AptaDB: Result

Interaction ID: 1213

Aptamer sequence: TATTTTTATATTTGTTTGACAGTCGCTTGCTTGTGTAGGCGTT

Target unique ID: P03524

Aptamer ID	Aptamer descriptor	Target chemistry	Target name	Affinity	Binding Conditions/Buffer	PubMed ID
Apta_1153	GE54	Protein	GLYCO_RABVE	307 nM	4.5 g/l glucose and 5 mmol/l MgCl2 in Dulbecco’s PBS	24486485

Aptamer Sequence:	TATTTTTATATTTGTTTGACAGTCGCTTGCTTGTGTAGGCGTT
The optimal secondary structure in dot-bracket notation:	.......................(((((((....)))))))..
The centroid secondary structure in dot-bracket notation:	.......................(((((((....)))))))..

The MFE structure

The Centroid structure

The mountain plot representation

Type	Detail	Type	Detail
Aptamer ID	Apta_1153	Description	GE54
Aptamer chemistry	DNA	Length	43 nt
GC content	34.9%	Molecular weight	13,247.50 Da
Molarity of 1 μg/μl solution	75.49 μM	Number of G-quadruplexes	No QGRS found
G-Score	N/A	Function	Targeted therapy
Sequence	TATTTTTATATTTGTTTGACAGTCGCTTGCTTGTGTAGGCGTT
Applications	Inhibit the replication of RABV

Type	Detail	Type	Detail
Uniprot ID	P03524	Protein name	Glycoprotein
Gene name(s)	G	Organism	Glycoprotein
Status	reviewed in uniprot database	Length	524
Mass	58,658	Activity regulation	N/A
Involvement in disease	N/A	Catalytic activity	N/A
PDB ID(s)	3NFK;
Function	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane.

	Interaction ID	1213
	Target type	Protein
	Target unique ID	P03524
	Activity	307 nM
	Binding Conditions/Buffer	4.5 g/l glucose and 5 mmol/l MgCl2 in Dulbecco’s PBS
	Assay	The inhibition of non-RABV viral infections by aptamers in vitro
	PubMed ID	24486485

Aptamer ID	Aptamer chemistry	Sequence	Similarity
Apta_1155	DNA	TAGTTTTATTTGTTCATTTTGTGTATTGTTTTGA	55.81%
Apta_1045	DNA	GGTGCTCAGGGAACTGTCTGAGGGATCAGGCTTAAGCCTGTCGAGCAGTT	54.00%
Apta_1026	DNA	GGGGGGTGTATCGTTGACGAGTTGCGCGTGCGTCTCGTG	53.49%
Apta_1243	DNA	GGTGTTGTTGTTGGCTAGTTTGTTGTGGGC	53.49%
Apta_1278	DNA	CCATGATTCAACTTTACTGGTCTTGTCTTGGCTAGTCGTGTGTCATTCCCTAAGG	52.73%
Apta_737	DNA	ATCGTCTGCTCCGTCCAATAGTGCATTGAAACTTCTGCATCCTCGTTTGGTGTGAGGTCGTGC	52.38%
Apta_223	DNA	CATTGAGATAGCTAGTTGTAGCTGCGTCATAGGCTGGGTTGGGTCTAGTGGTTGGGTGTG	51.67%
Apta_738	DNA	ATCGTCTGCTCCGTCCAATACCTGCATATACACTTTGCATGTGGTTTGGTGTGAGGTCGTGC	51.61%
Apta_240	DNA	TTTTTAATTAAAGCTCGCCATCAAATAGCTTT	51.16%
Apta_364	DNA	TATGGTATGCTGTGTGGTATGGGGTGGCGTGCTCT	51.16%
Apta_476	DNA	CCTATCTTATTCGTTGCGGACTCCCCGGTCGGTATGTATG	51.16%
Apta_482	DNA	AGCAAGGTTTGGTGTTGGTTGGTTGCTGGTTTTGGTTTC	51.16%
Apta_733	DNA	TAGGCAGTGGTTTGACGTCCGCATGTTGGGAATAGCCACGCCT	51.16%
Apta_912	DNA	TAGTATGGACTTGTCTTCTTGTCAGAGTCTGGCAGCACGT	51.16%
Apta_913	DNA	GGCACTTGTTTGCTCGAACGATGGTTTGTGCTTTTGTGTT	51.16%
Apta_1176	DNA	AGTATGATATCGGTGTTTATGGTGTCTGTCTTCATACT	51.16%
Apta_1238	DNA	GGTTTTGTGTTTGTGTTTTGTGGTTGTTGT	51.16%
Apta_1245	DNA	AGTGTGAAGTGGTGTGTGTTGTTGTTTGTC	51.16%
Apta_752	DNA	GCTATCTTATGGAAATTTCGTGTAGGGTTTGGTGTGGCGGGGCTA	51.11%
Apta_1154	DNA	TTAATTTTTTGATCTTTGATTGTTTTATTTTTTTTATTGTTTGTG	51.11%

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