AptaDB: Result

Interaction ID: 1044

Aptamer sequence: CTAGTGGGGACCTTCCAGGGTAACTGCTCGCATTCTCCAT

Target unique ID: P01266

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_961	T-4	Protein	THYG_HUMAN	7.94 μM	TGK, Tris-HCl, BBS, and PBS	33303143

Aptamer Sequence:	CTAGTGGGGACCTTCCAGGGTAACTGCTCGCATTCTCCAT
The optimal secondary structure in dot-bracket notation:	..(((((..((((....))))..)))))............
The centroid secondary structure in dot-bracket notation:	....((((((.......................)))))).

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_961	Description	T-4
Aptamer chemistry	DNA	Length	40 nt
GC content	55.0%	Molecular weight	12,238.85 Da
Molarity of 1 μg/μl solution	81.71 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Aptasensor
Sequence	CTAGTGGGGACCTTCCAGGGTAACTGCTCGCATTCTCCAT
Applications	CE-based detection validated the application feasibility of aptamer for Tg detection

Type	Detail	Type	Detail
Uniprot ID	P01266	Protein name	Thyroglobulin (Tg)
Gene name(s)	TG	Organism	Thyroglobulin (Tg)
Status	reviewed in uniprot database	Length	2768
Mass	304,790	Activity regulation	N/A
Involvement in disease	Thyroid dyshormonogenesis 3 (TDH3)	Catalytic activity	N/A
PDB ID(s)	6SCJ;7B75;
Function	Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

No relevant experimental diagram	Interaction ID	1044
	Target type	Protein
	Target unique ID	P01266
	Activity	7.94 μM
	Binding Conditions/Buffer	TGK, Tris-HCl, BBS, and PBS
	Assay	N/A
	PubMed ID	33303143

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_1064	DNA	CGATGGAGGACCTCCGGTTTACCGTGTCGTTTTACTCTTG	60.00%
Apta_1192	DNA	CTTTCTGTCCTTCCGTCACATCCCACGCATTCTCCACAT	60.00%
Apta_776	DNA	AGTGGTCGAACTACACATCCTTGAACTGCGGAATTATCTAC	56.10%
Apta_593	DNA	CTCTCGGGACGACAGCCGAGTTGATTCAACAGCCGAGTCGTCCC	54.55%
Apta_391	DNA	ACCGTGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCACGGT	53.33%
Apta_573	DNA	CGTACAGTGGGCTATATTGCTGACGTAAGAGCTGCTTTCAATGCATTGGCATAGATGTCA	53.33%
Apta_1126	DNA	TCGGGCGAGTCGTCTGCGGGCGGATAGACTACGACACCGCATCGTCCTCCC	52.94%
Apta_36	DNA	GTTAATGGGGGATCTCGCGGCCGTTCTTGTTGCTTATACA	52.50%
Apta_193	DNA	AGGAAGGCTTTAGGGTCTGAGATCTCGGAAT	52.50%
Apta_204	DNA	CCAAGGCTTTAGGTCTGAGATCTCCC	52.50%
Apta_205	DNA	TTAAGGCTTTAGGTCTGAGATCTCTT	52.50%
Apta_361	DNA	GGGAACGCCCGTATTGCTCGGTTCCC	52.50%
Apta_363	DNA	ATTGACCGCTGTGTGACGCAACACTCAAT	52.50%
Apta_387	DNA	CTTTAATGCCCTTCACTAGGTCTAAGCTACTACTTACCCG	52.50%
Apta_393	DNA	AGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCT	52.50%
Apta_822	DNA	TAGCCCTTCAACATAGTAATATCTCTGCATTCTGTGATG	52.50%
Apta_877	DNA	GTGCGAAGCGCCTCCACTGTACATCCACTCCTTCTGCC	52.50%
Apta_911	DNA	GGCCATTGTGGACTTCTTTGGGTAATTCAGGGGCTCGATT	52.50%
Apta_985	DNA	CCAGGAGGACCCTATTCTCGTGTATCGACGAGATCCAGTG	52.50%
Apta_1138	DNA	GCAGTGTGGGCGAATCTATGCGTACCGTTCGATATCGTG	52.50%

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