Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 1288
Aptamer sequence: GGAGGCGCCAACUGAAUGAAGGUGUAUUUCAGUUAAAGAACUUGCUGCUUCGGCAGCGUUCUGAGUUACUAGUCCAAUAAUCCGUAACUAGUCGCGUCAC
Target unique ID: 135435090
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_1226 | JX6 | Molecule | 9H-Purin-6-ol, 2-((phenylmethyl)amino)- | 441.9 nM | 500 µL 1 M Tris-HCl, pH 7.4 | 26538152 |
Structure information of aptamer
| Aptamer Sequence: | GGAGGCGCCAACUGAAUGAAGGUGUAUUUCAGUUAAAGAACUUGCUGCUUCGGCAGCGUUCUGAGUUACUAGUCCAAUAAUCCGUAACUAGUCGCGUCAC |
| The optimal secondary structure in dot-bracket notation: | ...(((((.(((((((...........)))))))..(((((..(((((....)))))))))).((((((..............))))))....))))).. |
| The centroid secondary structure in dot-bracket notation: | ...(((((.(((((((...........)))))))..(((((..(((((....)))))))))).((((((..............))))))....))))).. |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_1226 | Description | JX6 |
| Aptamer chemistry | RNA | Length | 100 nt |
| GC content | 47.0% | Molecular weight | 32,108.00 Da |
| Molarity of 1 μg/μl solution | 31.14 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Target detection |
| Sequence | GGAGGCGCCAACUGAAUGAAGGUGUAUUUCAGUUAAAGAACUUGCUGCUUCGGCAGCGUUCUGAGUUACUAGUCCAAUAAUCCGUAACUAGUCGCGUCAC | ||
| Applications | Detection of benzylguanine | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| PubChem ID | 135435090 | Molecular name | 9H-Purin-6-ol, 2-((phenylmethyl)amino)- |
| Molecular formula | C12H11N5O | Molecular weight | 241.25 |
| IUPAC name | 2-(benzylamino)-1,7-dihydropurin-6-one | InChIKey | XWNJMSJGJFSGRY-UHFFFAOYSA-N |
| LogP | 1.258 | Topological polar surface area | 86.46 |
| Hydrogen bond acceptor | 4 | Hydrogen bond donor | 3 |
Synonym(s): 5711-37-5; 2-(benzylamino)-9H-purin-6-ol; 9H-Purin-6-ol, 2-((phenylmethyl)amino)-; CHEMBL292057; 9H-Purin-6-ol, 2-[(phenylmethyl)amino]-; benzylguanine; n2-benzylguanine; benzylaminopurine hydroxide; SCHEMBL18251; 2-Benzylamino-9H-purin-6-ol; SCHEMBL16146131; DTXSID40205734; BDBM50013090; ZINC26161976; 6H-Purin-6-one,1,9-dihydro-2-[(phenylmethyl)amino]-
Activity data
 |
Interaction ID | 1288 |
| Target type | Molecule | |
| Target unique ID | 135435090 | |
| Activity | 441.9 nM | |
| Binding Conditions/Buffer | 500 µL 1 M Tris-HCl, pH 7.4 |
|
| Assay | Binding affinity of the JX1-6 aptamers for Atto488-bG as measured by FP |
|
