Aptamer-target interaction descriptor
Aptamer-target interaction information
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_1098 | S3-2-3 | Cell | HCM-BROD-0020-C15 | 265 nM | 4.5 g/L glucose, 5 mM MgCl2, 1 mg/mL bovine serum albumin (BSA) and 0.1 mg/mL yeast tRNA in 0.01 M PBS | 34105524 |
Structure information of aptamer
| Aptamer Sequence: | ATGGCCAGGGGGGAGGGG |
| The optimal secondary structure in dot-bracket notation: | ....((........)).. |
| The centroid secondary structure in dot-bracket notation: | .................. |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_1098 | Description | S3-2-3 |
| Aptamer chemistry | DNA | Length | 18 nt |
| GC content | 77.8% | Molecular weight | 5,710.68 Da |
| Molarity of 1 μg/μl solution | 175.11 μM | Number of G-quadruplexes | 2 |
| G-Score | 20 | Function | Aptasensor |
| Sequence | ATGGCCAGGGGGGAGGGG | ||
| Applications | Specific imaging of ESCC tissues | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| ATCC ID | PDM-225 | Cell name | HCM-BROD-0020-C15 |
| Category | Human cells | Organism | Homo sapiens, human |
| Product type | N/A | Cell type | N/A |
| Morphology | N/A | Tissue | Esophagus |
| Disease | Cancer; Primary | Product format | Frozen |
| Antigen expression | N/A | Genes expressed | N/A |
| Cell description | N/A |
|
|
| Application(s) | 3D cell culture; Cancer research | ||
Activity data
 |
Interaction ID | 1154 |
| Target type | Cell | |
| Target unique ID | PDM-225 | |
| Activity | 265 nM | |
| Binding Conditions/Buffer | 4.5 g/L glucose, 5 mM MgCl2, 1 mg/mL bovine serum albumin (BSA) and 0.1 mg/mL yeast tRNA in 0.01 M PBS |
|
| Assay | Determination of the Kd of S3-2-3 |
|
| PubMed ID | 34105524 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_483 | DNA | ATTGGGAGGGATTGGGTGGG | |
| Apta_546 | DNA | CACGGCATGGTGGGCGTCGTG | |
| Apta_12 | DNA | TGAGGGGGTGGGTGGGACGGGTTGG | |
| Apta_27 | DNA | AGGGGGAGGGGTGGGGCCGGGCAGA | |
| Apta_28 | DNA | AGTGGGGGGGGTGGAGCCGGGTAGA | |
| Apta_208 | DNA | AGGAAGGGGTGGAAT | |
| Apta_1196 | DNA | GGGGGATGGGGG | |
| Apta_706 | DNA | CCGGCCAAGGGTGGGAGGGAGGGGGCCGG | |
| Apta_1019 | DNA | ATCCCTGCAGTTTGGTAGGGTGCAGG | |
| Apta_1193 | DNA | GGGTTGGAGGTGGAGGGGAGTTGAGG | |
| Apta_245 | DNA | ACAGGGGTGTGGGGACAGGGGTGTGGGG | |
| Apta_1195 | DNA | GGGGTTGGGGGGAGGCGGGGAATGGGGG | |
| Apta_679 | DNA | CAGGTGGCAGATCGGGTGTGGGTGGCCTGG | |
| Apta_925 | RNA | GCUCGGCCAGGUCGCGGGUGGAUGUGAGGG | |
| Apta_757 | DNA | GGTGGTGGTGGTTGTGGTGGTGG | |
| Apta_9 | DNA | TGAGGGGGCGGCGGGGCCGGGCAGG | |
| Apta_11 | DNA | AGAGGGGGGGGTCGGGGTGGGTCGC | |
| Apta_13 | DNA | AGGGGGGGGGGAGGGGTCGGGGTGG | |
| Apta_14 | DNA | AGCGGGGGGGGCTGGGCTGGGTGGG | |
| Apta_15 | DNA | TGAGGGGGGGGGAGGGCGGGGCTGC |
DEV TOOL
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