Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 660
Aptamer sequence: AAGCTTTTTTGACTGACTGCAGCGATTCTTGATCGCCACGGTCTGGAAAAAGAG
Target unique ID: 90479
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_622 | SS4-54 | Molecule | Isocarbophos | 0.9 μM | 300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3 | 22261866 |
Structure information of aptamer
| Aptamer Sequence: | AAGCTTTTTTGACTGACTGCAGCGATTCTTGATCGCCACGGTCTGGAAAAAGAG |
| The optimal secondary structure in dot-bracket notation: | ...(((((((....(((((..((((((...))))))..)))))..))))))).. |
| The centroid secondary structure in dot-bracket notation: | ...(((((((....(((((..((((((...))))))..)))))..))))))).. |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_622 | Description | SS4-54 |
| Aptamer chemistry | DNA | Length | 54 nt |
| GC content | 46.3% | Molecular weight | 16,675.71 Da |
| Molarity of 1 μg/μl solution | 59.97 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Aptasensor |
| Sequence | AAGCTTTTTTGACTGACTGCAGCGATTCTTGATCGCCACGGTCTGGAAAAAGAG | ||
| Applications | Analysis and neutralization of the residues of the four organophosphorus pesticides | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| PubChem ID | 90479 | Molecular name | Isocarbophos |
| Molecular formula | C11H16NO4PS | Molecular weight | 289.29 |
| IUPAC name | propan-2-yl 2-[amino(methoxy)phosphinothioyl]oxybenzoate | InChIKey | YFVOXLJXJBQDEF-UHFFFAOYSA-N |
| LogP | 2.46 | Topological polar surface area | 70.78 |
| Hydrogen bond acceptor | 5 | Hydrogen bond donor | 1 |
Synonym(s): Isocarbophos; 24353-61-5; Optunal; Isocarbofos; propan-2-yl 2-[amino(methoxy)phosphinothioyl]oxybenzoate; Isopropyl 2-((aminomethoxyphosphinothioyl)oxy)benzoate; O-Methylphosphoramidothioate, O-ester with isopropyl salicylate; CHEBI:38704; Benzoic acid, 2-((aminomethoxyphosphinothioyl)oxy)-, 1-methylethyl ester; Benzoic acid, 2-[(aminomethoxyphosphinothioyl)oxy]-, 1-methylethyl ester; isopropyl O-(methoxyaminothiophosphoryl)salicylate; propan-2-yl 2-{[amino(methoxy)phosphorothioyl]oxy}benzoate; Caswell No. 574B; Bay 93820; EINECS 246-192-1; EPA Pesticide Chemical Code 574300; BRN 2946521; C11H16NO4PS; AI3-27659; O-Methyl phosphoramidothioate, O-ester with isopropyl salicylate; O-Methylphosphoramidothioate; DSSTox_CID_22063; DSSTox_RID_79913; DSSTox_GSID_42063; SCHEMBL117792; CHEMBL3185588; DTXSID7042063; O-ester with isopropyl salicylate; Isopropyl salicylate O-ester with O-methylphosphoramidothioate; ZAA35361; Tox21_301328; BAY-93820; Salicylic acid, isopropyl ester, ester with O-methyl phosphoramidothioate; Isocarbofos 1000 microg/mL in Acetone; Isocarbofos 10 microg/mL in Cyclohexane; NCGC00255827-01; Isocarbofos 100 microg/mL in Cyclohexane; O517; CAS-24353-61-5; Isocarbophos, PESTANAL(R), analytical standard; 353I615; Q-201253; isopropyl 2-(amino(methoxy)phosphorothioyloxy)benzoate; Q27117953; UNII-7741NPW06X component YFVOXLJXJBQDEF-KRWDZBQOSA-N; Pesticide1_Isocarbophos_C11H16NO4PS_Benzoic acid, 2-[(aminomethoxyphosphinothioyl)oxy]-, 1-methylethyl ester
