Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 420
Aptamer sequence: GGGAGGACGAUGCGGCCGAUUAGAACUGGGCUGAGGCGUUCUGCAUUUCGGUGAUCAGACGACUCGCUGAGGAUCCGAGA
Target unique ID: P68871
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_414 DE3A Protein HBB_HUMAN 1.67 μM 20 mM HEPES pH 7.4, 150 mM NaCl, 2 mM CaCl2, 0.01% BSA 29039727
Structure information of aptamer
Aptamer Sequence: GGGAGGACGAUGCGGCCGAUUAGAACUGGGCUGAGGCGUUCUGCAUUUCGGUGAUCAGACGACUCGCUGAGGAUCCGAGA
The optimal secondary structure in dot-bracket notation: ...((((((...(((((...........)))))...))))))...((((((...((((.((...))))))....))))))
The centroid secondary structure in dot-bracket notation: ...((((((...(((((...........)))))...))))))...((((((...((((.((...))))))....))))))
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_414 Description DE3A
Aptamer chemistry RNA Length 80 nt
GC content 58.8% Molecular weight 25,977.44 Da
Molarity of 1 μg/μl solution 38.49 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Targeted therapy
Sequence GGGAGGACGAUGCGGCCGAUUAGAACUGGGCUGAGGCGUUCUGCAUUUCGGUGAUCAGACGACUCGCUGAGGAUCCGAGA
Applications Bind hemoglobin, significantly increase the delay time, and reduce the rate of polymerization of HbS
Target information
Type Detail Type Detail
Uniprot ID P68871 Protein name Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin]
Gene name(s) HBB Organism Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin]
Status reviewed in uniprot database Length 147
Mass 15,998 Activity regulation N/A
Involvement in disease Heinz body anemias (HEIBAN) Catalytic activity N/A
PDB ID(s)
1A00;1A01;1A0U;1A0Z;1A3N;1A3O;1ABW;1ABY;1AJ9;1B86;1BAB;1BBB;1BIJ;1BUW;1BZ0;1BZ1;1BZZ;1C7B;1C7C;1C7D;1CBL;1CBM;1CH4;1CLS;1CMY;1COH;1DKE;1DXT;1DXU;1DXV;1FN3;1G9V;1GBU;1GBV;1GLI;1GZX;1HAB;1HAC;1HBA;1HBB;1HBS;1HCO;1HDB;1HGA;1HGB;1HGC;1HHO;1IRD;1J3Y;1J3Z;1J40;1J41;1J7S;1J7W;1J7Y;1JY7;1K0Y;1K1K;1KD2;1LFL;1LFQ;1LFT;1LFV;1LFY;1LFZ;1LJW;1M9P;1MKO;1NEJ;1NIH;1NQP;1O1I;1O1J;1O1K;1O1L;1O1M;1O1N;1O1O;1O1P;1QI8;1QSH;1QSI;1QXD;1QXE;1R1X;1R1Y;1RPS;1RQ3;1RQ4;1RQA;1RVW;1SDK;1SDL;1THB;1UIW;1VWT;1XXT;1XY0;1XYE;1XZ2;1XZ4;1XZ5;1XZ7;1XZU;1XZV;1Y09;1Y0A;1Y0C;1Y0D;1Y0T;1Y0W;1Y22;1Y2Z;1Y31;1Y35;1Y45;1Y46;1Y4B;1Y4F;1Y4G;1Y4P;1Y4Q;1Y4R;1Y4V;1Y5F;1Y5J;1Y5K;1Y7C;1Y7D;1Y7G;1Y7Z;1Y83;1Y85;1Y8W;1YDZ;1YE0;1YE1;1YE2;1YEN;1YEO;1YEQ;1YEU;1YEV;1YFF;1YG5;1YGD;1YGF;1YH9;1YHE;1YHR;1YIE;1YIH;1YVQ;1YVT;1YZI;2D5Z;2D60;2DN1;2DN2;2DN3;2DXM;2H35;2HBC;2HBD;2HBE;2HBF;2HBS;2HCO;2HHB;2HHD;2HHE;2M6Z;2W6V;2W72;2YRS;3B75;3D17;3D7O;3DUT;3HHB;3HXN;3IC0;3IC2;3KMF;3NL7;3NMM;3ODQ;3ONZ;3OO4;3OO5;3P5Q;3QJB;3QJC;3QJD;3QJE;3R5I;3S65;3S66;3SZK;3W4U;3WCP;3WHM;4FC3;4HHB;4IJ2;4L7Y;4M4A;4M4B;4MQC;4MQG;4MQH;4MQI;4N7N;4N7O;4N7P;4N8T;4NI0;4NI1;4ROL;4ROM;4WJG;4X0L;4XS0;5E29;5E6E;5E83;5EE4;5HU6;5HY8;5JDO;5KDQ;5KSI;5KSJ;5NI1;5SW7;5U3I;5UCU;5UFJ;5URC;5VMM;5WOG;5WOH;5X2R;5X2S;5X2T;5X2U;6BB5;6BNR;6BWP;6BWU;6DI4;6FQF;6HAL;6HBW;6HK2;6KA9;6KAE;6KAH;6KAI;6KAO;6KAP;6KAQ;6KAR;6KAS;6KAT;6KAU;6KAV;6KYE;6L5V;6L5W;6L5X;6L5Y;6LCW;6LCX;6NBC;6NBD;6NQ5;6TB2;6XD9;6XDT;6XE7;7AET;7AEU;7AEV;7CUE;7DY3;7DY4;7JJQ;7JXZ;7JY0;7JY1;7JY3;7PCF;7PCH;7PCQ;7UD7;7UD8;7UF6;7UF7;7VDE;
Function Involved in oxygen transport from the lung to the various peripheral tissues.
