Back to Primary literature

Primary-literature peptidemedium evidence

PEPDIA-PLP-003592

pep1

Aliases: Aurein, pep1

Normalized sequence

GLFDIIKKIAESF

13 amino acids

Release PepDiana-V1-20260620

29

Activity records

2

Source papers

29

Positive

0

Negative / threshold

Cross-layer links

Related Integrated records

PEPDIA-INT-035993

Versioned scientific descriptors

Physicochemical properties and standard representations

not calculated

Reported properties

No separate physicochemical property was reported in the primary-literature identity record. PepDiana release values are shown as computed properties.

Computed properties

physchem-20260620

Molecular weight

Not calculated

Molecular formula

Not calculated

Theoretical pI

Not calculated

Net charge at pH 7

Not calculated

GRAVY

Not calculated

Instability index

Not calculated

Aromaticity

Not calculated

Topological polar surface area

Not calculated

cLogP

Not calculated

Hydrogen-bond donors

Not calculated

Hydrogen-bond acceptors

Not calculated

Rotatable bonds

Not calculated

Method: Not recorded

Tool: Not recorded

Calculated: Not recorded

Sequence representations

representations-20260620

ProForma 2.0

Not calculated for this record

HELM 2.0

Not calculated for this record

Canonical SMILES

Not calculated for this record

Isomeric SMILES

Not calculated for this record

Paper-level observations

Experimental evidence grouped by activity

Antimicrobial 24 records

PMC9952496

24 observations

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MIC 8 μM against S. aureus (ATCC CRM 6538)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MIC
Value: 8.0 μM
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MBC 8 μM against S. aureus (ATCC CRM 6538)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MBC
Value: 8.0 μM
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MIC 16 μM against MRSA (ATCC 12493)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MIC
Value: 16.0 μM
Target: MRSA
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MBC 16 μM against MRSA (ATCC 12493)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MBC
Value: 16.0 μM
Target: MRSA
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MIC 32 μM against E. faecalis (NCTC 12697)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MIC
Value: 32.0 μM
Target: Enterococcus faecalis
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MBC 32 μM against E. faecalis (NCTC 12697)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MBC
Value: 32.0 μM
Target: Enterococcus faecalis
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MIC 16 μM against E. coli (NCTC 8739)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MIC
Value: 16.0 μM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MBC 16 μM against E. coli (NCTC 8739)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MBC
Value: 16.0 μM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MIC 64 μM against P. aeruginosa (ATCC 9027)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MIC
Value: 64.0 μM
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MBC 128 μM against P. aeruginosa (ATCC 9027)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MBC
Value: 128.0 μM
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MIC 64 μM against K. pneumoniae (ATCC 43816)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MIC
Value: 64.0 μM
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAntibacterialPositive observation

Table 2: aurein 1.2 MBC 64 μM against K. pneumoniae (ATCC 43816)

Mention PMC9952496::PEP000001PMC9952496table

Measure: MBC
Value: 64.0 μM
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBIC 16 μM against S. aureus (ATCC CRM 6538)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: 16.0 μM
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBEC 64 μM against S. aureus (ATCC CRM 6538)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: 64.0 μM
Target: Staphylococcus aureus
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBIC 16 μM against MRSA (ATCC 12493)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: 16.0 μM
Target: MRSA
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBEC 64 μM against MRSA (ATCC 12493)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: 64.0 μM
Target: MRSA
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBIC 32 μM against E. faecalis (NCTC 12697)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: 32.0 μM
Target: Enterococcus faecalis
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBEC >128 μM against E. faecalis (NCTC 12697)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: >128 µM
Target: Enterococcus faecalis
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBIC 64 μM against E. coli (NCTC 8739)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: 64.0 μM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBEC 64 μM against E. coli (NCTC 8739)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: 64.0 μM
Target: Escherichia coli
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBIC 64 μM against P. aeruginosa (ATCC 9027)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: 64.0 μM
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBEC >128 μM against P. aeruginosa (ATCC 9027)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: >128 µM
Target: Pseudomonas aeruginosa
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBIC 128 μM against K. pneumoniae (ATCC 43816)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: 128.0 μM
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

AntimicrobialAnti-BiofilmPositive observation

Table 3: aurein 1.2 MBEC >128 μM against K. pneumoniae (ATCC 43816)

Mention PMC9952496::PEP000001PMC9952496table

Measure: biofilm_inhibition
Value: >128 µM
Target: Klebsiella pneumoniae
Assay: Not reported by source

Source publication

Anticancer 3 records

PMC9952496

3 observations

AnticancerPositive observation

Table 4: aurein 1.2 IC50 26.9 ± 0.80 μM against H838

Mention PMC9952496::PEP000001PMC9952496table

Measure: other
Value: 26.9 μM
Target: H838
Assay: Not reported by source

Source publication

AnticancerPositive observation

Table 4: aurein 1.2 IC50 38.4 ± 0.24 μM against U251MG

Mention PMC9952496::PEP000001PMC9952496table

Measure: other
Value: 38.4 μM
Target: U251MG
Assay: Not reported by source

Source publication

AnticancerPositive observation

Table 4: aurein 1.2 IC50 25.9 ± 0.79 μM against MCF-7

Mention PMC9952496::PEP000001PMC9952496table

Measure: other
Value: 25.9 μM
Target: MCF-7
Assay: Not reported by source

Source publication

Toxicity 2 records

PMC11909139

1 observations

ToxicityHemolyticPositive observation

Table 6: Aurein PROB 0.779

Mention PMC11909139::PEP000003PMC11909139table

Measure: other
Value: PROB 0.779
Target: Not reported by source
Assay: Not reported by source

Source publication

PMC9952496

1 observations

ToxicityHemolyticPositive observation

Table 5: aurein 1.2 hemolysis 20.56% at MIC for E. coli (16 μM)

Mention PMC9952496::PEP000001PMC9952496table

Measure: hemolysis
Value: 20.56 %
Target: Horse erythrocytes
Assay: Not reported by source

Source publication

Citation and release provenance

Cite this identity as PepDiana record PEPDIA-PLP-003592, release PepDiana-V1-20260620. Experimental observations retain their paper, mention, and activity-record identifiers.

Record updated: 2026-06-22T07:14:26.229247+00:00