AptaDB: Result

Interaction ID: 274

Aptamer sequence: AACGCUCAACGUCAGAAGGCAACGUAUAGGCAAGCACACUUCGACAUGAGGC

Target unique ID: P09038

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_269	26A	Protein	FGF2_HUMAN	0.19 nM	1X PBS (10.1 mM Na2HPO4/1.8 mM KH2PO4/137 mM NaCl/2.7 mM KCl, pH 7.4)	7504300

Aptamer Sequence:	AACGCUCAACGUCAGAAGGCAACGUAUAGGCAAGCACACUUCGACAUGAGGC
The optimal secondary structure in dot-bracket notation:	....((((..(((.((((....................))))))).))))..
The centroid secondary structure in dot-bracket notation:	....((((..(((.((((....................))))))).))))..

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_269	Description	26A
Aptamer chemistry	RNA	Length	52 nt
GC content	51.9%	Molecular weight	17,007.06 Da
Molarity of 1 μg/μl solution	58.80 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted binding
Sequence	AACGCUCAACGUCAGAAGGCAACGUAUAGGCAAGCACACUUCGACAUGAGGC
Applications	Inhibit the first step in the signaling pathway of basic fibroblast growth factor: binding of the growth factor to Its cell-surface receptors

Type	Detail	Type	Detail
Uniprot ID	P09038	Protein name	Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2)
Gene name(s)	FGF2 FGFB	Organism	Fibroblast growth factor 2 (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2)
Status	reviewed in uniprot database	Length	288
Mass	30,770	Activity regulation	N/A
Involvement in disease	N/A	Catalytic activity	N/A
PDB ID(s)	1BAS;1BFB;1BFC;1BFF;1BFG;1BLA;1BLD;1CVS;1EV2;1FGA;1FQ9;1II4;1IIL;2BFH;2FGF;2M49;4FGF;4OEE;4OEF;4OEG;5X1O;6L4O;
Function	Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4.

	Interaction ID	274
	Target type	Protein
	Target unique ID	P09038
	Activity	0.19 nM
	Binding Conditions/Buffer	1X PBS (10.1 mM Na2HPO4/1.8 mM KH2PO4/137 mM NaCl/2.7 mM KCl, pH 7.4)
	Assay	Representative binding curves for high-affinity RNA ligands
	PubMed ID	7504300

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_270	RNA	CUGUCGAACAUGCUGAGGGUAACGUACUGGCAAGCUCACCUCAGCGUAGCUAa	58.49%
Apta_271	RNA	CUGUCGAGCAUGCUCAGGGUAACGUAUAGUCAAGACACCUCAAGUGUAACU	57.69%
Apta_1121	RNA	GACAGCGUGCCUAGAAGUCCAAGCUUAAAUAACCACGCUCGACAAGC	57.69%
Apta_447	RNA	ACGCUCAACGAGCCAGGAACAUCGACGUCAGCAAACGCGAGCGCAACCAGUAACACC	56.14%
Apta_51	RNA	GCCUUAGUAACGUGCUUUGAUGUCGAUUCGACAGGAGGC	55.77%
Apta_303	RNA	CCUCCGGCUCAUACCUUUUCGAAGACAAGCUUCGACAGGAGG	55.77%
Apta_153	RNA	CCACAGUUCAGAGGCACCGCGAACAAAACGCAAGACAGAGUGCCGACAAGAAC	54.72%
Apta_3	DNA	CCTGCCTTTGGCAGCCGGGCGAAGGCAACCCGACACCGACAGC	53.85%
Apta_92	RNA	ACAACUUAAUGCGACGUUGGUAAAGCAUAUCAAAC	53.85%
Apta_56	DNA	GCAGCTAAGCAGGCGGCTCACAAAACCATTCGCATGCGGC	51.92%
Apta_89	RNA	AAUAACCUUAAUGCGACGUUGGUUCGUCAACAUGG	51.92%
Apta_90	RNA	ACAACCUAAAUGCGACGUUGGGUCAAAAACGUGAA	51.92%
Apta_1166	RNA	GAUGUAACUGAAUGAAAUGGUGAAGGACGGGUCCAGUAGGCUGC	51.92%
Apta_707	RNA	GGCCUAAAACAUACCAGAUUUCGAUCUGGAGAGGUGAAGAAUUCGACCACCUAGGCCGGU	51.67%
Apta_575	RNA	AGAGCUUGACGGUCCCGAGAGUCGAGCCCAAGCUGACACUGGACCUUUGCGGACCACGUGUUGAUCGUCG	51.43%
Apta_52	RNA	ACUGUCCUCCCUUCAGAGAGCGCGGGACCCUUAACUUGGGGCCCACGAACAGCUUCAGUUCCGUCUCGGCGU	51.39%
Apta_299	RNA	AUACCAGCUUAUUCAAUUGCCUGAAGACUGGAUAUACUCUUAAGCAUUUCUAUAAUCGAGAUAGUAAGUGCAAUCU	51.32%
Apta_624	RNA	GGGAAUGGAUCCACAUCUACGAAUUCGAAUUGCCGUAAUUUCCCGUGGAGCGAUGCUUCACUGCAGACUUGACGAAGCUU	51.25%
Apta_696	RNA	GAGUGCGCCCAUUGAUAAGAGCGUAGGUUCAACGGAGUCGUAGUCGUUCUCAAGUUGACGGUGCAUUAGAGUCCU	50.67%
Apta_1055	RNA	CAAGCUUGCGGGUUGGCUUGUAACAAGAUCGCUACGUGUUGAACUCUGCAACACUGGUCGGAUAGCGUAAACGGG	50.67%

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