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PEPDIA-INT-035993

Gold

Aurein-1.2

85

Quality

7

Source DBs

126

Activities

24

Source refs

14

Literature

1

Patents

Integrated record

Sequence and molecular profile

GLFDIIKKIAESF
Indexed sequence13 aa
1GLFDIIKKIAESF

Length

13

Molecular weight

1480.77 Da

Formula

C71H113N15O19

Structure type

Linear

Synthesis

Ribosomal

Chirality

L

Family

-

Gene

-

Residue composition

I
3
F
2
K
2
G
1
L
1
D
1
A
1
E
1
S
1

Physicochemical profile

Hydrophobic7

Membrane affinity proxy

Polar1

Solubility proxy

Charged4

Net charge proxy +0

Aromatic2

Binding interaction proxy

Versioned scientific descriptors

Physicochemical properties and standard representations

calculated sequence and structure

Reported properties

Legacy compatibility fields are materialized from the versioned PepDiana computed release; no separate source-reported property is available.

Computed properties

physchem-20260620

Molecular weight

1480.7458 Da

Molecular formula

C71H113N15O19

Theoretical pI

6.069

Net charge at pH 7

-0.238

GRAVY

0.6692

Instability index

20.4769

Aromaticity

0.1538

Topological polar surface area

559.39 Ų

cLogP

-1.8732

Hydrogen-bond donors

19

Hydrogen-bond acceptors

19

Rotatable bonds

51

Method: PepDiana sequence/structure descriptor pipeline

Tool: Biopython+RDKit · Biopython 1.85; RDKit 2024.09.6

Calculated: 2026-06-20T11:01:38.358971+00:00

Assumptions: ph=7; termini=free N-terminus and free C-terminus for simple linear peptides; stereochemistry=standard L-amino acids; smiles_length_limit=200

Sequence representations

representations-20260620 · RDKit 2024.09.6

ProForma 2.0

validated simple linear

GLFDIIKKIAESF

HELM 2.0

validated simple linear

PEPTIDE1{G.L.F.D.I.I.K.K.I.A.E.S.F}$$$$V2.0

Canonical SMILES

validated

CCC(C)C(NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(NC(=O)C(CC(=O)O)NC(=O)C(Cc1ccccc1)NC(=O)C(CC(C)C)NC(=O)CN)C(C)CC)C(C)CC)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(CO)C(=O)NC(Cc1ccccc1)C(=O)O

Isomeric SMILES

validated

CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)O

Follow-up research

External analysis tools

Run BLASTPSearch similar protein or peptide sequences at NCBI.Search UniProtLook for related UniProtKB entries using the sequence.Search PubMedFind literature context for this peptide record.Search PubChemOpen chemistry search with the canonical SMILES string.

Links open third-party resources with the current PepDiana sequence, record name, or chemistry notation as the initial query.

Research workflow

Citation and local history

BibTeX

@misc{PEPDIA-INT-035993,
  title = {Aurein-1.2},
  author = {{PepDiana Consortium}},
  year = {2026},
  howpublished = {PepDiana Multifunctional Peptide Database},
  url = {http://127.0.0.1:3004/peptides/PEPDIA-INT-035993},
  note = {Accessed from local PepDiana development build}
}

APA-style note

Aurein-1.2. (2026). PepDiana record PEPDIA-INT-035993. PepDiana Multifunctional Peptide Database. http://127.0.0.1:3004/peptides/PEPDIA-INT-035993

This record is saved to local recent-view history so it can reappear on the peptide browser page.

