Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 976
Aptamer sequence: ACGCTCGGATGCCACTACAGGGGGGTGGTCCTGAGGGTGGTGTGGTTGGTTTGGTTTCCTCATGGACGTGCTGGTGAC
Target unique ID: Other-23
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_887 | AGC03 | Other | Gastric cancer cell-line MGC-803 | 5.22 nM | 4.5 g/L glucose, 5 mM MgCl2, 2 mg/ml BSA and 0.2 mg/ml yeast tRNA dissolved in PBS buffer | 24501772 |
Structure information of aptamer
| Aptamer Sequence: | ACGCTCGGATGCCACTACAGGGGGGTGGTCCTGAGGGTGGTGTGGTTGGTTTGGTTTCCTCATGGACGTGCTGGTGAC |
| The optimal secondary structure in dot-bracket notation: | .(((.(((((((((((.(((((......)))))..)))))))).(((.((..((...))..)).)))...)))))).. |
| The centroid secondary structure in dot-bracket notation: | .(((.(((((((((((.(((((......)))))..)))))))).(((.((..((...))..)).)))...)))))).. |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_887 | Description | AGC03 |
| Aptamer chemistry | DNA | Length | 78 nt |
| GC content | 60.3% | Molecular weight | 24,321.47 Da |
| Molarity of 1 μg/μl solution | 41.12 μM | Number of G-quadruplexes | 2 |
| G-Score | 20 | Function | Targeted binding |
| Sequence | ACGCTCGGATGCCACTACAGGGGGGTGGTCCTGAGGGTGGTGTGGTTGGTTTGGTTTCCTCATGGACGTGCTGGTGAC | ||
| Applications | Binding to gastric cancer cell | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Target ID | Other-23 | Name | Gastric cancer cell-line MGC-803 |
Activity data
|
No relevant experimental diagram |
Interaction ID | 974 |
| Target type | Other | |
| Target unique ID | Other-21 | |
| Activity | 16.49 nM | |
| Binding Conditions/Buffer | 4.5 g/L glucose, 5 mM MgCl2, 2 mg/ml BSA and 0.2 mg/ml yeast tRNA dissolved in PBS buffer |
|
| Assay | N/A |
|
| PubMed ID | 24501772 | |
|
No relevant experimental diagram |
Interaction ID | 975 |
| Target type | Other | |
| Target unique ID | Other-22 | |
| Activity | 73.90 nM | |
| Binding Conditions/Buffer | 4.5 g/L glucose, 5 mM MgCl2, 2 mg/ml BSA and 0.2 mg/ml yeast tRNA dissolved in PBS buffer |
|
| Assay | N/A |
|
| PubMed ID | 24501772 | |
|
No relevant experimental diagram |
Interaction ID | 976 |
| Target type | Other | |
| Target unique ID | Other-23 | |
| Activity | 5.22 nM | |
| Binding Conditions/Buffer | 4.5 g/L glucose, 5 mM MgCl2, 2 mg/ml BSA and 0.2 mg/ml yeast tRNA dissolved in PBS buffer |
|
| Assay | N/A |
|
| PubMed ID | 24501772 | |
|
No relevant experimental diagram |
Interaction ID | 977 |
