AptaDB: Result

Interaction ID: 371

Aptamer sequence: GGUUAGAGGCGACGUCCCGGAAUCCGCGCCCAUUGCCCCC

Target unique ID: P23284

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_366	M9-4	Protein	PPIB_HUMAN	N/A	20 mM HEPES pH 7.5, 150 mM NaCl, 2mM CaCl2, and 3 mM MgCl2	22484812

Aptamer Sequence:	GGUUAGAGGCGACGUCCCGGAAUCCGCGCCCAUUGCCCCC
The optimal secondary structure in dot-bracket notation:	(((....((((.((..........))))))....)))...
The centroid secondary structure in dot-bracket notation:	(((....((((.((..........))))))....)))...

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_366	Description	M9-4
Aptamer chemistry	RNA	Length	40 nt
GC content	70.0%	Molecular weight	13,015.58 Da
Molarity of 1 μg/μl solution	76.83 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted therapy
Sequence	GGUUAGAGGCGACGUCCCGGAAUCCGCGCCCAUUGCCCCC
Applications	Discriminated between the sera of pancreatic cancer patients and healthy volunteers with high sensitivity and specificity

Type	Detail	Type	Detail
Uniprot ID	P23284	Protein name	Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)
Gene name(s)	PPIB CYPB	Organism	Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)
Status	reviewed in uniprot database	Length	216
Mass	23,743	Activity regulation	Inhibited by cyclosporin A (CsA)
Involvement in disease	Osteogenesis imperfecta 9 (OI9)	Catalytic activity	Reaction=[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)
PDB ID(s)	1CYN;3ICH;3ICI;
Function	PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.

No relevant experimental diagram	Interaction ID	371
	Target type	Protein
	Target unique ID	P23284
	Activity	N/A
	Binding Conditions/Buffer	20 mM HEPES pH 7.5, 150 mM NaCl, 2mM CaCl2, and 3 mM MgCl2
	Assay	N/A
	PubMed ID	22484812

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_856	RNA	UGGGCCGGAGGUUAGCUUGCCCAUGGCAAGCAGGGCGCCACGGACCCA	56.25%
Apta_370	RNA	GGGAGGACGCGUCGCCGUAAUGGAUGUUUUGCUCCCUG	55.00%
Apta_132	RNA	GGGAGGACGAUGCGGCGUUUCCUCUGGUUCGUCCCCAGACGACUCGCCCGA	54.90%
Apta_131	RNA	GGGAGGACGAUGCGGUCCUGUCGUCUGUUCGUCCCCAGACGACUCGCCCGA	52.94%
Apta_133	RNA	GGGAGGACGAUGCGGUGAGUCGUUCCCUUCGUCCCCAGACGACUCGCCCGA	52.94%
Apta_135	RNA	GGGAGGACGAUGCGGAUUCUGGUUACUGGCCGCCCCAGACGACUCGCCCGA	52.94%
Apta_315	RNA	GGGAGGACGAUGCGGUCGUAUUAUCCGCUGCACGCCAGACGACUCGCCCGA	52.94%
Apta_1126	DNA	TCGGGCGAGTCGTCTGCGGGCGGATAGACTACGACACCGCATCGTCCTCCC	52.94%
Apta_447	RNA	ACGCUCAACGAGCCAGGAACAUCGACGUCAGCAAACGCGAGCGCAACCAGUAACACC	52.63%
Apta_715	RNA	GGCGCUGCACGCCGAAAGGCCCGUUGAAACGUC	52.50%
Apta_758	RNA	GGCUUUCGGGCUUUCGGCAACAUCAGCCCCUCAGCC	52.50%
Apta_134	RNA	GGGAGGACGAUGCGGGCCGUUGUUGUGUGCCGCCCCAGACGACUCGCCCGA	50.98%
Apta_312	RNA	GGGAAAAGAGACGGCCGGCGCCAUAGCCGAGAUCCGAGGUGUUGCCGAGAA	50.98%
Apta_305	RNA	GGGAGGACGAUGCGGAUCGCCCUGAACCGGCCCAGCAGACUGCUGACGGCACGAUCCGCAUCGUCCUCCC	50.00%
Apta_314	RNA	GGUUACCAGCCUUCACUGCUCCCGGACGCGUCUGUAUCCGCUACCCGCCGCACCACGGUCGGUCACAC	50.00%
Apta_367	RNA	CGAGCGUAGAAUGUCUUCCCACUAGACGUCGUUCGGCCCC	50.00%
Apta_521	RNA	GGGUUGGGAAGAAACUGUGGCACUUCGGUGCCAGCAACCC	50.00%
Apta_560	RNA	GGAAGAGAUGGCGACUAAAACGACUUGUCGC	50.00%
Apta_711	RNA	GGCGAUACCAGCCGAAAGGCCCUUGGCAGCGUC	50.00%
Apta_1046	DNA	TCGCATGGAGGGCAGAGCCGCCTGCCGGGATCCGGCCCTCTTGGGCGGGC	50.00%

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