Activity data
 |
Interaction ID | 660 |
| Target type | Molecule | |
| Target unique ID | 90479 | |
| Activity | 0.9 μM | |
| Binding Conditions/Buffer | 300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3 |
|
| Assay | Specifificity of SS2-55 and SS4-54 aptamers |
|
| PubMed ID | 22261866 | |
 |
Interaction ID | 752 |
| Target type | Molecule | |
| Target unique ID | 14210 | |
| Activity | 2 μM | |
| Binding Conditions/Buffer | 300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3 |
|
| Assay | Specifificity of SS2-55 and SS4-54 aptamers |
|
| PubMed ID | 22261866 | |
 |
Interaction ID | 766 |
| Target type | Molecule | |
| Target unique ID | 4790 | |
| Activity | 1.43 μM | |
| Binding Conditions/Buffer | 300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3 |
|
| Assay | Specifificity of SS2-55 and SS4-54 aptamers |
|
| PubMed ID | 22261866 | |
 |
Interaction ID | 770 |
| Target type | Molecule | |
| Target unique ID | 38779 | |
| Activity | 1.25 μM | |
| Binding Conditions/Buffer | 300 mM NaCl, 50 mM KCl, 10 mM MgCl2, 50 mM Tris/HCl, and pH 8.3 |
|
| Assay | Specifificity of SS2-55 and SS4-54 aptamers |
|
| PubMed ID | 22261866 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_621 | DNA | AAGCTTGCTTTATAGCCTGCAGCGATTCTTGATCGGAAAAGGCTGAGAGCTACGC | |
| Apta_510 | DNA | TGTAATTTGTCTGCAGCGGTTCTTGATCGCTGACACCATATTATGAAGA | |
| Apta_1061 | DNA | TATTTATTGAATGCTGTAATTTCGCCACGCGAAAGTAGG | |
| Apta_340 | DNA | TACTCAGGGCACTGCAAGCAATTGTGGTCCCAATGGGCTGAGTA | |
| Apta_348 | DNA | ACTTGCTCTGATGCGACAACCTTTTGCCCAGATAGTAAGT | |
| Apta_489 | DNA | GGGGTTAAATATTCCCACATTGCCTGCGCCAGTACAAATAG | |
| Apta_912 | DNA | TAGTATGGACTTGTCTTCTTGTCAGAGTCTGGCAGCACGT | |
| Apta_694 | DNA | ACTCACTATGGAAGAGATGGCGACATCTCTTCTCCGAGCCGGTCGAAATAGTGAGT | |
| Apta_451 | DNA | ATACCAGCTTATTCAATTGAGTAAGAGTGCACTATGTTTTACGAGCCGTTTCCTCGGCAGATAGTAAGTGCAATCT | |
| Apta_796 | DNA | GTGCTGGATGTCACCTCCACTCACCACCTCTTCTCCGCTCCTCGTCATGACACATCCAG | |
| Apta_57 | DNA | GCGGGTCGGTTGCTCGCTTCGCCCGATCGGTCTAAGGGTG | |
| Apta_163 | DNA | GCGCATGACCATTGATGTCTGCACCATCAGAGGCAGAG | |
| Apta_259 | DNA | GCAAGTATGAGCGCAGGAGTTAGGTCCCGTGGCGATGGGT | |
| Apta_260 | DNA | GACGTTAAGCTAGCAGGTGTTAGGTCCCGTGGTGATGAAT | |
| Apta_273 | DNA | ATAAGCTGAGCATCTTAGATCCCCGTCAAGGGCAGCGTAA | |
| Apta_274 | DNA | GATACTGAGCATCGTACATGATCCCGCAACGGGCAGTATT | |
| Apta_449 | DNA | CGCACTATGTTTTACGAGCCGTTTCCTCGGCAGATAGTAAGTGCG | |
| Apta_476 | DNA | CCTATCTTATTCGTTGCGGACTCCCCGGTCGGTATGTATG | |
| Apta_776 | DNA | AGTGGTCGAACTACACATCCTTGAACTGCGGAATTATCTAC | |
| Apta_778 | DNA | GAAGACGAGCGGCGAGTGTTATTACGCTTGGAAACAACCCC |
DEV TOOL
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