Aptamer-target interaction descriptor
Aptamer-target interaction information
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_46 | C14B1 | Protein | AGR2_HUMAN | 19.1 nM | PBS with 137 mM NACl, 2.7 mM KCl, 10 mM NaHPO4, and 2.0 mM KH2PO4 | 23029506 |
Structure information of aptamer
| Aptamer Sequence: | CGGGTGGGAGTTGTGGGGGGGGGTGGGAGGGTT |
| The optimal secondary structure in dot-bracket notation: | ................................. |
| The centroid secondary structure in dot-bracket notation: | ................................. |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_46 | Description | C14B1 |
| Aptamer chemistry | DNA | Length | 33 nt |
| GC content | 72.7% | Molecular weight | 10,554.72 Da |
| Molarity of 1 μg/μl solution | 94.74 μM | Number of G-quadruplexes | 3 |
| G-Score | 64 | Function | Aptasensor |
| Sequence | CGGGTGGGAGTTGTGGGGGGGGGTGGGAGGGTT | ||
| Applications | Selective and sensitive detection of AGR2 | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Uniprot ID | O95994 | Protein name | Anterior gradient protein 2 homolog (AG-2) (hAG-2) (HPC8) (Secreted cement gland protein XAG-2 homolog) |
| Gene name(s) | AGR2 AG2 UNQ515/PRO1030 | Organism | Anterior gradient protein 2 homolog (AG-2) (hAG-2) (HPC8) (Secreted cement gland protein XAG-2 homolog) |
| Status | reviewed in uniprot database | Length | 175 |
| Mass | 19,979 | Activity regulation | N/A |
| Involvement in disease | N/A | Catalytic activity | N/A |
| PDB ID(s) | 2LNS;2LNT; |
 |
Function | Required for MUC2 post-transcriptional synthesis and secretion. |
Activity data
 |
Interaction ID | 46 |
| Target type | Protein | |
| Target unique ID | O95994 | |
| Activity | 19.1 nM | |
| Binding Conditions/Buffer | PBS with 137 mM NACl, 2.7 mM KCl, 10 mM NaHPO4, and 2.0 mM KH2PO4 |
|
| Assay | The binding constants of C14B1 in the buffer w/ and w/o K+. The data were the average of triplicate experiment results |
|
| PubMed ID | 23029506 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_1193 | DNA | GGGTTGGAGGTGGAGGGGAGTTGAGG | |
| Apta_266 | DNA | TGGATGGTAGCTCGGTCGGGGTGGGTGGGTTGGCAAGTCT | |
| Apta_10 | DNA | GGGGGGGGTGGCTGGGCGGGGTGGG | |
| Apta_679 | DNA | CAGGTGGCAGATCGGGTGTGGGTGGCCTGG | |
| Apta_77 | DNA | GGTGTGGGCGACATGGGGGTTGGTGGTGTAGGAGCGCCAT | |
| Apta_1085 | DNA | TGGGGTGGTGGTGTGGGTGGGGGTTTGTTC | |
| Apta_1194 | DNA | GGGAGAGGTGGGAGCGGGGCCAGGG | |
| Apta_1195 | DNA | GGGGTTGGGGGGAGGCGGGGAATGGGGG | |
| Apta_751 | DNA | GGTCGCAGATGGATTAAGTATGTGGGTGGGGGGGTGGAAGTTAAT | |
| Apta_1188 | DNA | CGGGCGGGGCGTGGGGTGTTGGAGTGGAGGGCGGGGCGGC | |
| Apta_41 | DNA | CGGTCGCTCCGTGTGGCTTGGGTTGGGTGTGGCAGTGAC | |
| Apta_565 | DNA | GCGGGGTTGGGCGGGTGGGTTCGCTGGGCAGGGGGCGAGTG | |
| Apta_590 | DNA | ACCATCTGTGTAAGGGGTAAGGGGTGGGGGTGGGTACGTCT | |
| Apta_942 | DNA | AGTGGGTAAGGTCTGGTGGATTGTGGACGGGGGGCGGGGCAGTGGCTTGA | |
| Apta_1185 | DNA | CAGGGGGTTTTGGTGGGGGGGGCTGGGTTGTCTTGGGGGTGGGCT | |
| Apta_13 | DNA | AGGGGGGGGGGAGGGGTCGGGGTGG | |
| Apta_14 | DNA | AGCGGGGGGGGCTGGGCTGGGTGGG | |
| Apta_17 | DNA | AGGGGGGGGGGTGGGGGTGGGTCCC | |
| Apta_124 | DNA | GGTGGTGGGGGGGGTTGGTAGGGTGTCTTC | |
| Apta_245 | DNA | ACAGGGGTGTGGGGACAGGGGTGTGGGG |
DEV TOOL
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