Integrated source-database annotations

Biological activity (126 records)

Stable recordActivitySubtypeValueTargetAssay methodSource
CTPDB_P035993_ACT_apd_0000AntimicrobialAnti-Gram+Not available in the current structured importUnknownNot reported by sourceAP00013apd / linked
CTPDB_P035993_ACT_apd_0001AntimicrobialAntifungalNot available in the current structured importUnknownNot reported by sourceAP00013apd / linked
CTPDB_P035993_ACT_apd_0003Anticancer-Not available in the current structured importUnknownNot reported by sourceAP00013apd / linked
CTPDB_P035993_ACT_camp_0007AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourceCAMPSQ10450camp / linked
CTPDB_P035993_ACT_camp_0008AntimicrobialAnti-Gram+Not available in the current structured importUnknownNot reported by sourceCAMPSQ10450camp / linked
CTPDB_P035993_ACT_camp_0009AntimicrobialAnti-Gram-Not available in the current structured importUnknownNot reported by sourceCAMPSQ10450camp / linked
CTPDB_P035993_ACT_camp_0010AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourceCAMPSQ11793camp / linked
CTPDB_P035993_ACT_camp_0011AntimicrobialAnti-Gram-Not available in the current structured importUnknownNot reported by sourceCAMPSQ11793camp / linked
CTPDB_P035993_ACT_camp_0012AntimicrobialAntifungalNot available in the current structured importUnknownNot reported by sourceCAMPSQ13624camp / linked
CTPDB_P035993_ACT_camp_0004AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourceCAMPSQ228camp / linked
CTPDB_P035993_ACT_camp_0005AntimicrobialAnti-Gram+Not available in the current structured importUnknownNot reported by sourceCAMPSQ228camp / linked
CTPDB_P035993_ACT_camp_0006AntimicrobialAnti-Gram-Not available in the current structured importUnknownNot reported by sourceCAMPSQ228camp / linked
CTPDB_P035993_ACT_cancerppd_0013AnticancerAnticancerNot available in the current structured importUnknownNot Available1252cancerppd / linked
CTPDB_P035993_ACT_cancerppd_0014Antimicrobial-Not available in the current structured importUnknownNot Available1252cancerppd / linked
CTPDB_P035993_ACT_cancerppd_0015AnticancerAnticancerNot available in the current structured importUnknownNot Available1253cancerppd / linked
CTPDB_P035993_ACT_cancerppd_0016Antimicrobial-Not available in the current structured importUnknownNot Available1253cancerppd / linked
CTPDB_P035993_ACT_cancerppd_0017AnticancerAnticancerNot available in the current structured importUnknownNot Available1254cancerppd / linked
CTPDB_P035993_ACT_cancerppd_0018Antimicrobial-Not available in the current structured importUnknownNot Available1254cancerppd / linked
CTPDB_P035993_ACT_cancerppd_0019AnticancerAnticancerNot available in the current structured importUnknownNot Available1255cancerppd / linked
CTPDB_P035993_ACT_cancerppd_0020Antimicrobial-Not available in the current structured importUnknownNot Available1255cancerppd / linked
CTPDB_P035993_ACT_cancerppd_0021AnticancerAnticancerNot available in the current structured importUnknownNot Available1256cancerppd / linked
CTPDB_P035993_ACT_cancerppd_0022Antimicrobial-Not available in the current structured importUnknownNot Available1256cancerppd / linked
CTPDB_P035993_ACT_cancerppd_0023AnticancerAnticancerNot available in the current structured importUnknownNot Available1257cancerppd / linked
CTPDB_P035993_ACT_cancerppd_0024Antimicrobial-Not available in the current structured importUnknownNot Available1257cancerppd / linked
CTPDB_P035993_ACT_cancerppd_0025AnticancerAnticancerNot available in the current structured importUnknownNot Available1258cancerppd / linked
CTPDB_P035993_ACT_cancerppd_0026Antimicrobial-Not available in the current structured importUnknownNot Available1258cancerppd / linked
CTPDB_P035993_ACT_cancerppd_0027AnticancerAnticancerNot available in the current structured importUnknownNot Available1259cancerppd / linked
CTPDB_P035993_ACT_cancerppd_0028Antimicrobial-Not available in the current structured importUnknownNot Available1259cancerppd / linked
