AptaDB: Result

Interaction ID: 1238

Aptamer sequence: AGTATGATATCGGTGTTTATGGTGTCTGTCTTCATACT

Target unique ID: CRL-1690

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_1176	WYZ-41a	Cell	T98G [T98-G]	1.0 nM	4.5 g/L glucose, 5 mM MgCl2, 0.1 mg/mL yeast tRNA, and 1 mg/mL BSA in Dulbecco’s PBS	29708252

Aptamer Sequence:	AGTATGATATCGGTGTTTATGGTGTCTGTCTTCATACT
The optimal secondary structure in dot-bracket notation:	(((((((...(((............)))...)))))))
The centroid secondary structure in dot-bracket notation:	(((((((...(((............)))...)))))))

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_1176	Description	WYZ-41a
Aptamer chemistry	DNA	Length	38 nt
GC content	36.8%	Molecular weight	11,710.53 Da
Molarity of 1 μg/μl solution	85.39 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted therapy
Sequence	AGTATGATATCGGTGTTTATGGTGTCTGTCTTCATACT
Applications	Diagnosis and effective therapy of glioma

Type	Detail	Type	Detail
ATCC ID	CRL-1690	Cell name	T98G [T98-G]
Category	Human cells	Organism	Homo sapiens, human
Product type	N/A	Cell type	N/A
Morphology	fibroblast	Tissue	Brain
Disease	Glioblastoma Multiforme	Product format	Frozen
Antigen expression	N/A	Genes expressed	N/A
Cell description	N/A
Application(s)	3D cell culture; Neuroscience

	Interaction ID	1238
	Target type	Cell
	Target unique ID	CRL-1690
	Activity	1.0 nM
	Binding Conditions/Buffer	4.5 g/L glucose, 5 mM MgCl2, 0.1 mg/mL yeast tRNA, and 1 mg/mL BSA in Dulbecco’s PBS
	Assay	Kd of full-length and truncated aptamers for T98G cells
	PubMed ID	29708252

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_1177	DNA	TCCTACTCGTGATATCGGTGTTTATGGTGTCTGTCTTCATGTAGGA	73.91%
Apta_1245	DNA	AGTGTGAAGTGGTGTGTGTTGTTGTTTGTC	63.16%
Apta_364	DNA	TATGGTATGCTGTGTGGTATGGGGTGGCGTGCTCT	60.53%
Apta_393	DNA	AGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCT	57.89%
Apta_407	DNA	GTGAATTGCGTTGAATTATGTTTTTTCAGTCATCACT	57.89%
Apta_1240	DNA	GGAGTAGTGGGGATTGTGGTGTATGTTGTC	57.89%
Apta_1241	DNA	GGTGTGGAGTGGTGTGTGTTGTTGTTTGTC	57.89%
Apta_391	DNA	ACCGTGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCACGGT	57.78%
Apta_260	DNA	GACGTTAAGCTAGCAGGTGTTAGGTCCCGTGGTGATGAAT	57.50%
Apta_482	DNA	AGCAAGGTTTGGTGTTGGTTGGTTGCTGGTTTTGGTTTC	56.41%
Apta_987	DNA	GTACTGTCAATTGGAAGTGGTGTTACGTTGTGTAGTCAAATCAGTGC	55.32%
Apta_72	DNA	AGTCAGTAGGTTGGTGTGGTTGGGGCTGACT	55.26%
Apta_184	DNA	AGGAAGGCTTTAGGTCTGAGATCTCGGAAT	55.26%
Apta_186	DNA	AGGAACGCTTTAGGTCTGAGATCTCGGAAT	55.26%
Apta_193	DNA	AGGAAGGCTTTAGGGTCTGAGATCTCGGAAT	55.26%
Apta_195	DNA	AGGAAGGCTTTAGGGGTCTGAGATCTCGGAAT	55.26%
Apta_196	DNA	AGGAAGGCTTTAGGTCTGAGATCTC	55.26%
Apta_392	DNA	GGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCT	55.26%
Apta_675	DNA	ACTGTCCGTCGGGTTTAGGGTGGCGTTCGG	55.26%
Apta_1238	DNA	GGTTTTGTGTTTGTGTTTTGTGGTTGTTGT	55.26%

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