AptaDB: Result

Interaction ID: 226

Aptamer sequence: AGCGACTGACGATCTTGAGTAAACCGCTCATCCACGTAGT

Target unique ID: P05121

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_222	R9chSM-20	Protein	PAI1_HUMAN	920 pM	20 mM HEPES (pH 7.4), 50 mM NaCl, 2 mM CaCl2, and 0.1% BSA	19284310

Aptamer Sequence:	AGCGACTGACGATCTTGAGTAAACCGCTCATCCACGTAGT
The optimal secondary structure in dot-bracket notation:	....((((.((....(((((.....)))))....))))))
The centroid secondary structure in dot-bracket notation:	....(((.(((....(((((.....)))))....))))))

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_222	Description	R9chSM-20
Aptamer chemistry	DNA	Length	40 nt
GC content	50.0%	Molecular weight	12,504.84 Da
Molarity of 1 μg/μl solution	79.97 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted therapy
Sequence	AGCGACTGACGATCTTGAGTAAACCGCTCATCCACGTAGT
Applications	Adjuvant to traditional chemotherapy for breast cancer

Type	Detail	Type	Detail
Uniprot ID	P05121	Protein name	Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1)
Gene name(s)	SERPINE1 PAI1 PLANH1	Organism	Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1)
Status	reviewed in uniprot database	Length	402
Mass	45,060	Activity regulation	N/A
Involvement in disease	Plasminogen activator inhibitor-1 deficiency (PAI-1D)	Catalytic activity	N/A
PDB ID(s)	1A7C;1B3K;1C5G;1DB2;1DVM;1DVN;1LJ5;1OC0;3CVM;3EOX;3PB1;3Q02;3Q03;3R4L;3UT3;4AQH;4G8O;4G8R;4IC0;5BRR;5ZLZ;6GWN;6GWP;6GWQ;6I8S;6ZRV;7AQF;7AQG;9PAI;
Function	Serine protease inhibitor. Inhibits TMPRSS7.

No relevant experimental diagram	Interaction ID	226
	Target type	Protein
	Target unique ID	P05121
	Activity	920 pM
	Binding Conditions/Buffer	20 mM HEPES (pH 7.4), 50 mM NaCl, 2 mM CaCl2, and 0.1% BSA
	Assay	N/A
	PubMed ID	19284310

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_164	DNA	TATAGACCACAGCCTGAGATTAACCACCAACCCAGGACT	57.50%
Apta_968	DNA	TAACACGACAGACGTTCGGAGGTCGAACCCTGACAGCGTGGGC	55.81%
Apta_643	DNA	ACCGATCCATCGAGTTTCTGAGAAAGGCCCGGAGAAACCGCGAGA	55.56%
Apta_434	DNA	ACACGACGGGAATACTGACTCTCCCCCATGT	55.00%
Apta_438	DNA	AGCCATGACGATGTCGTTACGTAGATGCAGAGACTCCTAA	55.00%
Apta_438	DNA	AGCCATGACGATGTCGTTACGTAGATGCAGAGACTCCTAA	55.00%
Apta_446	DNA	AGCCATGACGATGTCGTTACGTAGATGCATAGACTCCTAA	55.00%
Apta_1059	DNA	TCGTGACGCCGTGCAGTTACCGATACGAGCCTCGTTTTG	55.00%
Apta_1138	DNA	GCAGTGTGGGCGAATCTATGCGTACCGTTCGATATCGTG	55.00%
Apta_1254	DNA	GGCAGTGTGGGCGAATCTATGCGTACCGTTCGATATCGTG	55.00%
Apta_355	DNA	GATGCAGCCACCTACATTGCAGGTTTTATAATACAACTACGCGCCGTTCGCAGGCTAGTT	53.33%
Apta_585	DNA	GATCGAGGGCAGCGATAGCTGGGCTAATAAGGTTAGCCCCATCGGTC	53.19%
Apta_163	DNA	GCGCATGACCATTGATGTCTGCACCATCAGAGGCAGAG	52.50%
Apta_186	DNA	AGGAACGCTTTAGGTCTGAGATCTCGGAAT	52.50%
Apta_215	DNA	AGGAAGGCTTTAGGTCCGAGATCTCGGAAT	52.50%
Apta_227	DNA	ACGCGCCTATGGTGCATCGCATGCCGACC	52.50%
Apta_273	DNA	ATAAGCTGAGCATCTTAGATCCCCGTCAAGGGCAGCGTAA	52.50%
Apta_274	DNA	GATACTGAGCATCGTACATGATCCCGCAACGGGCAGTATT	52.50%
Apta_339	DNA	CACAGGCTACGGCACGTAGAGCATCACCATGATCCTGTGT	52.50%
Apta_363	DNA	ATTGACCGCTGTGTGACGCAACACTCAAT	52.50%

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