Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 45
Aptamer sequence: CGGGTGGGAGTTGTGGGGGGGGGTGGGAGGGTTCTTTGTTTGATCTTTCTCGCTGCCTGGCCCTAGAGTG
Target unique ID: O95994
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_45 C14B0 Protein AGR2_HUMAN 8.5 nM PBS with 137 mM NACl, 2.7 mM KCl, 10 mM NaHPO4, and 2.0 mM KH2PO4 23029506
Structure information of aptamer
Aptamer Sequence: CGGGTGGGAGTTGTGGGGGGGGGTGGGAGGGTTCTTTGTTTGATCTTTCTCGCTGCCTGGCCCTAGAGTG
The optimal secondary structure in dot-bracket notation: ..........((.(((((((.((((((((((.((.......)).)))))))))).))...))))).))..
The centroid secondary structure in dot-bracket notation: .....................((((((((((..(.......)..))))))))))................
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_45 Description C14B0
Aptamer chemistry DNA Length 70 nt
GC content 61.4% Molecular weight 21,911.91 Da
Molarity of 1 μg/μl solution 45.64 μM Number of G-quadruplexes 3
G-Score 64 Function Aptasensor
Sequence CGGGTGGGAGTTGTGGGGGGGGGTGGGAGGGTTCTTTGTTTGATCTTTCTCGCTGCCTGGCCCTAGAGTG
Applications Selective and sensitive detection of AGR2
Target information
Type Detail Type Detail
Uniprot ID O95994 Protein name Anterior gradient protein 2 homolog (AG-2) (hAG-2) (HPC8) (Secreted cement gland protein XAG-2 homolog)
Gene name(s) AGR2 AG2 UNQ515/PRO1030 Organism Anterior gradient protein 2 homolog (AG-2) (hAG-2) (HPC8) (Secreted cement gland protein XAG-2 homolog)
Status reviewed in uniprot database Length 175
Mass 19,979 Activity regulation N/A
Involvement in disease N/A Catalytic activity N/A
PDB ID(s)
2LNS;2LNT;
Function Required for MUC2 post-transcriptional synthesis and secretion.
Activity data

No relevant experimental diagram

 Interaction ID 45
Target type Protein
Target unique ID O95994
Activity 8.5 nM
Binding Conditions/Buffer

PBS with 137 mM NACl, 2.7 mM KCl, 10 mM NaHPO4, and 2.0 mM KH2PO4
Assay

N/A
PubMed ID 23029506
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_44 DNA TCTCGGACGCGTGTGGTCGGGTGGGAGTTGTGGGGGGGGGTGGGAGGGTTCTTTGTTTGATCTTTCTCGCTGCCTGGCCCTAGAGTG
80.46%
Apta_611 DNA GCTGCGAGGTGGGTGGGTGGGAGCAATTGGTCCTTGCTTAGCTTCTACGGTGGGCTATCT 57.14%
Apta_609 DNA GCTGCGAGGTGGGTGGGTGGGAGCAATTGGTCCTCGCTTAGCTTCTACGGTGGGCTATCT 55.71%
Apta_610 DNA GCTGTGAGGTGGGTGGGTGGGAGCAATTGGTCCTCGCTTAGCTTCTACGGTGGGCTATCT 55.71%
Apta_887 DNA ACGCTCGGATGCCACTACAGGGGGGTGGTCCTGAGGGTGGTGTGGTTGGTTTGGTTTCCTCATGGACGTGCTGGTGAC 55.13%
Apta_356 DNA CGGGGGGTACGTGCCCGTGTTGCTCGGCGGCCCCCTCGCTTATTTTTGTGTGCCCTTT 54.29%
Apta_487 DNA CGGGGAGTTGGGAGGGGGGGCAAAGCCTGTGTATTTATCTTCTGT 54.29%
Apta_708 DNA CGTACGGAATTCGCTAGCGGGCGGGGGTGCTGGGGGAATGGAGTGCTGCGTGCTGCGGGGATCCGAGCTCCACGTG 53.95%
Apta_616 DNA GGTGCGGGTAGGGATGAGGGCGGGTCGGGTTGAGTGTGAGCTTAGGGGtGGCGGATCTAC 52.86%
Apta_1011 DNA GCTGTGTGACTCCTGCAATGGTAGCGGGTAGGGGAGGGAGGGTGAATGGAGGATGTTCATGGCAGCTGTATCTTGTCTCC 52.50%
Apta_572 DNA CCGTAACCCTGCGGGGGGGGGAGAAGGCAATGGGGGACAACTCGCCGGTAGCCATCCATAT 51.43%
Apta_746 DNA AGAGTGGGGGGGTGGGTGGATTTGACAGGTGGCATGCTGGAGAGT 51.43%
Apta_941 DNA CGGGTGCCTTAAAGTGTAGGTGGGAGGGGGATGATTATGTACGATCAAGT 51.43%
Apta_979 DNA ATGAGTAGTGCGGAGGGATGTGAATACTGACGCGGTCATAGTCGCTGTTGTACCATTGA 51.43%
Apta_1071 DNA TTGAAGTGACTCCGCACTGGGTGGGTGGGAGGGTCGTGCGGCTGGTCATAGCAGGGT 51.43%
Apta_1185 DNA CAGGGGGTTTTGGTGGGGGGGGCTGGGTTGTCTTGGGGGTGGGCT 51.43%
Apta_1230 DNA GGCGATAGGCAGTGTTGCGGGGTCGGAGAGCGAGGTAATAGCGTGTATGGGTGCTGTGTG 51.43%
Apta_832 DNA CCGGAGGTGGGTGAGGTCTGCGGCAGGCTGTGTGGGTGGACCGGAGGGGGGTGAGGTCTGCGGCAGGCTGTGTGGGTGGA 51.25%
Apta_490 DNA GGGAGACAAGAATAAACGCTCAAGGGCGTGGTGGGTGGGGTACTAATAATGTGCGTTTGTTCGACAGGAGGCTCACAACAGGC 50.60%
Apta_173 DNA AGCAGCACAGAGGTCAGATGGCAGGTTTCGACGTACAATGCTATGGAGGCTTTATGATCGCCTATGCGTGCTACCGTGAA 50.00%

ABOUT

AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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