Bioinformatics and Biology Insights · 2025
Sequence evidence
LQYPDDSDDE
the anionic peptide derived from nectin-1... Peptide C1 (10-mer peptide: residues 416-425, LQYPDDSDDE)
Experimental observations
Cell viability of 91.74% ... at 250 µg/mL peptide concentration, respectively ( Figure S5 ) for C1. Both peptides were nontoxic to Vero cells at all the concentrations of 15.62 - 250 µg/mL.
In the viral inactivation assay, peptide C1 at 250 µg/mL reduced HSV-1 ... infections by 64.92% ... with IC 50 values of 109.9 ... µg/mL
In the viral inactivation assay, peptide C1 at 250 µg/mL reduced ... HSV-2 infections by ... 67.16%, respectively, with IC 50 values of ... 111.13 µg/mL
In the viral inactivation assay, peptide C1 at 250 µg/mL reduced HSV-1 ... infections by 64.92%
In the viral inactivation assay, peptide C1 at 250 µg/mL reduced ... HSV-2 infections by 67.16%
The IC 50 values of peptide C1 against HSV-1 and HSV-2 were 182.93 and 164.6 µg/mL, respectively
The IC 50 values of peptide C1 against HSV-1 and HSV-2 were 182.93 and 164.6 µg/mL, respectively
Peptide C1 offered 62.03% protection against HSV-1 and 59.38% protection against HSV-2 infections at 250 µg/mL in the viral attachment inhibition assay.
Peptide C1 offered 62.03% protection against HSV-1 and 59.38% protection against HSV-2 infections at 250 µg/mL in the viral attachment inhibition assay.
The IC 50 values were found to be 125.86 and 97.76 µg/mL for HSV-1 and HSV-2 infections, respectively
The IC 50 values were found to be 125.86 and 97.76 µg/mL for HSV-1 and HSV-2 infections, respectively
Moreover, peptide C1 showed better protection (HSV-1: 71.37%, HSV-2: 76.28%) in viral entry inhibition assay at 250 µg/mL concentration.
Moreover, peptide C1 showed better protection (HSV-1: 71.37%, HSV-2: 76.28%) in viral entry inhibition assay at 250 µg/mL concentration.
at the highest concentration (250 µg/mL), peptide C1 demonstrated 49.37% ... protection against HSV-1 ... in the CPE inhibition assay
at the highest concentration (250 µg/mL), peptide C1 demonstrated ... 48.99% protection against ... HSV-2 in the CPE inhibition assay
Neither C1 nor C2 peptide offered protection to Vero cells in the cell-pretreatment assay.
Neither C1 nor C2 peptide offered protection to Vero cells in the cell-pretreatment assay.
Local peptide labels such as P1, PEP1, or peptide 1 are grouped only within this paper and are not assumed to represent the same molecule across publications.
