Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 44
Aptamer sequence: TCTCGGACGCGTGTGGTCGGGTGGGAGTTGTGGGGGGGGGTGGGAGGGTTCTTTGTTTGATCTTTCTCGCTGCCTGGCCCTAGAGTG
Target unique ID: O95994
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_44 C14B Protein AGR2_HUMAN 13.1 nM PBS with 137 mM NACl, 2.7 mM KCl, 10 mM NaHPO4, and 2.0 mM KH2PO4 23029506
Structure information of aptamer
Aptamer Sequence: TCTCGGACGCGTGTGGTCGGGTGGGAGTTGTGGGGGGGGGTGGGAGGGTTCTTTGTTTGATCTTTCTCGCTGCCTGGCCCTAGAGTG
The optimal secondary structure in dot-bracket notation: .(((..((.((......)).))..)))((.(((((((.((((((((((.((.......)).)))))))))).))...))))).))..
The centroid secondary structure in dot-bracket notation: ......((.((......)).))......(.(((((((.((((((((((.((.......)).)))))))))).))...))))).)...
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_44 Description C14B
Aptamer chemistry DNA Length 87 nt
GC content 62.1% Molecular weight 27,207.25 Da
Molarity of 1 μg/μl solution 36.75 μM Number of G-quadruplexes 3
G-Score 64 Function Aptasensor
Sequence TCTCGGACGCGTGTGGTCGGGTGGGAGTTGTGGGGGGGGGTGGGAGGGTTCTTTGTTTGATCTTTCTCGCTGCCTGGCCCTAGAGTG
Applications Selective and sensitive detection of AGR2
Target information
Type Detail Type Detail
Uniprot ID O95994 Protein name Anterior gradient protein 2 homolog (AG-2) (hAG-2) (HPC8) (Secreted cement gland protein XAG-2 homolog)
Gene name(s) AGR2 AG2 UNQ515/PRO1030 Organism Anterior gradient protein 2 homolog (AG-2) (hAG-2) (HPC8) (Secreted cement gland protein XAG-2 homolog)
Status reviewed in uniprot database Length 175
Mass 19,979 Activity regulation N/A
Involvement in disease N/A Catalytic activity N/A
PDB ID(s)
2LNS;2LNT;
Function Required for MUC2 post-transcriptional synthesis and secretion.
Activity data

No relevant experimental diagram

 Interaction ID 44
Target type Protein
Target unique ID O95994
Activity 13.1 nM
Binding Conditions/Buffer

PBS with 137 mM NACl, 2.7 mM KCl, 10 mM NaHPO4, and 2.0 mM KH2PO4
Assay

N/A
PubMed ID 23029506
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_45 DNA CGGGTGGGAGTTGTGGGGGGGGGTGGGAGGGTTCTTTGTTTGATCTTTCTCGCTGCCTGGCCCTAGAGTG
80.46%
Apta_887 DNA ACGCTCGGATGCCACTACAGGGGGGTGGTCCTGAGGGTGGTGTGGTTGGTTTGGTTTCCTCATGGACGTGCTGGTGAC 54.02%
Apta_611 DNA GCTGCGAGGTGGGTGGGTGGGAGCAATTGGTCCTTGCTTAGCTTCTACGGTGGGCTATCT 52.87%
Apta_708 DNA CGTACGGAATTCGCTAGCGGGCGGGGGTGCTGGGGGAATGGAGTGCTGCGTGCTGCGGGGATCCGAGCTCCACGTG 52.87%
Apta_832 DNA CCGGAGGTGGGTGAGGTCTGCGGCAGGCTGTGTGGGTGGACCGGAGGGGGGTGAGGTCTGCGGCAGGCTGTGTGGGTGGA 52.87%
Apta_609 DNA GCTGCGAGGTGGGTGGGTGGGAGCAATTGGTCCTCGCTTAGCTTCTACGGTGGGCTATCT 51.72%
Apta_610 DNA GCTGTGAGGTGGGTGGGTGGGAGCAATTGGTCCTCGCTTAGCTTCTACGGTGGGCTATCT 51.72%
Apta_864 DNA CTCCTCTGACTGTAACCACGACTAGGACGCTTGGGAGGGGGGGTGGGGTGTCCGGTCGCGGCATAGGTAGTCCAGAAGCC 51.72%
Apta_1011 DNA GCTGTGTGACTCCTGCAATGGTAGCGGGTAGGGGAGGGAGGGTGAATGGAGGATGTTCATGGCAGCTGTATCTTGTCTCC 51.72%
Apta_1229 DNA CACGGGCAGAGGGATAGGTTGTTGACGGGGCTGGTGGGTGGGTGCGCTCGCGCTATCGTGG 51.72%
Apta_67 DNA AGATGCCTGTCGAGCATGCTGTTGTGGTAGGGTTAGGGATGGTAGCGGTTGTAGCTAAACTGCTTTGTCGACGGG 50.57%
Apta_794 DNA ATCCAGAGTGACGCAGCAAGGAGATTCGAGGGGGAAGGTTTGTTATAGGGGTTAATGGACACGGTGGCTTAGT 50.57%
Apta_982 DNA ATGACGGGGGTCTAGGCAAGTAATAACGGGGGCAAGCTTTTCTATCTCGTTCTAGGGTA 50.57%
Apta_1071 DNA TTGAAGTGACTCCGCACTGGGTGGGTGGGAGGGTCGTGCGGCTGGTCATAGCAGGGT 50.57%
Apta_1273 DNA TCCCTCCTGTTGGTTTGGGATGGTGGCGACTATCTGATTGTTTGACTCCCCGTAGGGG 50.57%
Apta_151 DNA GCAATGGTACGGTACTTCCGCGGTCCGGGGTGGGTGGGTGGTGGGGGGTGCGGGGGGGCGGCCGCAAAAGTGCACGCTACTTTGCTAA 50.00%
Apta_412 DNA CACGACTCTCACCTCATAGCtGGTGGGGTTCCCGGGAGGGCGGCTACGGGTTCCGTAATCAGATTTGTGTCTGGTTCTGTAGACGGCTTG 50.00%
Apta_102 DNA AGCAGCACAGAGGTCAGATGCGTTTTTTACGGCTGGCAACGGAAGTCAGTTTATTCTTCACCTATGCGTGCTACCGTGAA 49.43%
Apta_102 DNA AGCAGCACAGAGGTCAGATGCGTTTTTTACGGCTGGCAACGGAAGTCAGTTTATTCTTCACCTATGCGTGCTACCGTGAA 49.43%
Apta_178 DNA AGCAGCACAGAGGTCAGATGCGGTATGCTGGGTCATCTAACTGGGGATATTCTGATATTGCCTATGCGTGCTACCGTGAA 49.43%

ABOUT

AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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