Primary experimental recordNegative / threshold

PMC12936117::ACT037661

M104

Evidence text

Paper-level observation

Notably, the peptide did not enhance meropenem’s activity when tested against the ten carbapenemase-negative (presumably blaOXA-48 negative) isolates.

textConfidence: medium

Assay observation

Activity

Antimicrobial

Subtype

Anti-Gram-

Measure

MIC

Comparator

Raw observation

no enhancement

Normalized measurement

=48

Value minimum

Not reported by source

Value maximum

Not reported by source

Target

Klebsiella pneumoniae

Assay method

Broth microdilution (checkerboard assay)

Sequence

MEAFIVSAFKHQAEGFKLHYK

Standardization

ready simple

Source publication

Enhanced meropenem activity by a microbiome derived peptide targeting oxacillinase 48 carbapenemase in carbapenem resistant Klebsiella pneumoniae isolates.

Scientific Reports · 2026

DOI 10.1038/s41598-026-37644-2 PMC12936117

Parent mention

Related peptide identities

PEPDIA-PLP-001978

Release PepDiana-V1-20260620. The stable record URL can be cited directly in supplementary material and downstream analyses.