Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 1280
Aptamer sequence: CGACACCACACAGCAGTAAGCACTACAACATAGTGGTCTAGACTATCTCGGGCCGGTG
Target unique ID: 431734
| Aptamer ID | Aptamer descriptor | Target chemistry | Target name | Affinity | Binding Conditions/Buffer | PubMed ID |
|---|---|---|---|---|---|---|
| Apta_1218 | ATX4 | Molecule | Ethanone, 1-(9-azabicyclo(4.2.1)non-2-en-2-yl)-, (1R)- | 425.3 nM | 50 mM Tris, pH 7.5, 150 mM NaCl, 2 mM MgCl2 | 25594161 |
Structure information of aptamer
| Aptamer Sequence: | CGACACCACACAGCAGTAAGCACTACAACATAGTGGTCTAGACTATCTCGGGCCGGTG |
| The optimal secondary structure in dot-bracket notation: | ...((((.....((.....))((((.....))))((((((((...))).))))))))) |
| The centroid secondary structure in dot-bracket notation: | ...((((.....((.....))((((.....))))((((((((...))).))))))))) |
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
| Type | Detail | Type | Detail |
|---|---|---|---|
| Aptamer ID | Apta_1218 | Description | ATX4 |
| Aptamer chemistry | DNA | Length | 58 nt |
| GC content | 53.4% | Molecular weight | 17,829.46 Da |
| Molarity of 1 μg/μl solution | 56.09 μM | Number of G-quadruplexes | No QGRS found |
| G-Score | N/A | Function | Aptasensor |
| Sequence | CGACACCACACAGCAGTAAGCACTACAACATAGTGGTCTAGACTATCTCGGGCCGGTG | ||
| Applications | Aptasensor for neurotoxin anatoxin-a | ||
Target information
| Type | Detail | Type | Detail |
|---|---|---|---|
| PubChem ID | 431734 | Molecular name | Ethanone, 1-(9-azabicyclo(4.2.1)non-2-en-2-yl)-, (1R)- |
| Molecular formula | C10H15NO | Molecular weight | 165.23 |
| IUPAC name | 1-(9-azabicyclo[4.2.1]non-2-en-2-yl)ethanone | InChIKey | SGNXVBOIDPPRJJ-UHFFFAOYSA-N |
| LogP | 1.416 | Topological polar surface area | 29.1 |
| Hydrogen bond acceptor | 2 | Hydrogen bond donor | 1 |
Synonym(s): Anatoxin A; Anatoxin-a; (+)-Anatoxin; CHEMBL25619; CHEBI:2706; Ethanone, 1-(9-azabicyclo(4.2.1)non-2-en-2-yl)-, (1R)-; 2-acetyl-9-azabicyclo[4.2.1]non-2-ene; 1-(9-azabicyclo[4.2.1]non-2-en-2-yl)ethanone; AC1L8S0X; Anatoxin-A,(+); SureCN160708; 1-(9-azabicyclo[4.2.1]non-4-en-5-yl)ethanone; SCHEMBL160708; BDBM50023330; NCGC00162392-01; NCGC00162392-02; 2-Acetyl-9-azabicyclo[4.2.1]nona-2-ene; 2-acetyl-9-azabicyclo [4.2.1]non-2-ene; 1-(9-azabicyclo[4.2.1]non-2-en-2-yl)-ethanone; Q3303006; 1-(9-Aza-bicyclo[4.2.1]non-2-en-2-yl)-ethanone; (+/-)-2-ACETYL-9-AZABICYCLO[4.2.1]NON-2-ENEFUMARATE