Activity data
Interaction ID 420
Target type Protein
Target unique ID P68871
Activity 1.67 μM
Binding Conditions/Buffer

20 mM HEPES pH 7.4, 150 mM NaCl, 2 mM CaCl2, 0.01% BSA
Assay

Saturation binding curves for individual aptamers
PubMed ID 29039727
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_398 RNA GGGAGGACGAUGCGGCUUUAAUCCUCGCACUCAGCGCGCAUCACCCUUGACAUCACAGACGACUCGCUGAGGAUCCGAGA 72.50%
Apta_399 RNA GGGAGGACGAUGCGGCAAACCAGCUAUUUCCUGAGGUACCCCGGCUCUCCAUGGCAGACGACUCGCUGAGGAUCCGAGA 72.50%
Apta_400 RNA GGGAGGACGAUGCGGAUACCAGCGAAUAACUCGCUGAGGAACCCGACUCACAAACAGACGACUCGCUGAGGAUCCGAGA 71.25%
Apta_396 RNA GGGAGGACGAUGCGGCAGUCUGCAUCGUAGGAAUCGCCACCGUAUACUUUCCCACCAGACGACUCGCUGAGGAUCCGAGA 70.00%
Apta_415 RNA GGGAGGACGAUGCGGAAACUCAUCGGUAGCCUUCCUGCGGUCAGUCUAUUAGGACCAGACGACUCGCUGAGGAUCCGAGA 70.00%
Apta_467 RNA GGGAGGACGAUGCGGCAGUGCCCAACCGGAACAACAACCACCGGCGGCUCCUGCUCAGACGACUCGCUGAGGAUCCGAGA 70.00%
Apta_397 RNA GGGAGGACGAUGCGGAUACCAGGAUCACAUCCUGAGGAACCCCGGCUCCCAACCUCAGACGACUCGCUGAGGAUCCGAGA 67.50%
Apta_130 RNA GGGAGGACGAUGCGGUGGUAGCGCGAUAUAGCGCUGGUAGGGUUGCCGGUGAUCAGACGACUCGCCCGA 63.75%
Apta_984 RNA GGGAGGACGAUGCGGCGUAUUGCGCGAGGAUUAUCCGCUCAUCGUUGUUGUUGUGCAGACGACUCGCCCGA 63.75%
Apta_352 RNA GGGAGGACGAUGCGGUGGUCUCCCAAUUCUAAACUUUCUCCAUCGUAUCUGGGCAGACGACUCGCCCGA 60.00%
Apta_131 RNA GGGAGGACGAUGCGGUCCUGUCGUCUGUUCGUCCCCAGACGACUCGCCCGA 58.75%
Apta_132 RNA GGGAGGACGAUGCGGCGUUUCCUCUGGUUCGUCCCCAGACGACUCGCCCGA 58.75%
Apta_133 RNA GGGAGGACGAUGCGGUGAGUCGUUCCCUUCGUCCCCAGACGACUCGCCCGA 58.75%
Apta_315 RNA GGGAGGACGAUGCGGUCGUAUUAUCCGCUGCACGCCAGACGACUCGCCCGA 58.75%
Apta_129 RNA GGGAGGACGAUGCGGACACCGUUAAUCUGAGGCCCUGUCCUAUUCCUUCACGCCUCAGA 57.50%
Apta_134 RNA GGGAGGACGAUGCGGGCCGUUGUUGUGUGCCGCCCCAGACGACUCGCCCGA 57.50%
Apta_135 RNA GGGAGGACGAUGCGGAUUCUGGUUACUGGCCGCCCCAGACGACUCGCCCGA 57.50%
Apta_305 RNA GGGAGGACGAUGCGGAUCGCCCUGAACCGGCCCAGCAGACUGCUGACGGCACGAUCCGCAUCGUCCUCCC 57.50%
Apta_137 RNA GGGAGACAAGAAUAAACGCUCAAGUGACGUCCUGAUCGAUUGUGCAUUCGGUGUGACGAUCUUUCGACAGGAGGCUCACAACAGGC 56.98%
Apta_574 RNA AUGAAAAGGGCUGGCGAGACAUAUCCGCUGGGCAAUCAGAUUCGGAGCCGCACCACCCUCGAAGUAGACA 55.00%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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