AptaDB: Result

Interaction ID: 1247

Aptamer sequence: CAGGGGGTTTTGGTGGGGGGGGCTGGGTTGTCTTGGGGGTGGGCT

Target unique ID: Q06124

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_1185	SH-HJ24	Protein	PTN11_HUMAN	N/A	N/A	22924632

Aptamer Sequence:	CAGGGGGTTTTGGTGGGGGGGGCTGGGTTGTCTTGGGGGTGGGCT
The optimal secondary structure in dot-bracket notation:	(((((...((((((.......))))))...)))))..........
The centroid secondary structure in dot-bracket notation:	(((((...((((((.......))))))...)))))..........

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_1185	Description	SH-HJ24
Aptamer chemistry	DNA	Length	45 nt
GC content	68.9%	Molecular weight	14,251.04 Da
Molarity of 1 μg/μl solution	70.17 μM	Number of G-quadruplexes	4
G-Score	76	Function	Targeted binding
Sequence	CAGGGGGTTTTGGTGGGGGGGGCTGGGTTGTCTTGGGGGTGGGCT
Applications	Binding to shp2

Type	Detail	Type	Detail
Uniprot ID	Q06124	Protein name	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene name(s)	PTPN11 PTP2C SHPTP2	Organism	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Status	reviewed in uniprot database	Length	593
Mass	68,011	Activity regulation	N/A
Involvement in disease	LEOPARD syndrome 1 (LPRD1)	Catalytic activity	Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
PDB ID(s)	2SHP;3B7O;3MOW;3O5X;3TKZ;3TL0;3ZM0;3ZM1;3ZM2;3ZM3;4DGP;4DGX;4GWF;4H1O;4H34;4JE4;4JEG;4JMG;4NWF;4NWG;4OHD;4OHE;4OHH;4OHI;4OHL;4PVG;4QSY;4RDD;5BK8;5DF6;5EHP;5EHR;5I6V;5IBM;5IBS;5X7B;5X94;5XZR;6ATD;6BMR;6BMU;6BMV;6BMW;6BMX;6BMY;6BN5;6CMP;6CMQ;6CMR;6CMS;6CRF;6CRG;6MD7;6MD9;6MDA;6MDB;6MDC;6MDD;6R5G;6WU8;7EMN;7JVM;7JVN;7R75;7R7D;7R7I;7R7L;7RCT;7VXG;
Function	Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.

	Interaction ID	1247
	Target type	Protein
	Target unique ID	Q06124
	Activity	N/A
	Binding Conditions/Buffer	N/A
	Assay	Typical force curves of dual-labeled G-quadruplex in solution
	PubMed ID	22924632

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_1186	DNA	AGGGGGTTTTGGTGGGGGGGGCTGGGTTGTCTTGGGGGTGGGCT	97.78%
Apta_869	DNA	ACTAGGACGCTTGGGAGGGGGGGTGGGGTGTCCGGTCGCG	60.00%
Apta_1014	DNA	TGGGGGTTGGGTGGATAGGCTGGCGTCGGGGCAGGTCAGT	60.00%
Apta_46	DNA	CGGGTGGGAGTTGTGGGGGGGGGTGGGAGGGTT	57.78%
Apta_264	DNA	GGCGTTGTCGGGCGCAGGTGTAGGCCTCGTGGTGGTGGGT	57.78%
Apta_565	DNA	GCGGGGTTGGGCGGGTGGGTTCGCTGGGCAGGGGGCGAGTG	57.78%
Apta_223	DNA	CATTGAGATAGCTAGTTGTAGCTGCGTCATAGGCTGGGTTGGGTCTAGTGGTTGGGTGTG	56.67%
Apta_41	DNA	CGGTCGCTCCGTGTGGCTTGGGTTGGGTGTGGCAGTGAC	55.56%
Apta_263	DNA	AGAGGGGAGGGTCGGGTATCGGCGTGTTCGGGGGATCTGC	55.56%
Apta_482	DNA	AGCAAGGTTTGGTGTTGGTTGGTTGCTGGTTTTGGTTTC	55.56%
Apta_493	DNA	GGGGTGGTGGGTTCTTTTTGTGGTATTGGTGTGGGGGGCA	55.56%
Apta_1085	DNA	TGGGGTGGTGGTGTGGGTGGGGGTTTGTTC	55.56%
Apta_1188	DNA	CGGGCGGGGCGTGGGGTGTTGGAGTGGAGGGCGGGGCGGC	55.56%
Apta_1189	DNA	GCGGGCGGGGGGAGGGCGGCCGTGGGCTGCGAGTGGGAGG	55.56%
Apta_1195	DNA	GGGGTTGGGGGGAGGCGGGGAATGGGGG	55.56%
Apta_1237	DNA	GGGGTTGTGTGGGGAGTTTGTCCTGTTGTG	55.56%
Apta_617	DNA	CAATGGGGTCGGGCGGGCCGGGTGTCATGGTGGACGGAGATGGGACGTAGAGGGCGGT	55.17%
Apta_76	DNA	CAGCGCTAGGGCTTTTAGCGTAATGGGTAGGGTGGTGCGGTGCAGATATCGGAATTGGTG	55.00%
Apta_609	DNA	GCTGCGAGGTGGGTGGGTGGGAGCAATTGGTCCTCGCTTAGCTTCTACGGTGGGCTATCT	55.00%
Apta_610	DNA	GCTGTGAGGTGGGTGGGTGGGAGCAATTGGTCCTCGCTTAGCTTCTACGGTGGGCTATCT	55.00%

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