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Paper-scoped peptide mentionSequence reported

pep1

PMC9952496::PEP000001

Source publication

A Novel Strategy for the Design of Aurein 1.2 Analogs with Enhanced Bioactivities by Conjunction of Cell-Penetrating Regions.

Antibiotics · 2023

DOI 10.3390/antibiotics12020412 PMC9952496 PMID 36830322

Sequence status: reported
Standardization: Sequence ready
Source location: table
Activity records: 28

Sequence evidence

Reported molecular identity

GLFDIIKKIAESF

Table 1: aurein 1.2 GLFDIIKKIAESF-NH2

Resolved peptide links

PEPDIA-PLP-003592 CTPDB_P035993

Experimental observations

Records linked to this mention

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MIC 8 μM against S. aureus (ATCC CRM 6538)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MIC
Value: 8.0 μM
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MBC 8 μM against S. aureus (ATCC CRM 6538)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MBC
Value: 8.0 μM
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MIC 16 μM against MRSA (ATCC 12493)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MIC
Value: 16.0 μM
Target: MRSA
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MBC 16 μM against MRSA (ATCC 12493)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MBC
Value: 16.0 μM
Target: MRSA
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MIC 32 μM against E. faecalis (NCTC 12697)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MIC
Value: 32.0 μM
Target: Enterococcus faecalis
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MBC 32 μM against E. faecalis (NCTC 12697)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MBC
Value: 32.0 μM
Target: Enterococcus faecalis
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MIC 16 μM against E. coli (NCTC 8739)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MIC
Value: 16.0 μM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MBC 16 μM against E. coli (NCTC 8739)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MBC
Value: 16.0 μM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MIC 64 μM against P. aeruginosa (ATCC 9027)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MIC
Value: 64.0 μM
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MBC 128 μM against P. aeruginosa (ATCC 9027)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MBC
Value: 128.0 μM
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MIC 64 μM against K. pneumoniae (ATCC 43816)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MIC
Value: 64.0 μM
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MBC 64 μM against K. pneumoniae (ATCC 43816)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MBC
Value: 64.0 μM
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBIC 16 μM against S. aureus (ATCC CRM 6538)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: 16.0 μM
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBEC 64 μM against S. aureus (ATCC CRM 6538)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: 64.0 μM
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBIC 16 μM against MRSA (ATCC 12493)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: 16.0 μM
Target: MRSA
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBEC 64 μM against MRSA (ATCC 12493)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: 64.0 μM
Target: MRSA
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBIC 32 μM against E. faecalis (NCTC 12697)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: 32.0 μM
Target: Enterococcus faecalis
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBEC >128 μM against E. faecalis (NCTC 12697)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: >128 µM
Target: Enterococcus faecalis
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBIC 64 μM against E. coli (NCTC 8739)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: 64.0 μM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBEC 64 μM against E. coli (NCTC 8739)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: 64.0 μM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBIC 64 μM against P. aeruginosa (ATCC 9027)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: 64.0 μM
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBEC >128 μM against P. aeruginosa (ATCC 9027)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: >128 µM
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBIC 128 μM against K. pneumoniae (ATCC 43816)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: 128.0 μM
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBEC >128 μM against K. pneumoniae (ATCC 43816)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: >128 µM
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AnticancerPositive observation

Table 4: aurein 1.2 IC50 26.9 ± 0.80 μM against H838

Mention PMC9952496::PEP000001PMC9952496table

Measure: other
Value: 26.9 μM
Target: H838
Assay: Not reported by source

Source publication

AnticancerPositive observation

Table 4: aurein 1.2 IC50 38.4 ± 0.24 μM against U251MG

Mention PMC9952496::PEP000001PMC9952496table

Measure: other
Value: 38.4 μM
Target: U251MG
Assay: Not reported by source

Source publication

AnticancerPositive observation

Table 4: aurein 1.2 IC50 25.9 ± 0.79 μM against MCF-7

Mention PMC9952496::PEP000001PMC9952496table

Measure: other
Value: 25.9 μM
Target: MCF-7
Assay: Not reported by source

Source publication

ToxicityHemolyticPositive observation

Table 5: aurein 1.2 hemolysis 20.56% at MIC for E. coli (16 μM)

Mention PMC9952496::PEP000001PMC9952496table

Measure: hemolysis
Value: 20.56 %
Target: Horse erythrocytes
Assay: Not reported by source

Source publication

Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.