Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 650
Aptamer sequence: AATCGCATTACCTTATACCAGCTTATTCAATTACGTCTGCACATACCAGCTTATTCAATT
Target unique ID: 2733487
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_614 FB1 39 Molecule Fumonisin b1 100 nM 100 mM NaCl, 20 mM Tris, 2 mM MgCl2, 5 mM KCl, 1 mM CaCl2, pH 7.6 incubate with target for 60 minutes 21614178
Structure information of aptamer
Aptamer Sequence: AATCGCATTACCTTATACCAGCTTATTCAATTACGTCTGCACATACCAGCTTATTCAATT
The optimal secondary structure in dot-bracket notation: ......................................((........))..........
The centroid secondary structure in dot-bracket notation: ............................................................
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_614 Description FB1 39
Aptamer chemistry DNA Length 60 nt
GC content 35.0% Molecular weight 18,236.76 Da
Molarity of 1 μg/μl solution 54.83 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Targeted binding
Sequence AATCGCATTACCTTATACCAGCTTATTCAATTACGTCTGCACATACCAGCTTATTCAATT
Applications Binding to fumonisin B1
Target information
Type Detail Type Detail
PubChem ID 2733487 Molecular name Fumonisin b1
Molecular formula C34H59NO15 Molecular weight 721.8
IUPAC name (2R)-2-[2-[(5R,6R,7S,9S,11R,16R,18S,19S)-19-amino-6-[(3R)-3,4-dicarboxybutanoyl]oxy-11,16,18-trihydroxy-5,9-dimethylicosan-7-yl]oxy-2-oxoethyl]butanedioic acid InChIKey UVBUBMSSQKOIBE-DSLOAKGESA-N
LogP 2.564 Topological polar surface area 288.51
Hydrogen bond acceptor 12 Hydrogen bond donor 8

Synonym(s):
fumonisin b1; fumonisin-B1; 116355-83-0; Macrofusine; UNII-3ZZM97XZ32; 3ZZM97XZ32; 1,2,3-Propanetricarboxylic acid, 1,1'-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl] ester, (2R,2'R)-; fumonisin B(1); Q63395324; (R)-3-Carboxy-pentanedioic acid mono-{(1S,3S,5R,10R,12S,13S)-13-amino-1-[(1R,2R)-1-((R)-3,4-dicarboxy-butyryloxy)-2-methyl-hexyl]-5,10,12-trihydroxy-3-methyl-tetradecyl} ester; Fumonisin B1 50 microg/mL in Acetonitrile/Water; FB1; CCRIS 4433; HSDB 7077; (2R)-2-[2-[(5R,6R,7S,9S,11R,16R,18S,19S)-19-amino-6-[(3R)-3,4-dicarboxybutanoyl]oxy-11,16,18-trihydroxy-5,9-dimethylicosan-7-yl]oxy-2-oxoethyl]butanedioic acid; NSC 629151; (2R,2'R)-2,2'-{[(5R,6R,7S,9S,11R,16R,18S,19S)-19-amino-11,16,18-trihydroxy-5,9-dimethylicosane-6,7-diyl]bis[oxy(2-oxoethane-2,1-diyl)]}dibutanedioic acid; SCHEMBL13555629; CHEBI:38221; Fumonisin B1, reference material; HY-N6719; ZINC4262459; LMSP01080022; AKOS024457430; 1,2,3-Propanetricarboxylic acid, 1,1'-(1-(12-amino-4,9,11-trihydroxy-2-methyltridecyl)-2-(1-methylpentyl)-1,2-ethanediyl) ester; CS-0029116; Fumonisin B1 from Fusarium moniliforme, >=98% (HPLC); Fumonisin B1 solution, 50 mug/mL in acetonitrile: water, analytical standard; 1,1'-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-Amino-4,9,11-trihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl-1,2,3-(2R,2'R)-propanetricarboxylic acid ester.; 1,2,3-Propanetricarboxylic acid, 1,1'-(1-(12-amino-4,9,11-trihydroxy-2-methyltridecyl)-2-(1-methylpentyl)-1,2-ethanediyl)ester

