Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 1217
Aptamer sequence: ACCTTGTACTGGTTACCTTGGCTAAAAAAAAAAAAAAAAAAAAAGTAAGCCGAAGCCATTACGTTTAGC
Target unique ID: P14151
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_1157 LS Circle Template Protein LYAM1_HUMAN N/A N/A 25826688
Structure information of aptamer
Aptamer Sequence: ACCTTGTACTGGTTACCTTGGCTAAAAAAAAAAAAAAAAAAAAAGTAAGCCGAAGCCATTACGTTTAGC
The optimal secondary structure in dot-bracket notation: .....(((.(((((...((((((........................))))))))))).))).......
The centroid secondary structure in dot-bracket notation: ....((((.(((((...((((((........................))))))))))).))))......
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_1157 Description LS Circle Template
Aptamer chemistry DNA Length 69 nt
GC content 33.3% Molecular weight 21,301.79 Da
Molarity of 1 μg/μl solution 46.94 μM Number of G-quadruplexes No QGRS found
G-Score N/A Function Targeted therapy
Sequence ACCTTGTACTGGTTACCTTGGCTAAAAAAAAAAAAAAAAAAAAAGTAAGCCGAAGCCATTACGTTTAGC
Applications Inhibit L-selectin
Target information
Type Detail Type Detail
Uniprot ID P14151 Protein name L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)
Gene name(s) SELL LNHR LYAM1 Organism L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)
Status reviewed in uniprot database Length 372
Mass 42,187 Activity regulation N/A
Involvement in disease N/A Catalytic activity N/A
PDB ID(s)
2LGF;3CFW;5VC1;
Function Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells.
Activity data

No relevant experimental diagram

 Interaction ID 1217
Target type Protein
Target unique ID P14151
Activity N/A
Binding Conditions/Buffer

N/A
Assay

N/A
PubMed ID 25826688
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_1159 DNA TGGGATACTGAACGGATGCCTTACAAAAAAAAAAAAAAAAAAAAACCTTATAGTTGTTGATTCCACCCG 55.07%
Apta_83 DNA GGCTTTACACTTTATGCTTCCGTAAAAACACAAACACACGCACATACATAAAATAACAATTTCACACAGGAAACAG 50.00%
Apta_788 DNA TACCAGTGCGATGCTCAGTAACTTTGAAGGAAAGGCTACAAACTCTTCCTGACGCATTCGGTTGAC 49.28%
Apta_980 DNA AACGAGCACGCTTTGTGTACAGCCACTAAATAAGGTATGTAGTCAGCACCCTCGTAAC 49.28%
Apta_1107 DNA GCGCGATGGACTGTACCTTCGGCGTAACTGATATTCCTGATGATTCTGGCGAGACGTAGCACAAACCCGGTGTATA 48.68%
Apta_1128 DNA GCCGAGATTGCACTTACTATCTCAATAGGGTAAAAAAAAAAAGTTGGTCCTATGGGTGGGTTGTTCAGTAATTGAATAAGCTGGTATGCGC 48.35%
Apta_435 DNA CCTTCGTTGTCTGCCTTCGTAGGACCGCAGACATCGACGCAGGGAAATTCCGCAAGTCCAGCCAAATGCCACCCTTCAGAATTCGCACCA 47.78%
Apta_232 DNA AGCAGCACAGAGGTCAGATGCTATGAGCAGATCCGATAGAAAGTTAATGCCCTAGAACATCCTATGCGTGCTACCGTGAA 47.50%
Apta_1112 DNA ATCCAGAGTGACGCAGCAGGGCACATTGTTCACACACAGATCACATTACGGAAAACACAACTACACGAAATGTCGTTGGTGGCCC 47.06%
Apta_1132 DNA GCCGAGATTGCACTTACTATCTGAAAGGGTGGAGATTGATAGGTATAGAGAAACGATAAGGGGGTGTAGAGTAATTGAATAAGCTGGTATGCGC 46.81%
Apta_1130 DNA GCCGAGATTGCACTTACTATCTATTAGGAATAAGGTATGAATAGAGATGTATAAGTTGTGTGGACGGTGTAATTGAATAAGCTGGTATGCGC 46.74%
Apta_153 RNA CCACAGUUCAGAGGCACCGCGAACAAAACGCAAGACAGAGUGCCGACAAGAAC 46.38%
Apta_395 DNA AATCCACGTATCGACTAGCTCAAACCAGCCTGATAGAGCCATTCGCTTTA 46.38%
Apta_889 DNA ACACTCTTTTGCTCGTGTTTTTGCCTGTTACATAAAATGAATCAGTGGATGTTTCCTTCT 46.38%
Apta_1068 DNA CGGGACAAGACAACGAACGAACAGGAAGAGAACCGGAATGCAGACGTCAGGG 46.38%
Apta_1171 DNA TTTTTTTTTTTCGCAGCACCCAAGAACAAGGACTGCTTAGGATTGCGATAGGTTCGG 46.38%
Apta_175 DNA AGCAGCACAGAGGTCAGATGAGGACTGTCGATAAGTATAATGGCAAGTAGCTCGATACATCCTATGCGTGCTACCGTGAA 46.25%
Apta_741 DNA ATCGTCTGCTCCGTCCAATAGCCTCACCCTGCATAATTTATAGACTACACTTAGGAATCGCTGCATTTGGTGTGAGGTCGTGC 45.78%
Apta_767 DNA GAATTCAGTCGGACAGCGACGGTGGGAGCCCCAAATAATTCTTGCGATTATTAGTGTAAGCGGATGGACGAATATCGTCTCCC 45.78%
Apta_1179 DNA GAATTCAGTCGGACAGCGAAGTAGTTTTCCTTCTAACCTAAGAACCCGCGGCAGTTTAATGTAGATGGACGAATACGTCTCCC 45.78%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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