| Target type | Other | |
| Target unique ID | Other-24 | |
| Activity | 19.29 nM | |
| Binding Conditions/Buffer | 4.5 g/L glucose, 5 mM MgCl2, 2 mg/ml BSA and 0.2 mg/ml yeast tRNA dissolved in PBS buffer |
|
| Assay | N/A |
|
| PubMed ID | 24501772 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_140 | DNA | GGCAGGAAGACAAACACGATGGGGGGGTATGATTTGATGTGGTTGTTGCATGATCGTGGTCTGTGGTGCTGT | |
| Apta_1178 | DNA | AGCGTCGAATACCACTACAGGGGATGCGAAGTTCCGCGGTCGAGTATATGATACATCCATCTAATGGAGCTCGTGGTCAG | |
| Apta_235 | DNA | AGCAGCACAGAGGTCAGATGTGGTTCGATGCTGCAAGGTGTTGTCATTTGGCATATGTTACCTATGCGTGCTACCGTGAA | |
| Apta_771 | DNA | GAATTCCGTCGGACAGCGGTATGCATGGGAGGTTCTGGAGGGGGTGGGTTGGCGTGCGTTCCAGATGGACGAATATCGTCTCCC | |
| Apta_464 | DNA | GTCAGATTCCACTATAGTAGGTTGGGTAGGGTGGTCGCAGTGGATGATATGTCGTAGGGG | |
| Apta_878 | DNA | TCGCACATTCCGCTTCTACCGGGGGGGTCGAGCTGAGTGGATGCGAATCTGTGGGTGGGCTTCGCACACACGGACTTAC | |
| Apta_455 | DNA | AGCTCCAGAAGATAAATTACAGGGGCCGGGGTGGCTCAGGCAAGGGGTTGACCTGTCGTAGGGATTGTTTTAACAACTAGGATACTATGACCCC | |
| Apta_1137 | DNA | GCCGAGATTGCACTTACTATCTCAAGAAGAGTAGTAAGAGGAGTGGGTGGTTATGAGTAAGTTGTATGTGGTAATTGAATAAGCTGGTATGCGC | |
| Apta_45 | DNA | CGGGTGGGAGTTGTGGGGGGGGGTGGGAGGGTTCTTTGTTTGATCTTTCTCGCTGCCTGGCCCTAGAGTG | |
| Apta_78 | DNA | ATCTCGACTAGTCATAGGGGGCGCGAACATACGCGGTTGGTGTGGTTGGCTGACAATACTCGT | |
| Apta_79 | DNA | ATCTCGAGTCATAGGGGGCGCGAACATACGCGGTTGGTGTGGTTGGCTGACTCGT | |
| Apta_794 | DNA | ATCCAGAGTGACGCAGCAAGGAGATTCGAGGGGGAAGGTTTGTTATAGGGGTTAATGGACACGGTGGCTTAGT | |
| Apta_950 | DNA | CACCTAATACGACTCACTATAGCGGATCCGAAGGGGGCGCGAGGTGTAAGGGTGTGGGGTGGTGGGTGGGCCTGGCTCGAACAAGCTTGC | |
| Apta_281 | DNA | CCGTAATACGACTCACTATAGGGGAGCTCGGTACCGAATTCATGTTGGTAGTTGGCTTGTGTTCGTGTGTTAAGCTTTCAGAGAGGATCCTT | |
| Apta_1131 | DNA | GCCGAGATTGCACTTACTATCTCAAGAAGGGTAGTAAGAGGAGTGGGTGATTATGGGTAAGTTGTATGAGGTAATTGAATAAGCTGGTATGCGC | |
| Apta_773 | DNA | GAATTCAGTCGGACAGCGGTGGTGCTTGTGTATGGGGGTGGTTGGTGGGTTTTATGCTGCTGGATGGACGAATATCGTCTCCC | |
| Apta_587 | DNA | GGAATGGATCCACATCCATGGATGGGCAATGCGGGGTGGAGAATGGTTGCCGCACTTCGGCTTCACTGCAGACTTGACGAAGCTT | |
| Apta_44 | DNA | TCTCGGACGCGTGTGGTCGGGTGGGAGTTGTGGGGGGGGGTGGGAGGGTTCTTTGTTTGATCTTTCTCGCTGCCTGGCCCTAGAGTG | |
| Apta_734 | DNA | TCCTCGATGCACCAGTTCACCTTATTTGCTTCTTCTCTCTGTTCTGACTGGGTGCTGAGGA | |
| Apta_810 | DNA | ACAGCATCCCCATGTGAACAATCGCATTGTGATTGTTACGGTTTCCGCCTCATGGACGTGCTG |
DEV TOOL
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