CTPDB_P035993_ACT_cancerppd_0029AnticancerAnticancerNot available in the current structured importUnknownNot Available1260cancerppd / linked
CTPDB_P035993_ACT_cancerppd_0030Antimicrobial-Not available in the current structured importUnknownNot Available1260cancerppd / linked
CTPDB_P035993_ACT_dbaasp_0086Antimicrobial-15 µMStaphylococcus aureus ATCC 29213Not reported by sourceDBAASPS_10333_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0087Antimicrobial-125 µMStaphylococcus aureus ATCC 29213Not reported by sourceDBAASPS_10333_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0088Antimicrobial-120 µMEscherichia coli MG1655Not reported by sourceDBAASPS_10333_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0089Antimicrobial-250 µMEscherichia coli MG1655Not reported by sourceDBAASPS_10333_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0090Antimicrobial-8 µMStaphylococcus aureus ATCC 29213Not reported by sourceDBAASPS_10334_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0091Antimicrobial-37.5 µMStaphylococcus aureus ATCC 29213Not reported by sourceDBAASPS_10334_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0092Antimicrobial-120 µMEscherichia coli MG1655Not reported by sourceDBAASPS_10334_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0093Antimicrobial-250 µMEscherichia coli MG1655Not reported by sourceDBAASPS_10334_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0094Antimicrobial->1000 µg/mlStaphylococcus aureus ATCC 25923Not reported by sourceDBAASPS_13669_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0095Antimicrobial-254±3.4 µg/mlBacillus subtilis ATCC 6051Not reported by sourceDBAASPS_13669_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0096Antimicrobial-125±0.0 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_13669_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0097Antimicrobial->1000 µg/mlPseudomonas aeruginosa ATCC 27853Not reported by sourceDBAASPS_13669_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0098Antimicrobial-125±0.0 µg/mlEnterococcus faecalis ATCC 29212Not reported by sourceDBAASPS_13669_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0099Antimicrobial-125±1.7 µg/mlCandida albicans ATCC 10231Not reported by sourceDBAASPS_13669_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0100Antimicrobial->1000 µg/mlCandida glabrata ATCC 90030Not reported by sourceDBAASPS_13669_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0101Antimicrobial-500±6.9 µg/mlCandida krusei ATCC 28870Not reported by sourceDBAASPS_13669_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0102Antimicrobial->1000 µg/mlCryptococcus neoformans ATCC 2517Not reported by sourceDBAASPS_13669_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0103Antimicrobial-254±3.4 µg/mlPenicillium pinophilum ATCC 9644Not reported by sourceDBAASPS_13669_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0104Antimicrobial->1000 µg/mlTrichophyton mentagrophytes ATCC 32510Not reported by sourceDBAASPS_13669_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0105Antimicrobial-125±0.0 µg/mlAspergillus fumigatus ATCC 1022Not reported by sourceDBAASPS_13669_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0106Antimicrobial->1000 µg/mlAspergillus niger ATCC 9142Not reported by sourceDBAASPS_13669_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0107Antimicrobial->1000 µg/mlAspergillus flavus ATCC 24109Not reported by sourceDBAASPS_13669_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0108Antimicrobial->1000 µg/mlMicrosporum canis PTCC 5069Not reported by sourceDBAASPS_13669_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0109Antimicrobial-125±0.0 µg/mlSaccharomyces cerevisiae PTCC 5052Not reported by sourceDBAASPS_13669_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0031Antimicrobial-100 µg/mlBacillus cereusNot reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0032Antimicrobial->100 µg/mlEscherichia coliNot reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0033Antimicrobial-12 