AptaDB: Result

Interaction ID: 1222

Aptamer sequence: AGAGGCTACAGCGATAAGTCGACATTGCTGACCGTACCTAGTAATACGT

Target unique ID: P14151

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_1162	SC Aptamer	Protein	LYAM1_HUMAN	N/A	N/A	25826688

Aptamer Sequence:	AGAGGCTACAGCGATAAGTCGACATTGCTGACCGTACCTAGTAATACGT
The optimal secondary structure in dot-bracket notation:	........(((((((........)))))))..((((........)))).
The centroid secondary structure in dot-bracket notation:	........(((((((........)))))))...................

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_1162	Description	SC Aptamer
Aptamer chemistry	DNA	Length	49 nt
GC content	46.9%	Molecular weight	15,113.73 Da
Molarity of 1 μg/μl solution	33.17 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted therapy
Sequence	AGAGGCTACAGCGATAAGTCGACATTGCTGACCGTACCTAGTAATACGT
Applications	Inhibit L-selectin

Type	Detail	Type	Detail
Uniprot ID	P14151	Protein name	L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)
Gene name(s)	SELL LNHR LYAM1	Organism	L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)
Status	reviewed in uniprot database	Length	372
Mass	42,187	Activity regulation	N/A
Involvement in disease	N/A	Catalytic activity	N/A
PDB ID(s)	2LGF;3CFW;5VC1;
Function	Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells.

No relevant experimental diagram	Interaction ID	1222
	Target type	Protein
	Target unique ID	P14151
	Activity	N/A
	Binding Conditions/Buffer	N/A
	Assay	N/A
	PubMed ID	25826688

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_489	DNA	GGGGTTAAATATTCCCACATTGCCTGCGCCAGTACAAATAG	57.14%
Apta_220	DNA	ATCAACTCACCGTAGGTCTAGTGAGAACTTCAAGTCTACT	55.10%
Apta_274	DNA	GATACTGAGCATCGTACATGATCCCGCAACGGGCAGTATT	55.10%
Apta_339	DNA	CACAGGCTACGGCACGTAGAGCATCACCATGATCCTGTGT	55.10%
Apta_348	DNA	ACTTGCTCTGATGCGACAACCTTTTGCCCAGATAGTAAGT	55.10%
Apta_512	DNA	ATAGGACGATTATCGAAAATCACCAGATTGGACCCTGGTTAACGAT	55.10%
Apta_876	DNA	GTTGCGAAAGACAACGAATGCTTTGCCTGCCATAATTTGC	55.10%
Apta_1257	DNA	CGACGCACAGTCGCTGGTGCGTACCTGGTTGCCGTTGTGT	55.10%
Apta_1261	DNA	GGGCGGACGCTAGGTGGTGATGCTGTGCTACACGTGTTGT	55.10%
Apta_891	DNA	GGAGACCGTACCATCTGTTCGTGGAAGCGCTTTGCTCGTCCATTAGCCTTGTGCTCGTGC	55.00%
Apta_405	DNA	TCTAGCCCACTGCATAGAGGTAGCCACGTATGTGGGTGTTACCCATTCGTAGCTACCGGTG	54.10%
Apta_989	DNA	ATGCGGGTACATCTCTCCAACCAGTCAAACTGCTATGATAAGACCTCATTCAACCCCGGTA	54.10%
Apta_753	DNA	GGGCACAGACGGAAGATGAGAATTGTGGGGCTTAGTATAGTGAGGTGCGTGT	53.85%
Apta_694	DNA	ACTCACTATGGAAGAGATGGCGACATCTCTTCTCCGAGCCGGTCGAAATAGTGAGT	53.57%
Apta_158	DNA	CACAGGCTACGGCACGTAGAGCATCACCATGATCCTGTG	53.06%
Apta_260	DNA	GACGTTAAGCTAGCAGGTGTTAGGTCCCGTGGTGATGAAT	53.06%
Apta_491	DNA	TTGGGGTCTGCTCGGGATTGCGGAGAACGTGAATCT	53.06%
Apta_506	DNA	AAGCGCGCGAGACTACGTTTGTAGGGATACCGATGTCG	53.06%
Apta_822	DNA	TAGCCCTTCAACATAGTAATATCTCTGCATTCTGTGATG	53.06%
Apta_846	DNA	GTGCAGACAGCTAGTAGTGGTGACTTTCTGTCCAAATCAAGATAA	53.06%

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