AptaDB: Result

Interaction ID: 1043

Aptamer sequence: CCCGAGGCACGAGGGGGAACGTATCGTCATGTGCCGGCCA

Target unique ID: P01266

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_960	T-3	Protein	THYG_HUMAN	4.03 μM	TGK, Tris-HCl, BBS, and PBS	33303143

Aptamer Sequence:	CCCGAGGCACGAGGGGGAACGTATCGTCATGTGCCGGCCA
The optimal secondary structure in dot-bracket notation:	.....((((((.((.((......)).)).)))))).....
The centroid secondary structure in dot-bracket notation:	.....((((((.((.(........).)).)))))).....

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_960	Description	T-3
Aptamer chemistry	DNA	Length	40 nt
GC content	67.5%	Molecular weight	12,372.93 Da
Molarity of 1 μg/μl solution	80.82 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Aptasensor
Sequence	CCCGAGGCACGAGGGGGAACGTATCGTCATGTGCCGGCCA
Applications	CE-based detection validated the application feasibility of aptamer for Tg detection

Type	Detail	Type	Detail
Uniprot ID	P01266	Protein name	Thyroglobulin (Tg)
Gene name(s)	TG	Organism	Thyroglobulin (Tg)
Status	reviewed in uniprot database	Length	2768
Mass	304,790	Activity regulation	N/A
Involvement in disease	Thyroid dyshormonogenesis 3 (TDH3)	Catalytic activity	N/A
PDB ID(s)	6SCJ;7B75;
Function	Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

No relevant experimental diagram	Interaction ID	1043
	Target type	Protein
	Target unique ID	P01266
	Activity	4.03 μM
	Binding Conditions/Buffer	TGK, Tris-HCl, BBS, and PBS
	Assay	N/A
	PubMed ID	33303143

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_227	DNA	ACGCGCCTATGGTGCATCGCATGCCGACC	57.50%
Apta_722	DNA	CTCTCGGGACGACGGCCCGATCTCAGAGTAGTCGTCCC	57.50%
Apta_591	DNA	CTCTCGGGACGACGGCTGGCACGTTTGGTTCAAGAATGTGGGTGTCGTCCC	56.86%
Apta_728	DNA	CGACCCGGCACAAACCCAGAACCATATACACGATCATTAGTCTCCTGGGCCG	55.77%
Apta_343	DNA	AACAGAGGGACAAACGGGGGAAGATTTGACGTCGACGAC	55.00%
Apta_870	DNA	CCGGGGAATCTAGGGGAGGGCGGGTGGGTCAATTGAGCCG	55.00%
Apta_910	DNA	TCACGTGCATGATAGACGGCGAAGCCGTCGAGTTGCTGTGTGCCGATGCACGTGA	54.55%
Apta_795	DNA	CGCAGCAAGGAGATTCGAGGGGGAAGGTTTGTTATAGGGGTTAATGGA	54.17%
Apta_1047	DNA	TAGTCCCAAGGCACATAAGGGCCGGAGGTCTAGCGTCAGGGATACAGAGA	54.00%
Apta_484	DNA	CAGGGAGGGACAGGGCGGGAATTTGTATGATGGTTCGTTTGCTCG	53.33%
Apta_486	DNA	GGGAGGGATTGGGTGGGCACAGCTCGCTGATAGGTCCTGGTCTCAC	53.19%
Apta_697	DNA	CTCTCGGGACGACGGACGCTAATCTTACAAGGGCGTAGTGTATGTCGTCCC	52.94%
Apta_1127	DNA	TCGGGCGAGTCGTCTGCGAGGCAACAAGCTCGTAATCCGCATCGTCCTCCC	52.94%
Apta_79	DNA	ATCTCGAGTCATAGGGGGCGCGAACATACGCGGTTGGTGTGGTTGGCTGACTCGT	52.73%
Apta_19	DNA	TGAGGGGGGGGGAGGTCGGGCCTGC	52.50%
Apta_150	DNA	CCGTAGGTTCGGGGCGGAGTGGTCCGGAAGGTGGCGTGG	52.50%
Apta_158	DNA	CACAGGCTACGGCACGTAGAGCATCACCATGATCCTGTG	52.50%
Apta_339	DNA	CACAGGCTACGGCACGTAGAGCATCACCATGATCCTGTGT	52.50%
Apta_677	DNA	CCAAATGCGACGGGGCCTGTTTTAATGGGG	52.50%
Apta_678	DNA	CGTACGGTGGGAACGGTTCCTCTTAGGGT	52.50%

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