptide MBEC (µg/mL) = 1024. Table footnote: The concentration of peptide was 200 (µg/mL).

Mention PMC12936117::PEP000001PMC12936117table

Measure: other
Value: 1024 (MBEC)
Target: Klebsiella pneumoniae
Assay: MTT assay (biofilm eradication assay)

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: Isolate Kp33, Meropenem MBEC (µg/mL) = 2048.

Mention PMC12936117::PEP000001PMC12936117table

Measure: other
Value: 2048 (MBEC)
Target: Klebsiella pneumoniae
Assay: MTT assay (biofilm eradication assay)

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: Isolate Kp33, Meropenem+Peptide MBEC (µg/mL) = 1024. Table footnote: The concentration of peptide was 200 (µg/mL).

Mention PMC12936117::PEP000001PMC12936117table

Measure: other
Value: 1024 (MBEC)
Target: Klebsiella pneumoniae
Assay: MTT assay (biofilm eradication assay)

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: Isolate Kp6, Meropenem MBEC (µg/mL) = 512.

Mention PMC12936117::PEP000001PMC12936117table

Measure: other
Value: 512 (MBEC)
Target: Klebsiella pneumoniae
Assay: MTT assay (biofilm eradication assay)

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: Isolate Kp6, Meropenem+Peptide MBEC (µg/mL) = 256. Table footnote: The concentration of peptide was 200 (µg/mL).

Mention PMC12936117::PEP000001PMC12936117table

Measure: other
Value: 256 (MBEC)
Target: Klebsiella pneumoniae
Assay: MTT assay (biofilm eradication assay)

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: Isolate Kp112, Meropenem MBEC (µg/mL) = 2048.

Mention PMC12936117::PEP000001PMC12936117table

Measure: other
Value: 2048 (MBEC)
Target: Klebsiella pneumoniae
Assay: MTT assay (biofilm eradication assay)

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: Isolate Kp112, Meropenem+Peptide MBEC (µg/mL) = 2048. Table footnote: The concentration of peptide was 200 (µg/mL).

Mention PMC12936117::PEP000001PMC12936117table

Measure: other
Value: 2048 (MBEC)
Target: Klebsiella pneumoniae
Assay: MTT assay (biofilm eradication assay)

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: Isolate Kp121, Meropenem MBEC (µg/mL) = 2048.

Mention PMC12936117::PEP000001PMC12936117table

Measure: other
Value: 2048 (MBEC)
Target: Klebsiella pneumoniae
Assay: MTT assay (biofilm eradication assay)

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: Isolate Kp121, Meropenem+Peptide MBEC (µg/mL) = 2048. Table footnote: The concentration of peptide was 200 (µg/mL).

Mention PMC12936117::PEP000001PMC12936117table

Measure: other
Value: 2048 (MBEC)
Target: Klebsiella pneumoniae
Assay: MTT assay (biofilm eradication assay)

Source publication

ToxicityCytotoxicPositive observation

Cells treated with 200 µg/mL of peptide M104 for 24 h maintained a mean cell viability of 99.6%, which was not statistically different from the untreated control (p-value > 0.05).

Mention PMC12936117::PEP000001PMC12936117text

Measure: cell_viability
Value: 99.6%
Target: HDFa
Assay: MTT assay

Source publication

ToxicityCytotoxicPositive observation

Following 48 h of incubation with 200 µg/mL peptide M104, the mean cell viability significantly reduced to 90.1% (p-value < 0.05) compared to the untreated control.

Mention PMC12936117::PEP000001PMC12936117text

Measure: cell_viability
Value: 90.1%
Target: HDFa
Assay: MTT assay

Source publication

ToxicityHemolyticNegative / threshold

In the hemolysis assay, peptide M104 showed no detectable hemolytic activity at the highest concentration tested (200 µg/mL).

Mention PMC12936117::PEP000001PMC12936117text

Measure: hemolysis
Value: no detectable hemolytic activity
Target: Not reported by source
Assay: Hemolysis assay (hemoglobin release at 540 nm)

Source publication

AntimicrobialAnti-Gram-Negative / threshold

Notably, the peptide did not enhance meropenem’s activity when tested against the ten carbapenemase-negative (presumably blaOXA-48 negative) isolates.

Mention PMC12936117::PEP000001PMC12936117text

Measure: MIC
Value: no enhancement
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

AntimicrobialAnti-Gram-Negative / threshold

The peptide exhibited no intrinsic antibacterial activity when used alone against the bacteria, either in planktonic or in the biofilm state of living.

Mention PMC12936117::PEP000001PMC12936117text

Measure: MIC
Value: no intrinsic antibacterial activity
Target: Klebsiella pneumoniae
Assay: Broth microdilution (checkerboard assay)

Source publication

Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.