Aptamer-target interaction descriptor
Aptamer-target interaction information
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_1200 | Aptamer 2 | Cell | Mycobacterium tuberculosis subsp. Tuberculosis | 97 nM | 20 mmol/L HEPES buffer at pH 7.35, 1 mmol/L MgCl2, 120 mmol/L NaCl, 1 mmol/L CaCl2, and 5 mmol/L KCl | 28689112 |
Structure information of aptamer
| Aptamer Sequence: | GGCACACAGGACTATACAGTGTTGCAGTGTTGCTG |
| The optimal secondary structure in dot-bracket notation: | (((((((..(((........)))...))).)))). |
| The centroid secondary structure in dot-bracket notation: | (((.(((....(........).....)))..))). |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_1200 | Description | Aptamer 2 |
| Aptamer chemistry | DNA | Length | 35 nt |
| GC content | 51.4% | Molecular weight | 10,826.97 Da |
| Molarity of 1 μg/μl solution | 92.36 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Target detection |
| Sequence | GGCACACAGGACTATACAGTGTTGCAGTGTTGCTG | ||
| Applications | Detection of H37Rv in clinical diagnosis | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| ATCC ID | 27294 | Cell name | Mycobacterium tuberculosis subsp. Tuberculosis |
| Category | Bacteria | Organism | N/A |
| Product type | N/A | Cell type | N/A |
| Morphology | N/A | Tissue | N/A |
| Disease | N/A | Product format | Frozen |
| Antigen expression | N/A | Genes expressed | N/A |
| Cell description | This strain has been assigned to Risk Group 3-agents associated with serious or lethal human disease for which preventive or therapeutic interventions may be available. |
|
|
| Application(s) | N/A | ||
Activity data
|
No relevant experimental diagram |
Interaction ID | 1262 |
| Target type | Cell | |
| Target unique ID | 27294 | |
| Activity | 97 nM | |
| Binding Conditions/Buffer | 20 mmol/L HEPES buffer at pH 7.35, 1 mmol/L MgCl2, 120 mmol/L NaCl, 1 mmol/L CaCl2, and 5 mmol/L KCl |
|
| Assay | N/A |
|
| PubMed ID | 28689112 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_1206 | DNA | GGCAGCAGCAATGTAACACTGTGTGTATGTGTTGG | |
| Apta_419 | DNA | ATCAGGGCTAAAGAGTGCAGAGTTACTTAG | |
| Apta_1261 | DNA | GGGCGGACGCTAGGTGGTGATGCTGTGCTACACGTGTTGT | |
| Apta_443 | DNA | GGCCATGACGATGTCGTTACGTAGATGCAGAGACTCCTAA | |
| Apta_1258 | DNA | GGCGAAGGAGTCATGTAGGTGTGGTCGAGACCGCTGTGCT | |
| Apta_360 | DNA | GGGAACGCATACGCCGCAGTATTTCCC | |
| Apta_630 | DNA | GACCAGGGCAAACGGTAGGGAGTGGTC | |
| Apta_1204 | DNA | GGCACGATGTGGCTACATCGATCGCGGTACTGGTG | |
| Apta_1204 | DNA | GGCACGATGTGGCTACATCGATCGCGGTACTGGTG | |
| Apta_649 | DNA | GCACACCGATGGCGGTCCTGTTTAGGGGGTGTGCGTG | |
| Apta_753 | DNA | GGGCACAGACGGAAGATGAGAATTGTGGGGCTTAGTATAGTGAGGTGCGTGT | |
| Apta_58 | DNA | GCACCTTGATGACATGATAGTCGTTGTGTATGCAGTTGGC | |
| Apta_438 | DNA | AGCCATGACGATGTCGTTACGTAGATGCAGAGACTCCTAA | |
| Apta_438 | DNA | AGCCATGACGATGTCGTTACGTAGATGCAGAGACTCCTAA | |
| Apta_444 | DNA | AGCCATTACGATGTCGTTACGTAGATGCAGAGACTCCTAA | |
| Apta_480 | DNA | CGGCACACCTCGGTCGGTTTGTATGGCGAGCTGGTTTTTT | |
| Apta_880 | DNA | GCCGCACAATCGGGTTGGGCAGGGAGGGCACGTGTGGCGC | |
| Apta_1215 | DNA | GTCGAATCAGCACCTCTGCATAGGTTACGTTTATACTGCG | |
| Apta_939 | DNA | TTGCCCACCGTACTGTGCAGGTCGAACTACAGGCACGTCGTG | |
| Apta_203 | DNA | GGAAGGCTTTAGGTCTGAGATCTCGG |
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