Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 1035
Aptamer sequence: TCACCTCATACGACTCACTATAGCGGACCCCACTCACTGCTCGGACTCTCCCCCTCCCCGCCTGGCTCGAACAAGCTTGC
Target unique ID: Other-39
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_952 NG51 Other Plasmodium falciparum glutamate dehydrogenase (PfGDH) 1.1 μM N/A 29722521
Structure information of aptamer
Aptamer Sequence: TCACCTCATACGACTCACTATAGCGGACCCCACTCACTGCTCGGACTCTCCCCCTCCCCGCCTGGCTCGAACAAGCTTGC
The optimal secondary structure in dot-bracket notation: .....................(((((..........))))).(((...)))........((..((((......)))).))
The centroid secondary structure in dot-bracket notation: .....................(((((..........)))))..................((..((((......)))).))
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_952 Description NG51
Aptamer chemistry DNA Length 80 nt
GC content 61.3% Molecular weight 24,193.46 Da
Molarity of 1 μg/μl solution 41.33 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Target recognition
Sequence TCACCTCATACGACTCACTATAGCGGACCCCACTCACTGCTCGGACTCTCCCCCTCCCCGCCTGGCTCGAACAAGCTTGC
Applications Detect PfGDH with an LOD of 2.85 nM in diluted serum sample
Target information
Type Detail Type Detail
Target ID Other-39 Name Plasmodium falciparum glutamate dehydrogenase (PfGDH)
Activity data
Interaction ID 1035
Target type Other
Target unique ID Other-39
Activity 1.1 μM
Binding Conditions/Buffer

N/A
Assay

CD measurment data curve fitting for Kd calculation
PubMed ID 29722521
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_953 DNA TCACCTCATACGACTCACTATAGCGGATCCGAGCCGGGGTGTTCTGTTGGCGGGGGCGGTGGGCGGGCTGGCTCGAACAAGCTTGC 70.93%
Apta_951 DNA CACCTAATACGACTCACTATAGCGGATCCGAGGGGGTAGCGGGTGGGCCGGTGGATGCGGGGCGCCGGCGCCTGGCTCGAACAAGCTTGC 68.89%
Apta_950 DNA CACCTAATACGACTCACTATAGCGGATCCGAAGGGGGCGCGAGGTGTAAGGGTGTGGGGTGGTGGGTGGGCCTGGCTCGAACAAGCTTGC 63.33%
Apta_1101 DNA CCGTAATACGACTCACTATAGGTATGTGACGCGCGTCAATCGCTGTCCTACCAAGCTTTGCAGAGAGGATCCTT 56.25%
Apta_1233 DNA TCACGAGAGAGCGAGAGCGCCCCCCCACCACAGCCGTCACCACCCTATTCCTCTGCCGTTG 55.00%
Apta_78 DNA ATCTCGACTAGTCATAGGGGGCGCGAACATACGCGGTTGGTGTGGTTGGCTGACAATACTCGT 52.50%
Apta_405 DNA TCTAGCCCACTGCATAGAGGTAGCCACGTATGTGGGTGTTACCCATTCGTAGCTACCGGTG 52.50%
Apta_448 DNA TAACTCACTCCATACTCACTTGCTGATTCGCCAACAACACACCCTTAAACAGTCCC 52.50%
Apta_665 DNA CGCCAATCTCAAAGCCCGCCACCTGCCCCTCACTGCCCACCTGTGGAATCCATGTCGCTC 52.50%
Apta_1266 DNA GCATCACACACCGATACTCACCCGCCTGATTAACATTAGCCCACCGCCCACCCCCGCTGC 52.50%
Apta_281 DNA CCGTAATACGACTCACTATAGGGGAGCTCGGTACCGAATTCATGTTGGTAGTTGGCTTGTGTTCGTGTGTTAAGCTTTCAGAGAGGATCCTT 52.17%
Apta_804 DNA GCGGGATCCTATGACGCATTGACCCACAACACACTACTGTCGCTCGGTTCGAACTTCGTGCGACTGTTCCCTATAGTGAGTCGTATTAGAATTCCGC 51.55%
Apta_663 DNA CACGCACAGAAGACACCTACAGGGCCAGATCACAATCGGTTAGTGAACTCGTACGGCGCG 51.25%
Apta_689 DNA CCACACAACAGCCTACGTGGATACACCACATACATCCCATAACCCCGTGTCATGTGTCG 51.25%
Apta_698 DNA AGCAGCACAGAGGTCAGATGCACTCGGACCCCATTCTCCTTCCATCCCTCATCCGTCCACCCTATGCGTGCTACCGTGAA 51.25%
Apta_810 DNA ACAGCATCCCCATGTGAACAATCGCATTGTGATTGTTACGGTTTCCGCCTCATGGACGTGCTG 51.25%
Apta_1113 DNA CCGCCCAAATCCCTAAGAGCACAAACACCAAACACAACCACCCCAACCAGACACACTACACACGCA 51.25%
Apta_1264 DNA CAACGATCGTACCACAGTACCCACCCACCAGCCCCAACATCATGCCCATGCGTCGGTGTG 51.25%
Apta_550 DNA GGTAATACGACTCACTATAGGGAGATACCAGCTTATTCAATTTTACAGAACAACCAACGTCGCTCCGGGTACTTCTTCATCGAGATAGTAAGTGCAATCT 51.00%
Apta_628 DNA ATACCAGCTTATTCAATTAGCCCGGTATTGAGGTCGATCTCTTATCCTATGGCTTGTCCCCCATGGCTCGGTTATATCCAGATAGTAAGTGCAATCT 50.52%

ABOUT

AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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