AptaDB: Result

Interaction ID: 397

Aptamer sequence: ACCGTGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCACGGT

Target unique ID: P40259

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_391	TD05	Protein	CD79B_HUMAN	359 nM	RPMI 1640, 4.5 g/L glucose, 5 mM MgCl2 in vivo (20 mM MgCl2 in vitro), 100 mg/L tRNA and 100 mg/L BSA	21030439

Aptamer Sequence:	ACCGTGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCACGGT
The optimal secondary structure in dot-bracket notation:	(((((((((((.........((((......)))))))))))))))
The centroid secondary structure in dot-bracket notation:	(((((((((((.........((((......)))))))))))))))

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_391	Description	TD05
Aptamer chemistry	DNA	Length	45 nt
GC content	60.0%	Molecular weight	13,915.89 Da
Molarity of 1 μg/μl solution	71.86 μM	Number of G-quadruplexes	2
G-Score	17	Function	Targeted binding
Sequence	ACCGTGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCACGGT
Applications	Improved kinetic and biochemical features, unique specificity and desirable pharmacological properties, may be useful in biomedical applications

Type	Detail	Type	Detail
Uniprot ID	P40259	Protein name	B-cell antigen receptor complex-associated protein beta chain (B-cell-specific glycoprotein B29) (Ig-beta) (Immunoglobulin-associated B29 protein) (CD antigen CD79b)
Gene name(s)	CD79B B29 IGB	Organism	B-cell antigen receptor complex-associated protein beta chain (B-cell-specific glycoprotein B29) (Ig-beta) (Immunoglobulin-associated B29 protein) (CD antigen CD79b)
Status	reviewed in uniprot database	Length	229
Mass	26,048	Activity regulation	N/A
Involvement in disease	Agammaglobulinemia 6, autosomal recessive (AGM6)	Catalytic activity	N/A
PDB ID(s)	3KG5;
Function	Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation.

No relevant experimental diagram	Interaction ID	397
	Target type	Protein
	Target unique ID	P40259
	Activity	359 nM
	Binding Conditions/Buffer	RPMI 1640, 4.5 g/L glucose, 5 mM MgCl2 in vivo (20 mM MgCl2 in vitro), 100 mg/L tRNA and 100 mg/L BSA
	Assay	N/A
	PubMed ID	21030439

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_729	DNA	AACACCGTGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCCGGTG	89.58%
Apta_393	DNA	AGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCT	82.22%
Apta_392	DNA	GGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCT	73.33%
Apta_915	DNA	ACTTCGGCTAGTTAGGGGGTAGTTTAGATCGTCTCTACAT	60.00%
Apta_585	DNA	GATCGAGGGCAGCGATAGCTGGGCTAATAAGGTTAGCCCCATCGGTC	59.57%
Apta_910	DNA	TCACGTGCATGATAGACGGCGAAGCCGTCGAGTTGCTGTGTGCCGATGCACGTGA	58.18%
Apta_181	DNA	CCGTGTAAGGTTTCAGTGGCTTATCCGAAGTAACCCGAGA	57.78%
Apta_1176	DNA	AGTATGATATCGGTGTTTATGGTGTCTGTCTTCATACT	57.78%
Apta_571	DNA	ACCTGCGATAGGTAGTTTGTTTCTGTTGCCCTAGCGTCCGTCGTAACAAGTCA	56.60%
Apta_1277	DNA	TCCGTGGTACGGTTACTCGTTCCTTATGTATGTTGCTACAATGGATTGCGTCCCCAGGG	55.93%
Apta_1229	DNA	CACGGGCAGAGGGATAGGTTGTTGACGGGGCTGGTGGGTGGGTGCGCTCGCGCTATCGTGG	55.74%
Apta_73	DNA	GGGGAGTAGGTTGGTGTGGTTGGGGCTCCCC	55.56%
Apta_185	DNA	ACCAAGGCTTTAGGTCTGAGATCTCCCAAT	55.56%
Apta_341	DNA	TCGGGGTTTGGGGGTTCGGGGTCGGTTCGGTTTCTTCTAATGGA	55.56%
Apta_552	DNA	CACCTGGGGGAGTATTGCGGAGGAAGGTTCCAGGTG	55.56%
Apta_746	DNA	AGAGTGGGGGGGTGGGTGGATTTGACAGGTGGCATGCTGGAGAGT	55.56%
Apta_1093	DNA	AGGAGGGTAGGTAGTGCTTGGTAGGGAAACTCCGCCGATT	55.56%
Apta_1276	DNA	TCAATGGGATGTTAGTATGCAAAGATATTCTGTTCAGTGTGTGCCCAGGCCCCCAGGG	55.17%
Apta_1018	DNA	ATCCCTGCAGTTTGGTAGGGTGCGAGCAACATCAGGCACCTGCAGG	54.35%
Apta_1046	DNA	TCGCATGGAGGGCAGAGCCGCCTGCCGGGATCCGGCCCTCTTGGGCGGGC	54.00%

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