Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 404
Aptamer sequence: GGGAGGACGAUGCGGCUUUAAUCCUCGCACUCAGCGCGCAUCACCCUUGACAUCACAGACGACUCGCUGAGGAUCCGAGA
Target unique ID: P47741
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_398 aptamer 11.4 Protein TNR4_MOUSE 25 nM 150 mM NaCl, 2 mM CaCl2, and 20 mM Hepes (pH 7.4) 18635004
Structure information of aptamer
Aptamer Sequence: GGGAGGACGAUGCGGCUUUAAUCCUCGCACUCAGCGCGCAUCACCCUUGACAUCACAGACGACUCGCUGAGGAUCCGAGA
The optimal secondary structure in dot-bracket notation: ..((((..(((((((((...............))).))))))..))))...(((.(((.((...)))))..)))......
The centroid secondary structure in dot-bracket notation: ..((((..(((((((((...............))).))))))..))))...(((.(((.((...)))))..)))......
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_398 Description aptamer 11.4
Aptamer chemistry RNA Length 80 nt
GC content 58.8% Molecular weight 25,703.33 Da
Molarity of 1 μg/μl solution 38.91 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Targeted binding
Sequence GGGAGGACGAUGCGGCUUUAAUCCUCGCACUCAGCGCGCAUCACCCUUGACAUCACAGACGACUCGCUGAGGAUCCGAGA
Applications The OX40 receptor-activating aptamer is able to induce nuclear localization of NFκB, cytokine production and cell proliferation as well as enhance the potency of dendritic cell-based tumor vaccines when systemically delivered to mice
Target information
Type Detail Type Detail
Uniprot ID P47741 Protein name Tumor necrosis factor receptor superfamily member 4 (OX40 antigen) (OX40L receptor) (CD antigen CD134)
Gene name(s) Tnfrsf4 Ox40 Txgp1 Organism Tumor necrosis factor receptor superfamily member 4 (OX40 antigen) (OX40L receptor) (CD antigen CD134)
Status reviewed in uniprot database Length 272
Mass 30,154 Activity regulation N/A
Involvement in disease N/A Catalytic activity N/A
PDB ID(s)
N/A
Function Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
Activity data

No relevant experimental diagram

 Interaction ID 404
Target type Protein
Target unique ID P47741
Activity 25 nM
Binding Conditions/Buffer

150 mM NaCl, 2 mM CaCl2, and 20 mM Hepes (pH 7.4)
Assay

N/A
PubMed ID 18635004
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_396 RNA GGGAGGACGAUGCGGCAGUCUGCAUCGUAGGAAUCGCCACCGUAUACUUUCCCACCAGACGACUCGCUGAGGAUCCGAGA 73.75%
Apta_400 RNA GGGAGGACGAUGCGGAUACCAGCGAAUAACUCGCUGAGGAACCCGACUCACAAACAGACGACUCGCUGAGGAUCCGAGA 72.50%
Apta_414 RNA GGGAGGACGAUGCGGCCGAUUAGAACUGGGCUGAGGCGUUCUGCAUUUCGGUGAUCAGACGACUCGCUGAGGAUCCGAGA 72.50%
Apta_399 RNA GGGAGGACGAUGCGGCAAACCAGCUAUUUCCUGAGGUACCCCGGCUCUCCAUGGCAGACGACUCGCUGAGGAUCCGAGA 71.25%
Apta_415 RNA GGGAGGACGAUGCGGAAACUCAUCGGUAGCCUUCCUGCGGUCAGUCUAUUAGGACCAGACGACUCGCUGAGGAUCCGAGA 71.25%
Apta_397 RNA GGGAGGACGAUGCGGAUACCAGGAUCACAUCCUGAGGAACCCCGGCUCCCAACCUCAGACGACUCGCUGAGGAUCCGAGA 70.00%
Apta_467 RNA GGGAGGACGAUGCGGCAGUGCCCAACCGGAACAACAACCACCGGCGGCUCCUGCUCAGACGACUCGCUGAGGAUCCGAGA 68.75%
Apta_984 RNA GGGAGGACGAUGCGGCGUAUUGCGCGAGGAUUAUCCGCUCAUCGUUGUUGUUGUGCAGACGACUCGCCCGA 61.25%
Apta_130 RNA GGGAGGACGAUGCGGUGGUAGCGCGAUAUAGCGCUGGUAGGGUUGCCGGUGAUCAGACGACUCGCCCGA 60.00%
Apta_305 RNA GGGAGGACGAUGCGGAUCGCCCUGAACCGGCCCAGCAGACUGCUGACGGCACGAUCCGCAUCGUCCUCCC 60.00%
Apta_132 RNA GGGAGGACGAUGCGGCGUUUCCUCUGGUUCGUCCCCAGACGACUCGCCCGA 58.75%
Apta_723 RNA GGGAGCUCAGAAUAAACGCUCAAAUCCGUGGACAGGGCGUAAGCGCCUUCGACAUGAGACACGGAUCCUGCGACGAAUUCAGC 57.83%
Apta_315 RNA GGGAGGACGAUGCGGUCGUAUUAUCCGCUGCACGCCAGACGACUCGCCCGA 57.50%
Apta_352 RNA GGGAGGACGAUGCGGUGGUCUCCCAAUUCUAAACUUUCUCCAUCGUAUCUGGGCAGACGACUCGCCCGA 57.50%
Apta_131 RNA GGGAGGACGAUGCGGUCCUGUCGUCUGUUCGUCCCCAGACGACUCGCCCGA 56.25%
Apta_133 RNA GGGAGGACGAUGCGGUGAGUCGUUCCCUUCGUCCCCAGACGACUCGCCCGA 56.25%
Apta_135 RNA GGGAGGACGAUGCGGAUUCUGGUUACUGGCCGCCCCAGACGACUCGCCCGA 56.25%
Apta_39 RNA GGUAGAUACGAUGGACUACCGCCACCCCGGGUCCGGGUGACGUUAAUUGAGGGCCCAUGACGCGCAGCCA 53.75%
Apta_129 RNA GGGAGGACGAUGCGGACACCGUUAAUCUGAGGCCCUGUCCUAUUCCUUCACGCCUCAGA 53.75%
Apta_134 RNA GGGAGGACGAUGCGGGCCGUUGUUGUGUGCCGCCCCAGACGACUCGCCCGA 53.75%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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