AptaDB: Result

Interaction ID: 1215

Aptamer sequence: TAGTTTTATTTGTTCATTTTGTGTATTGTTTTGA

Target unique ID: P03524

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_1155	GTE33	Protein	GLYCO_RABVE	431 nM	4.5 g/l glucose and 5 mmol/l MgCl2 in Dulbecco’s PBS	24486485

Aptamer Sequence:	TAGTTTTATTTGTTCATTTTGTGTATTGTTTTGA
The optimal secondary structure in dot-bracket notation:	..................................
The centroid secondary structure in dot-bracket notation:	..................................

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_1155	Description	GTE33
Aptamer chemistry	DNA	Length	34 nt
GC content	20.6%	Molecular weight	10,460.74 Da
Molarity of 1 μg/μl solution	95.60 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted therapy
Sequence	TAGTTTTATTTGTTCATTTTGTGTATTGTTTTGA
Applications	Inhibit the replication of RABV

Type	Detail	Type	Detail
Uniprot ID	P03524	Protein name	Glycoprotein
Gene name(s)	G	Organism	Glycoprotein
Status	reviewed in uniprot database	Length	524
Mass	58,658	Activity regulation	N/A
Involvement in disease	N/A	Catalytic activity	N/A
PDB ID(s)	3NFK;
Function	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane.

	Interaction ID	1215
	Target type	Protein
	Target unique ID	P03524
	Activity	431 nM
	Binding Conditions/Buffer	4.5 g/l glucose and 5 mmol/l MgCl2 in Dulbecco’s PBS
	Assay	The inhibition of non-RABV viral infections by aptamers in vitro
	PubMed ID	24486485

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_1154	DNA	TTAATTTTTTGATCTTTGATTGTTTTATTTTTTTTATTGTTTGTG	62.22%
Apta_216	DNA	TGGTTGGTTTTTGGTTTTTTTTTTTGGTTT	61.76%
Apta_1238	DNA	GGTTTTGTGTTTGTGTTTTGTGGTTGTTGT	61.76%
Apta_853	DNA	TGACCGAGTGTCTGGTCATTTTCGATGTCTGTTGTTAGGC	57.50%
Apta_1286	DNA	CTATACGTATTCTAACTTGTTACGTATTGGTCTCTTATTG	57.50%
Apta_1245	DNA	AGTGTGAAGTGGTGTGTGTTGTTGTTTGTC	55.88%
Apta_1247	DNA	GGTGGTTGCTGTTGTTTGTGGTTGGTGTGC	55.88%
Apta_1153	DNA	TATTTTTATATTTGTTTGACAGTCGCTTGCTTGTGTAGGCGTT	55.81%
Apta_493	DNA	GGGGTGGTGGGTTCTTTTTGTGGTATTGGTGTGGGGGGCA	55.00%
Apta_851	DNA	CCATGTTTTGTAGGTGTAATAGGTCATGTTAGGGTTTCTG	55.00%
Apta_1206	DNA	GGCAGCAGCAATGTAACACTGTGTGTATGTGTTGG	54.29%
Apta_482	DNA	AGCAAGGTTTGGTGTTGGTTGGTTGCTGGTTTTGGTTTC	53.85%
Apta_644	DNA	TCAATCTAACCATGCATGCAGTTTAGGCAGGATTCGTTATCGCAA	53.33%
Apta_1236	DNA	GGACTGTTGTGGTATTATTTTTGGTTGTGC	52.94%
Apta_1237	DNA	GGGGTTGTGTGGGGAGTTTGTCCTGTTGTG	52.94%
Apta_1240	DNA	GGAGTAGTGGGGATTGTGGTGTATGTTGTC	52.94%
Apta_1243	DNA	GGTGTTGTTGTTGGCTAGTTTGTTGTGGGC	52.94%
Apta_1244	DNA	GGAGATGTCAGTTGTGTGTGTGGTTATGGC	52.94%
Apta_1246	DNA	GGAGATGTATGAGCGGGTGTTTGTGTTTGC	52.94%
Apta_1280	DNA	TCATATCCTTCTTGGTATCATTGCGTCATTTAGTCATTCATGTTATTCCCGAGGG	52.73%

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