Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 693
Aptamer sequence: GCACACCGATGGCGGTCCTGTTTAGGGGGTGTGCGTGGGGAGGTGCGGTTGC
Target unique ID: 7955
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_650 Rd29C33-T5 Molecule Melamine 1.51 μM Cyanuric acid, Ammeline, Ammelide 27171923
Structure information of aptamer
Aptamer Sequence: GCACACCGATGGCGGTCCTGTTTAGGGGGTGTGCGTGGGGAGGTGCGGTTGC
The optimal secondary structure in dot-bracket notation: ((((.((.((((((.((((.....)))).))).))).))...))))......
The centroid secondary structure in dot-bracket notation: ((((.((.((((((.((((.....)))).))).))).))...))))......
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_650 Description Rd29C33-T5
Aptamer chemistry DNA Length 52 nt
GC content 67.3% Molecular weight 16,276.36 Da
Molarity of 1 μg/μl solution 61.44 μM Number of G-quadruplexes 2
G-Score 19 Function Target detection
Sequence GCACACCGATGGCGGTCCTGTTTAGGGGGTGTGCGTGGGGAGGTGCGGTTGC
Applications Detection of melamine
Target information
Type Detail Type Detail
PubChem ID 7955 Molecular name Melamine
Molecular formula C3H6N6 Molecular weight 126.12
IUPAC name 1,3,5-triazine-2,4,6-triamine InChIKey JDSHMPZPIAZGSV-UHFFFAOYSA-N
LogP -1.382 Topological polar surface area 116.73
Hydrogen bond acceptor 6 Hydrogen bond donor 3

Synonym(s):
MELAMINE; 1,3,5-Triazine-2,4,6-triamine; 108-78-1; Cyanuramide; Cyanurotriamide; Cyanurotriamine; Isomelamine; Theoharn; Teoharn; Triaminotriazine; Cyanuric triamide; Hicophor PR; s-Triazinetriamine; Aero; Yukamelamine; Pluragard; Cymel; 2,4,6-Triamino-1,3,5-triazine; Virset 656-4; 2,4,6-Triamino-s-triazine; Spinflam ML 94M; 2,4,6-Triaminotriazine; Pluragard C 133; ADK Stab ZS 27; Mark ZS 27; DG 002 (amine); Melamine Monomer; NCI-C50715; Cyanurtriamide; s-Triazine, 2,4,6-triamino-; 1,3,5-Triazine-2,4,6(1H,3H,5H)-triimine; ZS 27; UNII-N3GP2YSD88; NSC 2130; DG 002; sym-Triaminotriazine; DTXSID6020802; N3GP2YSD88; CHEBI:27915; melamin; s-triaminotriazine; CCRIS 373; HSDB 2648; EINECS 203-615-4; BRN 0124341; 2,4,6-triamino sym-triazine; AI3-14883; AX2; Melamine, 99%; 2,6-Triaminotriazine; CYMEL (Salt/Mix); Metformin EP impurity D; 2,4,6-Triamino-1,3,5-triazine Monomer; DSSTox_CID_802; 2,6-Triamino-s-triazine; Melamine-13C3,15N3; 1,3,5-triazine-2,4,6(1H,3H,5H)triimine; EC 203-615-4; s-Triazine,4,6-triamino-; DSSTox_RID_75795; DSSTox_GSID_20802; SCHEMBL25853; Melamine, analytical standard; 4-26-00-01253 (Beilstein Handbook Reference); BIDD:ER0287; CHEMBL1231106; SCHEMBL12192199; 1,5-Triazine-2,4,6-triamine; 2,6-Triamino-1,3,5-triazine; NSC2130; NSC8152; Melamine 100 microg/mL in Water; ZINC897751; HY-Y1117; NSC-2130; NSC-8152; WLN: T6N CN ENJ BZ DZ FZ; Tox21_200503; 1,3,5-triazinane-2,4,6-triimine; BBL000010; MFCD00006055; s9212; STK378738; [1,3,5]triazine-2,4,6-triamine; 1,3, 5-Triazine-2,4,6-triamine; 2,4, 6-Triamino-1,3,5-triazine; AKOS005448714; CCG-266105; MCULE-1467355510; NCGC00164014-01; NCGC00164014-02; NCGC00258057-01; 1246816-14-7; 2,4,6-triamino-1,3,5-triazine;melamine;1,3,5-triazine-2,4,6-triamine;[1,3,5]triazine-2,4,6-triamine;s-triazine, 4,6-diamino-1,2-dihydro-2-imino-;2,4,6-triamino-1,3,5-triazine melamine 1,3,5-triazine-2,4,6-triamine [1,3,5]triazine-2,4,6-triamine s-triazine, 4,6-diamino-1,2-dihydro-2-imino-; AC-34715; CAS-108-78-1; VS-00405; 1,3,5-Triazine-2,4,6-triamine monomer; Melamine 1.0 mg/ml in Dimethyl Sulfoxide; CS-0016866; FT-0609833; FT-0670982; FT-0670983; Melamine; 1,3,5-Triazine-2,4,6-triamine; T0337; 1,3,5-Triazine-2,4,6-triamine (Melamine); 1,5-Triazine-2,4,6(1H,3H,5H)-triimine; Melamine 100 microg/mL in Acetonitrile/Water; 4,6-Diamino-1,2-dihydro-2-imino-S-Triazine; C08737; E76265; 78403-EP2270101A1; 78403-EP2270113A1; 78403-EP2272849A1; 78403-EP2272935A1; 78403-EP2276751A1; 78403-EP2289896A1; 78403-EP2298828A1; 78403-EP2301924A1; 78403-EP2301983A1; 78403-EP2308856A1; 78403-EP2374895A1; s-Triazine, 4,6-diamino-1,2-dihydro-2-imino-; Q212553; J-002191; 1,3,5-Triazine-2,4,6-triamine (ACD/Name 4.0); Melamine, >=95.0% (HPLC), pharmaceutical impurity standard; Melamine, United States Pharmacopeia (USP) Reference Standard; N,N',N''-Tri-2-pyridinyl-1,3,5-triazine-2,4,6-triamine; Melamine, Pharmaceutical Secondary Standard; Certified Reference Material; 5432-64-4