Activity data
Interaction ID 650
Target type Molecule
Target unique ID 2733487
Activity 100 nM
Binding Conditions/Buffer

100 mM NaCl, 20 mM Tris, 2 mM MgCl2, 5 mM KCl, 1 mM CaCl2, pH 7.6 incubate with target for 60 minutes
Assay

Binding curves for the aptamer sequence FB1 39
PubMed ID 21614178
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_349 DNA ATACCAGCTTATTCAATTAGACGAGTTTTATTCATTTTCCATGTCGTAGCTTACCGTGAGATAGTAAGTGCAATCT 59.21%
Apta_884 DNA ATACCAGCTTATTCAATTTGCACCACTTATTGTTACTAATCTGAGATAGTAAGTGCAATCT 55.74%
Apta_448 DNA TAACTCACTCCATACTCACTTGCTGATTCGCCAACAACACACCCTTAAACAGTCCC 55.00%
Apta_532 DNA ATCCGTCACACCTGCTCTAACTTACACATAATTCTAGGTTACATCTTGCTCATATGGTGTTGGCTCCCGTAT 54.17%
Apta_792 DNA ATACCAGCTTATTCAATTCCCAAATTGCCACCACTTACAGCATGATAACATACTACATCTTTTCATCAAGATAGTAAGTGCAATCT 53.49%
Apta_139 DNA GATAAACGCCTTGATTAAAGGCCCAGTTCTTTAGGCCTACACGTGCTGCGACATTAATT 53.33%
Apta_238 DNA CACACATTCCCGTCCTCGATACGTCTAGGCTTAGTGCCACTTGCTTAATC 53.33%
Apta_395 DNA AATCCACGTATCGACTAGCTCAAACCAGCCTGATAGAGCCATTCGCTTTA 53.33%
Apta_1119 DNA GGGAATGGATCCACATCTACGAATTCGGTTGTGAAGATTGGGAGCGTCGTGGCTACTTCACTGCAGACTTGACGAAGCTT 52.50%
Apta_1015 DNA ATACCAGCTTATTCAATTGACCCGTTTCGTTCCCTCTGGGAAGTTTAGCCCAGTTGCCTGGGCGATACCAAGATAGTAAGTGCAATCT 52.27%
Apta_355 DNA GATGCAGCCACCTACATTGCAGGTTTTATAATACAACTACGCGCCGTTCGCAGGCTAGTT 51.67%
Apta_510 DNA TGTAATTTGTCTGCAGCGGTTCTTGATCGCTGACACCATATTATGAAGA 51.67%
Apta_604 DNA TCCTGACCTTAGCCTATGTTTTCTCTACCGGCTATGTTAC 51.67%
Apta_644 DNA TCAATCTAACCATGCATGCAGTTTAGGCAGGATTCGTTATCGCAA 51.67%
Apta_977 DNA CAATCTGCTAAAACTTAAAGCCTATTAATGAAATTGTTAAGGTGGTATCC 51.67%
Apta_980 DNA AACGAGCACGCTTTGTGTACAGCCACTAAATAAGGTATGTAGTCAGCACCCTCGTAAC 51.67%
Apta_1063 DNA AACTTATCGGAGCGTGATTTCCGTCTCGCCGCTTTCCTTT 51.67%
Apta_1000 DNA ATAGGAGTCGACCGACCAGAACCGTTCCCATACTTCTCCAGCGATACTTAGTGCGTCTACATCTAGACTC 51.43%
Apta_511 DNA ATCCGTCACACCTGCTCTCAGGGGATCACATTCTTGACGGTGTGATACAGTGCCTGGTGTTGGCTCCCGTAT 51.39%
Apta_899 DNA ATCCGTCACACCTGCTCTCGAATAGAGTATTCGATACTGACTTTATTTACCGTCTGGTGTTGGCTCCCGTAT 51.39%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
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