AptaDB: Result

Interaction ID: 446

Aptamer sequence: AAAGACCGTTTTTTAAAACGCTCAATATACACGACATAAA

Target unique ID: Q13651

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_440	446	Protein	I10R1_HUMAN	10 nM	100 mM NaCl Selection Buffer (20 mM, HEPES, 2 mM CaCl2, 0.1 mg/mL BSA)	26007661

Aptamer Sequence:	AAAGACCGTTTTTTAAAACGCTCAATATACACGACATAAA
The optimal secondary structure in dot-bracket notation:	...((.(((((....))))).)).................
The centroid secondary structure in dot-bracket notation:	...((.(((((....))))).)).................

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_440	Description	446
Aptamer chemistry	DNA	Length	40 nt
GC content	30.0%	Molecular weight	12,247.97 Da
Molarity of 1 μg/μl solution	81.65 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted binding
Sequence	AAAGACCGTTTTTTAAAACGCTCAATATACACGACATAAA
Applications	Bind human receptors and cross-react with their murine orthologs

Type	Detail	Type	Detail
Uniprot ID	Q13651	Protein name	Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)
Gene name(s)	IL10RA IL10R	Organism	Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)
Status	reviewed in uniprot database	Length	578
Mass	63,003	Activity regulation	N/A
Involvement in disease	Inflammatory bowel disease 28, autosomal recessive (IBD28)	Catalytic activity	N/A
PDB ID(s)	1J7V;1LQS;1Y6K;1Y6M;1Y6N;5IXI;6X93;
Function	Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.

No relevant experimental diagram	Interaction ID	446
	Target type	Protein
	Target unique ID	Q13651
	Activity	10 nM
	Binding Conditions/Buffer	100 mM NaCl Selection Buffer (20 mM, HEPES, 2 mM CaCl2, 0.1 mg/mL BSA)
	Assay	N/A
	PubMed ID	26007661

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_980	DNA	AACGAGCACGCTTTGTGTACAGCCACTAAATAAGGTATGTAGTCAGCACCCTCGTAAC	53.45%
Apta_845	DNA	CCAAACGCGCTGGTTTGGAATGCTTAGAGTTTGATCGATGCCTAA	53.33%
Apta_188	DNA	AAAAAAACTTTAAATCTGAGATCTCAAAAT	52.50%
Apta_363	DNA	ATTGACCGCTGTGTGACGCAACACTCAAT	52.50%
Apta_512	DNA	ATAGGACGATTATCGAAAATCACCAGATTGGACCCTGGTTAACGAT	52.17%
Apta_643	DNA	ACCGATCCATCGAGTTTCTGAGAAAGGCCCGGAGAAACCGCGAGA	51.11%
Apta_597	DNA	TACTGGGCTGGGCTTGGATTAGATCACAGTGGAACATACAGGACACACG	51.02%
Apta_139	DNA	GATAAACGCCTTGATTAAAGGCCCAGTTCTTTAGGCCTACACGTGCTGCGACATTAATT	50.85%
Apta_222	DNA	AGCGACTGACGATCTTGAGTAAACCGCTCATCCACGTAGT	50.00%
Apta_406	DNA	AAAGCCCACTGCATAGAGGCCGCTCAACATGCGAGCCGGT	50.00%
Apta_441	DNA	TGAATCTCGCGCTCGTTGGTACCCTTAAAATAAAGGCATA	50.00%
Apta_1025	DNA	GAAGAGTAGATGAAACGTTTTTTCGCCCGATAAAAGGGACGTGCGTCAGACA	50.00%
Apta_847	DNA	CACTAGGATCTAGGGAAAAATCTCGTAAATACTATACTCCTGAGC	48.89%
Apta_614	DNA	AATCGCATTACCTTATACCAGCTTATTCAATTACGTCTGCACATACCAGCTTATTCAATT	48.33%
Apta_995	DNA	GCAATGGTACGGTACTTCCCCACCCCACGCTGCTCCCAAAAGTGCACGCTACTTTGCTAA	48.33%
Apta_395	DNA	AATCCACGTATCGACTAGCTCAAACCAGCCTGATAGAGCCATTCGCTTTA	48.00%
Apta_514	DNA	ACTCAGCACGCGTGTAGGGAAAACCAACCGCCCACAAGCTGCATGCAACG	48.00%
Apta_783	DNA	AAGGGGTTGGGTGGGTTTATACAAATTAATTAATATTGTATGGTATATTT	48.00%
Apta_186	DNA	AGGAACGCTTTAGGTCTGAGATCTCGGAAT	47.50%
Apta_187	DNA	ACCAACCCTTTACCTCTGAGATCTCCCAAT	47.50%

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