µg/mlLeuconostoc lactisNot reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0034Antimicrobial-100 µg/mlListeria innocuaNot reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0035Antimicrobial-100 µg/mlMicrococcus luteusNot reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0036Antimicrobial-100 µg/mlPasteurella multocidaNot reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0037Antimicrobial-50 µg/mlStaphylococcus aureusNot reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0038Antimicrobial-50 µg/mlStaphylococcus epidermidisNot reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0039Antimicrobial-50 µg/mlStreptococcus uberisNot reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0040Antimicrobial-2.5-5.0 µMAcholeplasma laidlawii BNot reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0041Antimicrobial-10-100 µMHuman leukemiaNot reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0042Antimicrobial-10 µMHuman lung cancerNot reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0043Antimicrobial-10 µMHuman colon cancerNot reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0044Antimicrobial-10 µMHuman CNS cancerNot reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0045Antimicrobial-10 µMHuman melanomaNot reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0046Antimicrobial-10 µMHuman ovarian carcinomaNot reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0047Antimicrobial-10 µMHuman renal cancerNot reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0048Antimicrobial-10 µMHuman prostate cancerNot reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0049Antimicrobial-10 µMHuman breast cancerNot reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0050Antimicrobial-16 µMEscherichia coli ATCC 25922Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0051Antimicrobial-8 µMStaphylococcus aureus ATCC 25923Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0052Antimicrobial-32 µMCandida albicans ATCC 18804Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0053Antimicrobial-37.5 µMStaphylococcus aureus ATCC 29213Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0054Antimicrobial-125 µMStaphylococcus aureus ATCC 29213Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0055Antimicrobial-250 µMEscherichia coli MG1655Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0056Antimicrobial-250 µMEscherichia coli MG1655Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0057Antimicrobial-64 µg/mlEnterococcus faecalis PCM 2673Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0058Antimicrobial-128 µg/mlStaphylococcus aureus ATCC 25923Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0059Antimicrobial-128 µg/mlStaphylococcus aureus ATCC 9144Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0060Antimicrobial-64 µg/mlStreptococcus pneumoniae ATCC 49619Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0061Antimicrobial-128 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0062Antimicrobial-128 µg/mlEscherichia coli ATCC 23506Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0063Antimicrobial-16 µg/mlKlebsiella pneumoniae ATCC 700603Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0064Antimicrobial-256 µg/mlPseudomonas aeruginosa ATCC 9027Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0065Antimicrobial-64 µg/mlAspergillus niger ATCC 16404Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0066Antimicrobial-128 µg/mlCandida albicans ATCC 10231Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0067Antimicrobial-128 µg/mlCandida glabrata ATCC 15126Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0068Antimicrobial-16 µg/mlAcinetobacter baumannii ATCC 19606Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0069Antimicrobial-16 µg/mlAcinetobacter baumannii ATCC 19606Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0070Antimicrobial-25 µg/mlStaphylococcus aureus ATCC 