| PubMed ID | 26538152 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_1223 | RNA | GGAGGCGCCAACUGAAUGAAAGGUUACGCUUCAACGCCGUGCAGCUGCUUCGGCAGGCUUGUGAGUACAUGGCCCAUUGAUCCGUAACUAGUCGCGUCAC | |
| Apta_1224 | RNA | GGAGGCGCCAACUGAAUGAAUGUUCUGGAUCUGCUAGAGACUAUCUGCUUCGGCAGCACUCUCCGUUAACAACACGUACAUCCGUAACUAGUCGCGUCAC | |
| Apta_1222 | RNA | GGAGGCGCCAACUGAAUGAAACCGUGCUAAGGAGUUGGACUCCGCUGCUUCGGCAGAGCGAUAUAGUGCCAGCUGAUACAUCCGUAACUAGUCGCGUCAC | |
| Apta_1221 | RNA | GGAGGCGCCAACUGAAUGAACGAGUUGAAAUGCGGAUCAAGUUACUGCUUCGGCAGUACCUAGUGGGAAAAGUUCUUGGGUCCGUAACUAGUCGCGUCAC | |
| Apta_1225 | RNA | GGAGGCGCCAACUGAAUGAAAGAGGUAACGAAAGAUGAUUGUGCCUGCUUCGGCAGUACAACUUCUCGGAUAAAUGAUUAUCCGUAACUAGUCGCGUCAC | |
| Apta_720 | RNA | GGGAGAAUUCCGACCAGAAGCUUAGUAUAGCGAGGUUUAGCUACACUCGUGCUGAUCGUUUGGUACGGGACCUGCGUGUAGCCCAUAUGUGCGUCUACAUGGAUCCUCA | |
| Apta_382 | RNA | GGCGUGACCUGAUGAGUCACGCAGACGCUAGCGAAUUGGUUCCUCGAAAGGGGAAAGCGUUAUUAAGAAACCAAAAUGUGUUACGAAACGUUCCC | |
| Apta_696 | RNA | GAGUGCGCCCAUUGAUAAGAGCGUAGGUUCAACGGAGUCGUAGUCGUUCUCAAGUUGACGGUGCAUUAGAGUCCU | |
| Apta_224 | RNA | GGGGCCACCAACGACAUUGAACCACGUAGGCUCGUUUCUGAGCCGAUCUCGAUGUUGAUAUAAAUAGUGCCCAUGGAUC | |
| Apta_225 | RNA | GGGGCCACCAACGACAUUUAUCGAAUUGAUAACCUUACGCGAGAGCGUAGUUCGUUGAUAUAAAUAGUGCCCAUGGAUC | |
| Apta_352 | RNA | GGGAGGACGAUGCGGUGGUCUCCCAAUUCUAAACUUUCUCCAUCGUAUCUGGGCAGACGACUCGCCCGA | |
| Apta_383 | RNA | GGCGUGACCUGAUGAGUCACGCUAAGGAGGAUUUCCGAAAGCGGCUACGGUCCGCCAGUGUUACGAAACGUUCCC | |
| Apta_460 | RNA | GGAUGGCAGCGGAGAGUUGCUUGGAAUGCGUUAUAGUCUCUUAGGUGUGUACAGCCCACACCACUCUCC | |
| Apta_612 | RNA | GGGCGACCCUGAUGAGCCUUAGGAUAUGCUUCGGCAGAAGGACGUCGAAACGGUGAAAGCCGUAGGUUGCCC | |
| Apta_984 | RNA | GGGAGGACGAUGCGGCGUAUUGCGCGAGGAUUAUCCGCUCAUCGUUGUUGUUGUGCAGACGACUCGCCCGA | |
| Apta_168 | RNA | AAUUAACCCUCACUAAAGGGAACUGUUGUGAGUCUCAUGUCGAAGAGCGGUUAAGGGAGAUUUAGGCAGCAGCUUGGACAGUGUAUCGGCUGAGUUGAGCGUCUAGUCUUGUCU | |
| Apta_893 | RNA | ACCGAGUCCAGAAGCUUGUAGUACUUAUGUCCCAUCGAACGCAGUGUAUCUUGCACCGACUCUCUGCCUAGAUGGAGUUGAAUUCUCCCUAUAGUGAGUCGUAUUAC | |
| Apta_895 | RNA | ACCGAGUCCAGAAGCUUGUAGUACUACCGCAACGUUGGCGUUCGGCGUUGGCCGCGUCAUCGCUAGCCUAGAUGGAGUUGAAUUCUCCCUAUAGUGAGUCGUAUUAC | |
| Apta_276 | RNA | GGACCGAGAAGUUACCCUGUAAUCUUAGGAUGAAUCGCAUGCUCUAGCGACCUUUUCGGCUUCGGCGUACGCACAUCGCAGCAAC | |
| Apta_305 | RNA | GGGAGGACGAUGCGGAUCGCCCUGAACCGGCCCAGCAGACUGCUGACGGCACGAUCCGCAUCGUCCUCCC |
DEV TOOL
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