AptaDB: Result

Interaction ID: 144

Aptamer sequence: GTTGACGGGCGATTGGTCTT

Target unique ID: P02741

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_141	PF-aptamer	Protein	CRP_HUMAN	23.58 nM	50 mM NaH2PO4, pH 8; 150 mM NaCl; 5 mM KCl; 2 mM MgCl2; and 0.05% Tween-20; RT	28367958

Aptamer Sequence:	GTTGACGGGCGATTGGTCTT
The optimal secondary structure in dot-bracket notation:	......((((.....)))).
The centroid secondary structure in dot-bracket notation:	......((((.....)))).

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_141	Description	PF-aptamer
Aptamer chemistry	DNA	Length	20 nt
GC content	55.0%	Molecular weight	6,434.93 Da
Molarity of 1 μg/μl solution	155.40 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted binding
Sequence	GTTGACGGGCGATTGGTCTT
Applications	Binding to target proteins

Type	Detail	Type	Detail
Uniprot ID	P02741	Protein name	C-reactive protein [Cleaved into: C-reactive protein(1-205)]
Gene name(s)	CRP PTX1	Organism	C-reactive protein [Cleaved into: C-reactive protein(1-205)]
Status	reviewed in uniprot database	Length	224
Mass	25,039	Activity regulation	N/A
Involvement in disease	N/A	Catalytic activity	N/A
PDB ID(s)	1B09;1GNH;1LJ7;3L2Y;3PVN;3PVO;7PK9;7PKB;7PKD;7PKE;7PKF;7PKG;7PKH;
Function	Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine.

	Interaction ID	144
	Target type	Protein
	Target unique ID	P02741
	Activity	23.58 nM
	Binding Conditions/Buffer	50 mM NaH2PO4, pH 8; 150 mM NaCl; 5 mM KCl; 2 mM MgCl2; and 0.05% Tween-20; RT
	Assay	Representative duplicated results of dissociation constant of selected PFaptamer
	PubMed ID	28367958

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_390	DNA	GGTGCGGCGGGACTAGTGGGTGTG	58.33%
Apta_483	DNA	ATTGGGAGGGATTGGGTGGG	55.00%
Apta_359	DNA	GGGAACGCGTTATTGGGTAACTTCCC	53.85%
Apta_361	DNA	GGGAACGCCCGTATTGCTCGGTTCCC	53.85%
Apta_124	DNA	GGTGGTGGGGGGGGTTGGTAGGGTGTCTTC	53.33%
Apta_1241	DNA	GGTGTGGAGTGGTGTGTGTTGTTGTTTGTC	53.33%
Apta_1245	DNA	AGTGTGAAGTGGTGTGTGTTGTTGTTTGTC	53.33%
Apta_1246	DNA	GGAGATGTATGAGCGGGTGTTTGTGTTTGC	53.33%
Apta_757	DNA	GGTGGTGGTGGTTGTGGTGGTGG	52.17%
Apta_669	DNA	AACGTGGGAGGGCGGTGGTGTTGAA	52.00%
Apta_62	DNA	AGTCCGTGGTAGGGCAGGTTGGGGTGACT	51.72%
Apta_64	DNA	ACCGTGTGGAGGGTGTT	50.00%
Apta_208	DNA	AGGAAGGGGTGGAAT	50.00%
Apta_209	DNA	AAGGCTTTAGGTCTG	50.00%
Apta_211	DNA	GGTTGGTGTGGTTGG	50.00%
Apta_350	DNA	GGTGGTGGTGGTTGTGGTGGTGGTGG	50.00%
Apta_420	DNA	AGGGACGGGCTAAGTAACTGTGGAGGGT	50.00%
Apta_538	DNA	GTGTTGTCTCTCTGTGTCTC	50.00%
Apta_631	DNA	GGGATCGAAACGTAGCGCCTTCGATCCC	50.00%
Apta_671	DNA	GCATCTGATCGGGTGTGGGTGGCGTAAAGG	50.00%

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