29213Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0071Antimicrobial-25 µg/mlStaphylococcus aureus ATCC 29213Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0072Antimicrobial-50 µg/mlEnterococcus faecalis ATCC 29212Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0073Antimicrobial-50 µg/mlEnterococcus faecalis ATCC 29212Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0074Antimicrobial-200 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0075Antimicrobial-200 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0076Antimicrobial->200 µg/mlPseudomonas aeruginosa ATCC 27853Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0077Antimicrobial-50 µg/mlStaphylococcus aureus ATCC 29213Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0078Antimicrobial-100 µg/mlStaphylococcus aureus ATCC 29213Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0079Antimicrobial-100 µg/mlEnterococcus faecalis ATCC 29212Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0080Antimicrobial-200 µg/mlEnterococcus faecalis ATCC 29212Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0081Antimicrobial->200 µg/mlEscherichia coli ATCC 25922Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0082Antimicrobial->200 µg/mlPseudomonas aeruginosa ATCC 27853Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0083Antimicrobial-8 µg/mlStaphylococcus aureus ATCC 43300Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0084Antimicrobial-16 µg/mlEnterococcus faecalis ATCC 51299Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dbaasp_0085Antimicrobial-4 µg/mlStreptococcus pyogenes ATCC 19615Not reported by sourceDBAASPS_779_chain0dbaasp / linked
CTPDB_P035993_ACT_dramp_0110Antimicrobial-Not available in the current structured importUnknownNot reported by sourceDRAMP01607dramp / linked
CTPDB_P035993_ACT_dramp_0111AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourceDRAMP01607dramp / linked
CTPDB_P035993_ACT_dramp_0112AntimicrobialAnti-Gram+Not available in the current structured importUnknownNot reported by sourceDRAMP01607dramp / linked
CTPDB_P035993_ACT_dramp_0113AntimicrobialAnti-Gram-Not available in the current structured importUnknownNot reported by sourceDRAMP01607dramp / linked
CTPDB_P035993_ACT_dramp_0114Anticancer-Not available in the current structured importUnknownNot reported by sourceDRAMP01607dramp / linked
CTPDB_P035993_ACT_dramp_0115Antimicrobial-Not available in the current structured importUnknownNot reported by sourceDRAMP06343dramp / linked
CTPDB_P035993_ACT_hemolytik_0116ToxicityHemolytic128.0 µmErythrocytesNot reported by source2586hemolytik / linked
CTPDB_P035993_ACT_hemolytik_0117ToxicityHemolytic16.0 µmErythrocytesNot reported by source2587hemolytik / linked
CTPDB_P035993_ACT_satpdb_0118Anticancer-Not available in the current structured importUnknownNot reported by sourcesatpdb11488satpdb / linked
CTPDB_P035993_ACT_satpdb_0119AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourcesatpdb11488satpdb / linked
CTPDB_P035993_ACT_satpdb_0120Antiviral-Not available in the current structured importUnknownNot reported by sourcesatpdb11488satpdb / linked
CTPDB_P035993_ACT_satpdb_0121Antimicrobial-Not available in the current structured importUnknownNot reported by sourcesatpdb11488satpdb / linked
CTPDB_P035993_ACT_satpdb_0122AntimicrobialAntifungalNot available in the current structured importUnknownNot reported by sourcesatpdb11488satpdb / linked
CTPDB_P035993_ACT_satpdb_0123Anticancer-Not available in the current structured importUnknownNot reported by sourcesatpdb26109satpdb / linked
CTPDB_P035993_ACT_satpdb_0124AntimicrobialAntibacterialNot available in the current structured importUnknownNot reported by sourcesatpdb26109satpdb / linked
CTPDB_P035993_ACT_satpdb_0125ToxicityGeneral ToxicNot available in the current structured importUnknownNot reported by sourcesatpdb26109satpdb / linked
CTPDB_P035993_ACT_satpdb_0126Antimicrobial-Not available in the current structured importUnknownNot reported by sourcesatpdb26109satpdb / linked

