AptaDB: Result

Interaction ID: 392

Aptamer sequence: GGAAAAGATGGTATGGGCCCTAGAAAGTCCACCCGGCGCC

Target unique ID: P30990

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_386	P108	Protein	NEUT_HUMAN	5 nM	SHMCK buffer containing 0.1% (w/v) HSA, 0.2% (w/v) CHAPS, 0.04% (w/v) CHS, and 0.1% (w/v) LM	12054450

Aptamer Sequence:	GGAAAAGATGGTATGGGCCCTAGAAAGTCCACCCGGCGCC
The optimal secondary structure in dot-bracket notation:	((......(((..(((((........))))).)))...))
The centroid secondary structure in dot-bracket notation:	........(((..(((((........))))).))).....

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_386	Description	P108
Aptamer chemistry	DNA	Length	40 nt
GC content	60.0%	Molecular weight	12,364.95 Da
Molarity of 1 μg/μl solution	80.87 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted binding
Sequence	GGAAAAGATGGTATGGGCCCTAGAAAGTCCACCCGGCGCC
Applications	Binding to GPCRs

Type	Detail	Type	Detail
Uniprot ID	P30990	Protein name	Neurotensin/neuromedin N [Cleaved into: Large neuromedin N (NmN-125); Neuromedin N (NN) (NmN); Neurotensin (NT); Tail peptide]
Gene name(s)	NTS	Organism	Neurotensin/neuromedin N [Cleaved into: Large neuromedin N (NmN-125); Neuromedin N (NN) (NmN); Neurotensin (NT); Tail peptide]
Status	reviewed in uniprot database	Length	170
Mass	19,795	Activity regulation	N/A
Involvement in disease	N/A	Catalytic activity	N/A
PDB ID(s)	2LNE;2LNF;2LNG;2LYW;2OYV;2OYW;3F6K;4PO7;5LUZ;6UP7;
Function	Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism.

No relevant experimental diagram	Interaction ID	392
	Target type	Protein
	Target unique ID	P30990
	Activity	5 nM
	Binding Conditions/Buffer	SHMCK buffer containing 0.1% (w/v) HSA, 0.2% (w/v) CHAPS, 0.04% (w/v) CHS, and 0.1% (w/v) LM
	Assay	N/A
	PubMed ID	12054450

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_257	DNA	GGCAGAAGAAATATCGAAACCCAGAATGGTCGGCCAGGCG	57.50%
Apta_60	DNA	GGAATGAGTGCCCTGCAAGCGAGGGCTAGC	55.00%
Apta_275	DNA	AGTTGAATGGTGTGGTCACTTCCAGTCCCGCAGGGCACAC	55.00%
Apta_560	RNA	GGAAGAGAUGGCGACUAAAACGACUUGUCGC	55.00%
Apta_1167	RNA	GGCGCGAGGAAGGAGGUCUGAGGAGGUCACUGCGCC	55.00%
Apta_439	DNA	TAACACTCGATTCTCCTAGCCCGCTAGAAATTCCCCTCCC	52.50%
Apta_462	DNA	GGTATAGACCCCTGAGTCCTACCGAGGGCACGGCA	52.50%
Apta_33	DNA	GCGGTAAACTGCGTCCGAAGGGGCTGCAGTGACCCGAATGGGTCCGCCGCGAAGCG	51.79%
Apta_32	DNA	CGGTAAACTGCGTCCGAAGGGGCTGCAGTGACCCGAATGGGTCCG	51.11%
Apta_486	DNA	GGGAGGGATTGGGTGGGCACAGCTCGCTGATAGGTCCTGGTCTCAC	51.06%
Apta_154	RNA	ACACGCGAGAUAGAGCGAGGCCUCCAAAAAUGGCCACGCCAGGAAGCAAGU	50.98%
Apta_146	DNA	GGTGCGGTTCGTGCGGTTGTAGTACTCGTGGCCG	50.00%
Apta_193	DNA	AGGAAGGCTTTAGGGTCTGAGATCTCGGAAT	50.00%
Apta_194	DNA	AGGAAGGCTTTAGGGTCTGAGATCTCGGGAAT	50.00%
Apta_195	DNA	AGGAAGGCTTTAGGGGTCTGAGATCTCGGAAT	50.00%
Apta_203	DNA	GGAAGGCTTTAGGTCTGAGATCTCGG	50.00%
Apta_251	DNA	GCCCTACATTCTGTGCGACTCCCCCCCCCGC	50.00%
Apta_392	DNA	GGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCT	50.00%
Apta_543	DNA	GGCACGTGTTGTCTCTCTGTGTCTCGTGCC	50.00%
Apta_663	DNA	CACGCACAGAAGACACCTACAGGGCCAGATCACAATCGGTTAGTGAACTCGTACGGCGCG	50.00%

ABOUT