AptaDB: Result

Interaction ID: 445

Aptamer sequence: TAACACTCGATTCTCCTAGCCCGCTAGAAATTCCCCTCCC

Target unique ID: Q13651

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_439	436	Protein	I10R1_HUMAN	65 nM	100 mM NaCl Selection Buffer (20 mM, HEPES, 2 mM CaCl2, 0.1 mg/mL BSA)	26007661

Aptamer Sequence:	TAACACTCGATTCTCCTAGCCCGCTAGAAATTCCCCTCCC
The optimal secondary structure in dot-bracket notation:	...............((((....)))).............
The centroid secondary structure in dot-bracket notation:	...............((((....)))).............

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_439	Description	436
Aptamer chemistry	DNA	Length	40 nt
GC content	52.5%	Molecular weight	12,031.75 Da
Molarity of 1 μg/μl solution	83.11 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted binding
Sequence	TAACACTCGATTCTCCTAGCCCGCTAGAAATTCCCCTCCC
Applications	Bind human receptors and cross-react with their murine orthologs

Type	Detail	Type	Detail
Uniprot ID	Q13651	Protein name	Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)
Gene name(s)	IL10RA IL10R	Organism	Interleukin-10 receptor subunit alpha (IL-10 receptor subunit alpha) (IL-10R subunit alpha) (IL-10RA) (CDw210a) (Interleukin-10 receptor subunit 1) (IL-10R subunit 1) (IL-10R1) (CD antigen CD210)
Status	reviewed in uniprot database	Length	578
Mass	63,003	Activity regulation	N/A
Involvement in disease	Inflammatory bowel disease 28, autosomal recessive (IBD28)	Catalytic activity	N/A
PDB ID(s)	1J7V;1LQS;1Y6K;1Y6M;1Y6N;5IXI;6X93;
Function	Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.

No relevant experimental diagram	Interaction ID	445
	Target type	Protein
	Target unique ID	Q13651
	Activity	65 nM
	Binding Conditions/Buffer	100 mM NaCl Selection Buffer (20 mM, HEPES, 2 mM CaCl2, 0.1 mg/mL BSA)
	Assay	N/A
	PubMed ID	26007661

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_254	DNA	CCCGCTGTTCTCCCCCCCCCGCTGAGATCCCTGT	57.50%
Apta_448	DNA	TAACTCACTCCATACTCACTTGCTGATTCGCCAACAACACACCCTTAAACAGTCCC	57.14%
Apta_395	DNA	AATCCACGTATCGACTAGCTCAAACCAGCCTGATAGAGCCATTCGCTTTA	54.00%
Apta_733	DNA	TAGGCAGTGGTTTGACGTCCGCATGTTGGGAATAGCCACGCCT	53.49%
Apta_969	DNA	TAACCACCCCACCTCGCTCCCGTGACACTAATGCTAATTCCAA	53.49%
Apta_635	DNA	TAGCCGGATCGCGCTGGCCAGATGATATAAAGGGTCAACCCCCCA	53.33%
Apta_636	DNA	TAGCCGGATCGCGCTGGCCAGATGATATAAAGGGTCAGCCCCCCA	53.33%
Apta_638	DNA	TAGCCGGATCGCGCTGGCCAGATGATATAAAGGGTCAACCCCCCG	53.33%
Apta_1127	DNA	TCGGGCGAGTCGTCTGCGAGGCAACAAGCTCGTAATCCGCATCGTCCTCCC	52.94%
Apta_166	DNA	ATCGCGCTCTCCTGCTTAAGCAGCTATCAAATAGCCCACT	52.50%
Apta_249	DNA	CCCTGTTCCCCCTCCGCCGCTTGACTCTCC	52.50%
Apta_291	DNA	AAAAATCTAGGCGCTGAAGCCCCGCTTCCTTACCTTCAC	52.50%
Apta_386	DNA	GGAAAAGATGGTATGGGCCCTAGAAAGTCCACCCGGCGCC	52.50%
Apta_602	DNA	GGGCGAGAACAGTGTCCCAGTCGCTAGTTTTCTCTGCCC	52.50%
Apta_1214	DNA	GTCCATTATTCTGGTAGCGTTGAACAACATTCAACACGCC	52.50%
Apta_637	DNA	TAGCCGGATCGCGTTGGCCAGATGATATAAAGGGTCAACCCCCCA	51.11%
Apta_639	DNA	CTAAGCACAGGGAAACCAGCTAATGAGTTAGGCCTGTCCCCCACG	51.11%
Apta_167	DNA	TGCTCCTTGGCCTTAGCCCTGGAACCATCAATCCTCTTCG	50.00%
Apta_253	DNA	CCCTGTTCGCTATCCCCCATCCCCCGATTGC	50.00%
Apta_360	DNA	GGGAACGCATACGCCGCAGTATTTCCC	50.00%

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