Activity data

No relevant experimental diagram

 Interaction ID 693
Target type Molecule
Target unique ID 7955
Activity 1.51 μM
Binding Conditions/Buffer

Cyanuric acid, Ammeline, Ammelide
Assay

N/A
PubMed ID 27171923
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_656 DNA GCACACCGATGGCGGTCCTGTTTTACGGTAGCTTATATGCAGGGGGTGTGCGTGGGGAGGTGCGGTTGC 75.36%
Apta_649 DNA GCACACCGATGGCGGTCCTGTTTAGGGGGTGTGCGTG 71.15%
Apta_654 DNA GCACACCGATGGCGGTCCTGTTTTACGGTAGCTTATATGCAGGGGGTGTGCGTG 70.37%
Apta_648 DNA GCACACCGATGGCGGTCCTGTTTAGGGGGTGTGC 65.38%
Apta_657 DNA CCTGCACCTCGTCCAGCATGCACACCGATGGCGGTCCTGTTTTACGGTAGCTTATATGCAGGGGGTGTGCGTGGGGAGGTGCGGTTGC 59.09%
Apta_744 DNA GTGGCCAGTCACTCAATTGGGTGTAGGGGTGGGGATTGTGGGTTG 57.69%
Apta_857 DNA GCTATGGGTGGTCTGGTTGGGATTGGCCCCGGGAGCTGGC 57.69%
Apta_1229 DNA CACGGGCAGAGGGATAGGTTGTTGACGGGGCTGGTGGGTGGGTGCGCTCGCGCTATCGTGG 57.38%
Apta_1267 DNA GGCACGGCAAAGGGGTACAGCCTACCGAACCGTGGCTGTAAGGGTGGTTGTGGTGTG 56.14%
Apta_217 DNA CGCCTGATTAGCGATACTCAGGCGTTGGGTGGGTGGGTGGG 55.77%
Apta_263 DNA AGAGGGGAGGGTCGGGTATCGGCGTGTTCGGGGGATCTGC 55.77%
Apta_282 DNA ATCCATGGGGCGGAGATGAGGGGGAGGAGGGCGGGTACCCGGTTGAT 55.77%
Apta_344 DNA CACTACAGAGGTTGCGTCTGTCCCACGTTGTCATGGGGGGTTGGCCTG 55.77%
Apta_820 DNA TCCCACGATCTCATTAGTCTGTGGATAAGCGTGGGACGTCTATGA 55.77%
Apta_869 DNA ACTAGGACGCTTGGGAGGGGGGGTGGGGTGTCCGGTCGCG 55.77%
Apta_880 DNA GCCGCACAATCGGGTTGGGCAGGGAGGGCACGTGTGGCGC 55.77%
Apta_1205 DNA GGCAGGTGGTGTTGGTTGGTTGTGCGTGGAGTTGG 55.77%
Apta_1258 DNA GGCGAAGGAGTCATGTAGGTGTGGTCGAGACCGCTGTGCT 55.77%
Apta_140 DNA GGCAGGAAGACAAACACGATGGGGGGGTATGATTTGATGTGGTTGTTGCATGATCGTGGTCTGTGGTGCTGT 55.56%
Apta_46 DNA CGGGTGGGAGTTGTGGGGGGGGGTGGGAGGGTT 53.85%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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