Activity data
|
No relevant experimental diagram |
Interaction ID | 1280 |
| Target type | Molecule | |
| Target unique ID | 431734 | |
| Activity | 425.3 nM | |
| Binding Conditions/Buffer | 50 mM Tris, pH 7.5, 150 mM NaCl, 2 mM MgCl2 |
|
| Assay | N/A |
|
| PubMed ID | 25594161 |
Similar aptamers
| Aptamer ID | Aptamer chemistry | Sequence | Similarity |
|---|---|---|---|
| Apta_685 | DNA | GGGGCAACAAACACGGAAGAAAATGAATCTACATACGTGGACATATATCCTGCCGCGTG | |
| Apta_728 | DNA | CGACCCGGCACAAACCCAGAACCATATACACGATCATTAGTCTCCTGGGCCG | |
| Apta_686 | DNA | GGTCACCAACAACAGGGAGCGCTACGCGAAGGGTCAATGTGACGTCATGCGGATGTGTGG | |
| Apta_1227 | DNA | CACACCAAACACACAAGTGGACCCTGACGCATGGATAGGGTGACGGTATACGCGGGCATG | |
| Apta_992 | DNA | TCACTGACAGTAGGCCCATACGCACATTCAACAATCGGTAGTCCATACAACCGCGCCCCGTG | |
| Apta_405 | DNA | TCTAGCCCACTGCATAGAGGTAGCCACGTATGTGGGTGTTACCCATTCGTAGCTACCGGTG | |
| Apta_261 | DNA | TAAACCCCAAAACAGTGCAACTAGGTGTAGGTCCCGTGGT | |
| Apta_173 | DNA | AGCAGCACAGAGGTCAGATGGCAGGTTTCGACGTACAATGCTATGGAGGCTTTATGATCGCCTATGCGTGCTACCGTGAA | |
| Apta_175 | DNA | AGCAGCACAGAGGTCAGATGAGGACTGTCGATAAGTATAATGGCAAGTAGCTCGATACATCCTATGCGTGCTACCGTGAA | |
| Apta_663 | DNA | CACGCACAGAAGACACCTACAGGGCCAGATCACAATCGGTTAGTGAACTCGTACGGCGCG | |
| Apta_1233 | DNA | TCACGAGAGAGCGAGAGCGCCCCCCCACCACAGCCGTCACCACCCTATTCCTCTGCCGTTG | |
| Apta_228 | DNA | AGCAGCACAGAGGTCAGATGCGGCGCGGGGTCTTTTACAAATAGTTGTCCTAGCCACGCCTATGCGTGCTACCGTGAA | |
| Apta_104 | DNA | AGCAGCACAGAGGTCAGATGCAAACCACAGCCTGAGTGGTTAGCGTATGTCATTTACGGACCTATGCGTGCTACCGTGAA | |
| Apta_107 | DNA | AGCAGCACAGAGGTCAGATGTTCATTTCAGTTGACCGATAGCATTGAGCAATGATCTATTCCTATGCGTGCTACCGTGAA | |
| Apta_108 | DNA | AGCAGCACAGAGGTCAGATGCTTTGCCACGGCAACGTCCCAAAACTAATGGTAACTATACCCTATGCGTGCTACCGTGAA | |
| Apta_104 | DNA | AGCAGCACAGAGGTCAGATGCAAACCACAGCCTGAGTGGTTAGCGTATGTCATTTACGGACCTATGCGTGCTACCGTGAA | |
| Apta_107 | DNA | AGCAGCACAGAGGTCAGATGTTCATTTCAGTTGACCGATAGCATTGAGCAATGATCTATTCCTATGCGTGCTACCGTGAA | |
| Apta_108 | DNA | AGCAGCACAGAGGTCAGATGCTTTGCCACGGCAACGTCCCAAAACTAATGGTAACTATACCCTATGCGTGCTACCGTGAA | |
| Apta_226 | DNA | GGGAGATCACTTACGGCACCGTATAGTCGTACATGAACGAGTGTGAGTGTTAAGCCTTTGGCGACAGGGCTCGGAACC | |
| Apta_232 | DNA | AGCAGCACAGAGGTCAGATGCTATGAGCAGATCCGATAGAAAGTTAATGCCCTAGAACATCCTATGCGTGCTACCGTGAA |
DEV TOOL
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