AptaDB: Result

Interaction ID: 1214

Aptamer sequence: TTAATTTTTTGATCTTTGATTGTTTTATTTTTTTTATTGTTTGTG

Target unique ID: P03524

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_1154	GE58	Protein	GLYCO_RABVE	475 nM	4.5 g/l glucose and 5 mmol/l MgCl2 in Dulbecco’s PBS	24486485

Aptamer Sequence:	TTAATTTTTTGATCTTTGATTGTTTTATTTTTTTTATTGTTTGTG
The optimal secondary structure in dot-bracket notation:	.............................................
The centroid secondary structure in dot-bracket notation:	.............................................

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_1154	Description	GE58
Aptamer chemistry	DNA	Length	45 nt
GC content	15.6%	Molecular weight	13,815.88 Da
Molarity of 1 μg/μl solution	72.38 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted therapy
Sequence	TTAATTTTTTGATCTTTGATTGTTTTATTTTTTTTATTGTTTGTG
Applications	Inhibit the replication of RABV

Type	Detail	Type	Detail
Uniprot ID	P03524	Protein name	Glycoprotein
Gene name(s)	G	Organism	Glycoprotein
Status	reviewed in uniprot database	Length	524
Mass	58,658	Activity regulation	N/A
Involvement in disease	N/A	Catalytic activity	N/A
PDB ID(s)	3NFK;
Function	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane.

	Interaction ID	1214
	Target type	Protein
	Target unique ID	P03524
	Activity	475 nM
	Binding Conditions/Buffer	4.5 g/l glucose and 5 mmol/l MgCl2 in Dulbecco’s PBS
	Assay	The inhibition of non-RABV viral infections by aptamers in vitro
	PubMed ID	24486485

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_1155	DNA	TAGTTTTATTTGTTCATTTTGTGTATTGTTTTGA	62.22%
Apta_1280	DNA	TCATATCCTTCTTGGTATCATTGCGTCATTTAGTCATTCATGTTATTCCCGAGGG	56.36%
Apta_216	DNA	TGGTTGGTTTTTGGTTTTTTTTTTTGGTTT	55.56%
Apta_285	DNA	GCCACTCCGTCACTTTAGTGGTTTTTTTTATAAATGCTTC	55.56%
Apta_851	DNA	CCATGTTTTGTAGGTGTAATAGGTCATGTTAGGGTTTCTG	53.33%
Apta_1238	DNA	GGTTTTGTGTTTGTGTTTTGTGGTTGTTGT	53.33%
Apta_357	DNA	ACAATGTCGCTCTCCGCCGCAGGAGCATTGTCTGTCTTTATGCTTCTCTTTTTTGTTGC	52.54%
Apta_882	DNA	AATAGTCTGGTTCGGTGCTTGGTGCGATGTGTTAGTCAGACTCTTGTGTG	52.00%
Apta_970	DNA	TTATGTAGCATTTATGAAATTTTTAAATCAATTTACTATTGGTGGTATCC	52.00%
Apta_482	DNA	AGCAAGGTTTGGTGTTGGTTGGTTGCTGGTTTTGGTTTC	51.11%
Apta_913	DNA	GGCACTTGTTTGCTCGAACGATGGTTTGTGCTTTTGTGTT	51.11%
Apta_1153	DNA	TATTTTTATATTTGTTTGACAGTCGCTTGCTTGTGTAGGCGTT	51.11%
Apta_1236	DNA	GGACTGTTGTGGTATTATTTTTGGTTGTGC	51.11%
Apta_223	DNA	CATTGAGATAGCTAGTTGTAGCTGCGTCATAGGCTGGGTTGGGTCTAGTGGTTGGGTGTG	50.00%
Apta_317	DNA	GGTTGGTGTGGTTGGTTTTTTTTTTTTTTTTTTTTAGTCCGTGGTAGGGCAGGTTGGGGTGACT	50.00%
Apta_1281	DNA	CACACCTTGACTTTCTTCTTTTTGAAGTTGAACCTGTTGTACTAGTGTTACCCCTAGGG	49.15%
Apta_510	DNA	TGTAATTTGTCTGCAGCGGTTCTTGATCGCTGACACCATATTATGAAGA	48.98%
Apta_58	DNA	GCACCTTGATGACATGATAGTCGTTGTGTATGCAGTTGGC	48.89%
Apta_407	DNA	GTGAATTGCGTTGAATTATGTTTTTTCAGTCATCACT	48.89%
Apta_564	DNA	GGGGACTGTTGTGGTATTATTTTTGGTTGTGCAGT	48.89%

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