Sequence-linked cross-layer evidence

Linked primary-literature evidence

29

Records

2

Papers

29

Positive

0

Negative

1

Primary identities

These observations were collected directly from primary literature and linked by identical normalized sequence. They remain a separate evidence layer and do not overwrite Integrated source-database annotations.

View PEPDIA-PLP-003592View all experimental records

Provenance

Source database records (24)

apd

AP00013

Raw sequence

GLFDIIKKIAESF

camp

CAMPSQ228

Raw sequence

GLFDIIKKIAESF

camp

CAMPSQ10450

Raw sequence

GLFDIIKKIAESF

camp

CAMPSQ11793

Raw sequence

GLFDIIKKIAESF

camp

CAMPSQ13624

Raw sequence

GLFDIIKKIAESF

cancerppd

1252

Raw sequence

GLFDIIKKIAESF

cancerppd

1253

Raw sequence

GLFDIIKKIAESF

cancerppd

1254

Raw sequence

GLFDIIKKIAESF

cancerppd

1255

Raw sequence

GLFDIIKKIAESF

cancerppd

1256

Raw sequence

GLFDIIKKIAESF

cancerppd

1257

Raw sequence

GLFDIIKKIAESF

cancerppd

1258

Raw sequence

GLFDIIKKIAESF

cancerppd

1259

Raw sequence

GLFDIIKKIAESF

cancerppd

1260

Raw sequence

GLFDIIKKIAESF

dbaasp

DBAASPS_779_chain0

Raw sequence

GLFDIIKKIAESF

dbaasp

DBAASPS_10333_chain0

Raw sequence

GLFDIIKKIAESF

dbaasp

DBAASPS_10334_chain0

Raw sequence

GLFDIIKKIAESF

dbaasp

DBAASPS_13669_chain0

Raw sequence

GLFDIIKKIAESF

dramp

DRAMP01607

Raw sequence

GLFDIIKKIAESF

dramp

DRAMP06343

Raw sequence

GLFDIIKKIAESF

hemolytik

2586

Raw sequence

GLFDIIKKIAESF

hemolytik

2587

Raw sequence

GLFDIIKKIAESF

satpdb

satpdb11488

Raw sequence

GLFDIIKKIAESF

satpdb

satpdb26109

Raw sequence

GLFDIIKKIAESF

Citation trail

Literature (14 records)

The antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.

Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.2000, Australia

Eur J Biochem2000PMID 10951191

The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.

Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ

Eur J Biochem2000PMID 17825246

The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.

Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ

Eur J Biochem2000PMID 23519707

The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.

Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ

Eur J Biochem2000PMID 28756544

The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.

Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ

Eur J Biochem2000PMID 33271197

The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.

Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ

Eur J Biochem2000PMID 17220421

The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.##Correlation of three-dimensional structures with the antibacterial activity of a group of peptides designed based on a nontoxic bacterial membrane anchor.##Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.

Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC, Tyler MJ.##Wang G, Li Y, Li X.##Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.

Eur J Biochem2000PMID 15203252

IP evidence

Patents (1)

US 20080125359

dramp

Audit surface

Raw annotations and release metadata

Integrated record last updated: 2026-04-15T00:59:11.802554+00:00

Modification summary

No structured modification annotations are available for this record.

ADMET
{
  "toxicity": [
    {
      "unit": "µM",
      "value": "128",
      "source_db": "dbaasp",
      "assay_method": "50% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "50",
      "source_db": "dbaasp",
      "assay_method": "5% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "200",
      "source_db": "dbaasp",
      "assay_method": "39.96% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µg/ml",
      "value": "200",
      "source_db": "dbaasp",
      "assay_method": "LC50",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human dermal fibroblasts"
    },
    {
      "unit": "µg/ml",
      "value": "1000",
      "source_db": "dbaasp",
      "assay_method": "62% Cytotoxicity",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human skin fibroblasts"
    },
    {
      "unit": "µg/ml",
      "value": ">700.145",
      "source_db": "dbaasp",
      "assay_method": "IC50",
      "toxicity_type": "Cytotoxic",
      "target_cellline": "Human skin fibroblasts"
    },
    {
      "unit": "µg/ml",
      "value": "1000",
      "source_db": "dbaasp",
      "assay_method": "19.38% Hemolysis",
      "toxicity_type": "Hemolytic",
      "target_cellline": "Human erythrocytes"
    },
    {
      "unit": "µM",
      "source_db": "dramp",
      "assay_method": "[Ref.10951191]No cytotoxicity information found##[Ref.15572363]No cytotoxicity information found",
      "toxicity_type": "Cytotoxic"
    }
  ]
}
Source metadata
[
  {
    "source_db": "apd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "camp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "cancerppd",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dbaasp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "dramp",
    "organism_name": "Unknown"
  },
  {
    "source_db": "hemolytik",
    "organism_name": "Unknown"
  },
  {
    "source_db": "satpdb",
    "organism_name": "Unknown"
  }
]
Structure metadata
{
  "pdb_id": "1VM5 resolved by NMR.",
  "source_db": "dramp"
}