Aptamer-target interaction descriptor
Aptamer-target interaction information
Interaction ID: 882
Aptamer sequence: GTTCGTGGTGTGCTGGATGTCGGAGATGGTCCGCTTCGTTCAACTACTACGCATTTTGACACATCCAGCAGCACGA
Target unique ID: CRL-2945
Aptamer ID Aptamer descriptor Target chemistry Target name Affinity Binding Conditions/Buffer PubMed ID
Apta_798 Apoc34 Cell Primary serous ovarian cancer (pSOC) cells 3.42 μM PBS 33787226
Structure information of aptamer
Aptamer Sequence: GTTCGTGGTGTGCTGGATGTCGGAGATGGTCCGCTTCGTTCAACTACTACGCATTTTGACACATCCAGCAGCACGA
The optimal secondary structure in dot-bracket notation: ..(((((...((((((((((..((((((.......................))))))...)))))))))).)))))
The centroid secondary structure in dot-bracket notation: ..(((((...((((((((((..((((((.......................))))))...)))))))))).)))))
The MFE structure
The Centroid structure
The mountain plot representation
Aptamer information
Type Detail Type Detail
Aptamer ID Apta_798 Description Apoc34
Aptamer chemistry DNA Length 76 nt
GC content 52.6% Molecular weight 23,431.98 Da
Molarity of 1 μg/μl solution 42.68 μM Number of G-quadruplexes 2
G-Score 19 Function Targeted therapy
Sequence GTTCGTGGTGTGCTGGATGTCGGAGATGGTCCGCTTCGTTCAACTACTACGCATTTTGACACATCCAGCAGCACGA
Applications Molecular tools for rapid intraoperative diagnosis and In vivo imaging of serous ovarian cancer
Target information
Type Detail Type Detail
ATCC ID CRL-2945 Cell name Primary serous ovarian cancer (pSOC) cells
Category Human cells Organism Homo sapiens, human
Product type N/A Cell type N/A
Morphology epithelial-like Tissue Ovary
Disease Carcinoma Product format Frozen
Antigen expression Cytokeratin 7 (CK-7), positive; calretinin, positive Genes expressed p53; cytokeratin 7 (CK-7) positive; calretinin positive; Wilms' tumor protein (WT) positive; BRCA1 negative
Cell description N/A
Application(s) 3D cell culture; Cancer research
Activity data

No relevant experimental diagram

 Interaction ID 882
Target type Cell
Target unique ID CRL-2945
Activity 3.42 μM
Binding Conditions/Buffer

PBS
Assay

N/A
PubMed ID 33787226
Similar aptamers
Aptamer ID Aptamer chemistry Sequence Similarity
Apta_799 DNA GTTCGTGGTGTGCTGGATGTCCCGTGCACGGCGCCACGTTTTCCTCTCATCCCCGATGACACATCCAGCAGCACGA 73.68%
Apta_797 DNA GTTCGTGGTGTGCTGGATGTCACCTCCACTCACCACCTCTTCTCCGCTCCTCGTCATGACACATCCAGCAGCACGA 71.05%
Apta_726 DNA TACCAGTGCGATGCTCAGGCCGATGTCAACTTTTTCTAACTCACTGGTTTTGCCTGACGCATTCGGTTGAC 53.95%
Apta_807 DNA GGGTCTTCCTGGACTGTCGAAAATTCAGTATCGGGAGGTTACGTATTTGGTTTATAGATAGTAA 53.95%
Apta_1273 DNA TCCCTCCTGTTGGTTTGGGATGGTGGCGACTATCTGATTGTTTGACTCCCCGTAGGGG 53.95%
Apta_435 DNA CCTTCGTTGTCTGCCTTCGTAGGACCGCAGACATCGACGCAGGGAAATTCCGCAAGTCCAGCCAAATGCCACCCTTCAGAATTCGCACCA 53.33%
Apta_311 DNA GTGGGGTTGGGTGGGTTTGGGTTATGGGCGCTCCGGCCCGGCGTCTTGCGTCCCTTCCAT 52.63%
Apta_796 DNA GTGCTGGATGTCACCTCCACTCACCACCTCTTCTCCGCTCCTCGTCATGACACATCCAG 52.63%
Apta_321 DNA AACCGCCCAAATCCCTAAGAGTCGGACTGCAACCTATGCTATCGTTGATGTCTGTCCAAGCAACACAGACACACTACACACGCACA 52.33%
Apta_466 DNA AGCTGACACAGCAGGTTGGTGGGGGTGGCTCACATCATGGTAGAATGACTGAACAGCGTTGATTAAAAGGCACGAGTCGAGCAATCTCGAAAT 51.61%
Apta_933 DNA GACGCTTACTCAGGTGTGACTCGGGGTGTAGCTCGTTATGATTCGGACAAGACTTACCTTGCGCCTCTGGGATCGAAGGACGCAGATGAAGTCTC 51.58%
Apta_310 DNA GCGCCAGCTTTGCTGATGGGTGGCCACCCTTGCCCTGGGTTTGAATTTCGATCCTATCG 51.32%
Apta_558 DNA CCGGTGGGTGGTCAGGTGGGATAGCGTTCCGCGTATGGCCCAGCGCATCACGGGTTCGCACCA 51.32%
Apta_609 DNA GCTGCGAGGTGGGTGGGTGGGAGCAATTGGTCCTCGCTTAGCTTCTACGGTGGGCTATCT 51.32%
Apta_611 DNA GCTGCGAGGTGGGTGGGTGGGAGCAATTGGTCCTTGCTTAGCTTCTACGGTGGGCTATCT 51.32%
Apta_978 DNA GGCGATGAGAACGGGAGCCTGATGATACACACGAGCGATCGCTCATAAAAGCCGTGCCCG 51.32%
Apta_979 DNA ATGAGTAGTGCGGAGGGATGTGAATACTGACGCGGTCATAGTCGCTGTTGTACCATTGA 51.32%
Apta_981 DNA TATGGAGAGTCAATGAGTACAGTCTCGTCTCAATAACGGAGCCTCGTCCGTGCCCCCG 51.32%
Apta_1108 DNA GTGCTTAGGTGCAGAACGCACACACGCTCGGTATGACGTGTTCGCTACGGTATAATTGCAGGCGCGAGCACAACAG 51.32%
Apta_1111 DNA GTGCGTCGCATGATCGCGATTAGTGCGACCATGTACGATTCTCACGACAACGACACTGTACTTGAGGACTGTCTCC 51.32%

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AptaDB is an online database we developed to integrate comprehensive information about aptamer.
The detail of this database is described here:

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